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STRINGSTRING
PDIA2 PDIA2 MUC4 MUC4 ZMPSTE24 ZMPSTE24 CCDC85C CCDC85C ISM2 ISM2 SUSD2 SUSD2 NOXRED1 NOXRED1 C14orf178 C14orf178 SAMD15 SAMD15 TUBGCP3 TUBGCP3 TAAR1 TAAR1
"ISM2" - Isthmin-2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ISM2Isthmin-2; Isthmin 2 (571 aa)    
Predicted Functional Partners:
MUC4
Mucin-4; May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 ’Tyr-1248’. In [...] (5412 aa)
            
  0.803
SUSD2
Sushi domain-containing protein 2; May be a cytokine receptor for C10ORF99. May be a tumor suppressor; together with C10ORF99 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest. May play a role in breast tumorigenesis; Sushi domain containing (822 aa)
            
  0.771
NOXRED1
NADP-dependent oxidoreductase domain-containing protein 1; Probable oxidoreductase (359 aa)
            
  0.574
PDIA2
Protein disulfide-isomerase A2; Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins; Protein disulfide isomerases (525 aa)
      
   
  0.540
TUBGCP3
Gamma-tubulin complex component 3; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome (907 aa)
            
  0.530
C14orf178
Uncharacterized protein C14orf178; Chromosome 14 open reading frame 178 (122 aa)
            
  0.530
CCDC85C
Coiled-coil domain-containing protein 85C; May play an important role in cortical development, especially in the maintenance of radial glia (419 aa)
            
  0.503
ZMPSTE24
CAAX prenyl protease 1 homolog; Proteolytically removes the C-terminal three residues of farnesylated proteins. Acts on lamin A/C (475 aa)
            
  0.492
TAAR1
Trace amine-associated receptor 1; Receptor for trace amines, including beta- phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonin. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained sp [...] (339 aa)
            
  0.490
SAMD15
Sterile alpha motif domain containing 15 (674 aa)
            
  0.474
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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