node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADRM1 | C20orf24 | ENSP00000478877 | ENSP00000341213 | Proteasomal ubiquitin receptor ADRM1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engag [...] | Uncharacterized protein C20orf24; Chromosome 20 open reading frame 24 | 0.495 |
ADRM1 | MRGBP | ENSP00000478877 | ENSP00000359518 | Proteasomal ubiquitin receptor ADRM1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engag [...] | MRG/MORF4L-binding protein; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative [...] | 0.406 |
C20orf24 | ADRM1 | ENSP00000341213 | ENSP00000478877 | Uncharacterized protein C20orf24; Chromosome 20 open reading frame 24 | Proteasomal ubiquitin receptor ADRM1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engag [...] | 0.495 |
C20orf24 | GART | ENSP00000341213 | ENSP00000371253 | Uncharacterized protein C20orf24; Chromosome 20 open reading frame 24 | Trifunctional purine biosynthetic protein adenosine-3; Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; In the central section; belongs to the AIR synthase family | 0.480 |
C20orf24 | GID8 | ENSP00000341213 | ENSP00000266069 | Uncharacterized protein C20orf24; Chromosome 20 open reading frame 24 | Glucose-induced degradation protein 8 homolog; GID complex subunit 8 homolog | 0.545 |
C20orf24 | KHNYN | ENSP00000341213 | ENSP00000251343 | Uncharacterized protein C20orf24; Chromosome 20 open reading frame 24 | Protein KHNYN; KH and NYN domain containing; Belongs to the N4BP1 family | 0.472 |
C20orf24 | MRGBP | ENSP00000341213 | ENSP00000359518 | Uncharacterized protein C20orf24; Chromosome 20 open reading frame 24 | MRG/MORF4L-binding protein; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative [...] | 0.633 |
C20orf24 | NOC4L | ENSP00000341213 | ENSP00000328854 | Uncharacterized protein C20orf24; Chromosome 20 open reading frame 24 | Nucleolar complex protein 4 homolog; Armadillo-like helical domain containing; Belongs to the CBF/MAK21 family | 0.580 |
C20orf24 | RBM38 | ENSP00000341213 | ENSP00000348538 | Uncharacterized protein C20orf24; Chromosome 20 open reading frame 24 | RNA-binding protein 38; RNA-binding protein that specifically bind the 3’-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2- I [...] | 0.508 |
C20orf24 | RRP9 | ENSP00000341213 | ENSP00000232888 | Uncharacterized protein C20orf24; Chromosome 20 open reading frame 24 | U3 small nucleolar RNA-interacting protein 2; Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA; Belongs to the WD repeat RRP9 family | 0.472 |
C20orf24 | SRPRB | ENSP00000341213 | ENSP00000418401 | Uncharacterized protein C20orf24; Chromosome 20 open reading frame 24 | Signal recognition particle receptor subunit beta; Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity) | 0.557 |
C20orf24 | ZNF707 | ENSP00000341213 | ENSP00000436212 | Uncharacterized protein C20orf24; Chromosome 20 open reading frame 24 | Zinc finger protein 707; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.473 |
GART | C20orf24 | ENSP00000371253 | ENSP00000341213 | Trifunctional purine biosynthetic protein adenosine-3; Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; In the central section; belongs to the AIR synthase family | Uncharacterized protein C20orf24; Chromosome 20 open reading frame 24 | 0.480 |
GART | NOC4L | ENSP00000371253 | ENSP00000328854 | Trifunctional purine biosynthetic protein adenosine-3; Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; In the central section; belongs to the AIR synthase family | Nucleolar complex protein 4 homolog; Armadillo-like helical domain containing; Belongs to the CBF/MAK21 family | 0.600 |
GART | RRP9 | ENSP00000371253 | ENSP00000232888 | Trifunctional purine biosynthetic protein adenosine-3; Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; In the central section; belongs to the AIR synthase family | U3 small nucleolar RNA-interacting protein 2; Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA; Belongs to the WD repeat RRP9 family | 0.595 |
GART | SRPRB | ENSP00000371253 | ENSP00000418401 | Trifunctional purine biosynthetic protein adenosine-3; Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; In the central section; belongs to the AIR synthase family | Signal recognition particle receptor subunit beta; Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity) | 0.477 |
GID8 | C20orf24 | ENSP00000266069 | ENSP00000341213 | Glucose-induced degradation protein 8 homolog; GID complex subunit 8 homolog | Uncharacterized protein C20orf24; Chromosome 20 open reading frame 24 | 0.545 |
GID8 | MRGBP | ENSP00000266069 | ENSP00000359518 | Glucose-induced degradation protein 8 homolog; GID complex subunit 8 homolog | MRG/MORF4L-binding protein; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative [...] | 0.615 |
GID8 | RBM38 | ENSP00000266069 | ENSP00000348538 | Glucose-induced degradation protein 8 homolog; GID complex subunit 8 homolog | RNA-binding protein 38; RNA-binding protein that specifically bind the 3’-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2- I [...] | 0.450 |
KHNYN | C20orf24 | ENSP00000251343 | ENSP00000341213 | Protein KHNYN; KH and NYN domain containing; Belongs to the N4BP1 family | Uncharacterized protein C20orf24; Chromosome 20 open reading frame 24 | 0.472 |