| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C3orf62 | CCDC36 | ENSP00000341139 | ENSP00000391788 | Uncharacterized protein C3orf62; Chromosome 3 open reading frame 62 | Interactor of HORMAD1 protein 1; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance | 0.624 |
| C3orf62 | EP300 | ENSP00000341139 | ENSP00000263253 | Uncharacterized protein C3orf62; Chromosome 3 open reading frame 62 | Histone acetyltransferase p300; Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at ’Lys-122’ (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at ’Lys-27’ (H3K [...] | 0.534 |
| C3orf62 | GLIPR1L2 | ENSP00000341139 | ENSP00000448248 | Uncharacterized protein C3orf62; Chromosome 3 open reading frame 62 | GLIPR1-like protein 2; GLI pathogenesis related family 1; Belongs to the CRISP family | 0.515 |
| C3orf62 | MYO18B | ENSP00000341139 | ENSP00000334563 | Uncharacterized protein C3orf62; Chromosome 3 open reading frame 62 | Unconventional myosin-XVIIIb; May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family | 0.529 |
| C3orf62 | SEZ6L | ENSP00000341139 | ENSP00000248933 | Uncharacterized protein C3orf62; Chromosome 3 open reading frame 62 | Seizure 6-like protein; May contribute to specialized endoplasmic reticulum functions in neurons; Sushi domain containing | 0.626 |
| C3orf62 | USP4 | ENSP00000341139 | ENSP00000265560 | Uncharacterized protein C3orf62; Chromosome 3 open reading frame 62 | Ubiquitin carboxyl-terminal hydrolase 4; Hydrolase that deubiquitinates target proteins such as the receptor ADORA2A, PDPK1 and TRIM21. Deubiquitination of ADORA2A increases the amount of functional receptor at the cell surface. May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3. This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP. May also play a role in the regulation of quality control in the ER; Ubiquitin specific peptidases | 0.441 |
| CCDC36 | C3orf62 | ENSP00000391788 | ENSP00000341139 | Interactor of HORMAD1 protein 1; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance | Uncharacterized protein C3orf62; Chromosome 3 open reading frame 62 | 0.624 |
| CCDC36 | MYO18B | ENSP00000391788 | ENSP00000334563 | Interactor of HORMAD1 protein 1; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance | Unconventional myosin-XVIIIb; May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family | 0.677 |
| CCDC36 | SEZ6L | ENSP00000391788 | ENSP00000248933 | Interactor of HORMAD1 protein 1; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance | Seizure 6-like protein; May contribute to specialized endoplasmic reticulum functions in neurons; Sushi domain containing | 0.682 |
| EP300 | C3orf62 | ENSP00000263253 | ENSP00000341139 | Histone acetyltransferase p300; Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at ’Lys-122’ (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at ’Lys-27’ (H3K [...] | Uncharacterized protein C3orf62; Chromosome 3 open reading frame 62 | 0.534 |
| GLIPR1L2 | C3orf62 | ENSP00000448248 | ENSP00000341139 | GLIPR1-like protein 2; GLI pathogenesis related family 1; Belongs to the CRISP family | Uncharacterized protein C3orf62; Chromosome 3 open reading frame 62 | 0.515 |
| MYO18B | C3orf62 | ENSP00000334563 | ENSP00000341139 | Unconventional myosin-XVIIIb; May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family | Uncharacterized protein C3orf62; Chromosome 3 open reading frame 62 | 0.529 |
| MYO18B | CCDC36 | ENSP00000334563 | ENSP00000391788 | Unconventional myosin-XVIIIb; May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family | Interactor of HORMAD1 protein 1; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance | 0.677 |
| MYO18B | SEZ6L | ENSP00000334563 | ENSP00000248933 | Unconventional myosin-XVIIIb; May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family | Seizure 6-like protein; May contribute to specialized endoplasmic reticulum functions in neurons; Sushi domain containing | 0.905 |
| SEZ6L | C3orf62 | ENSP00000248933 | ENSP00000341139 | Seizure 6-like protein; May contribute to specialized endoplasmic reticulum functions in neurons; Sushi domain containing | Uncharacterized protein C3orf62; Chromosome 3 open reading frame 62 | 0.626 |
| SEZ6L | CCDC36 | ENSP00000248933 | ENSP00000391788 | Seizure 6-like protein; May contribute to specialized endoplasmic reticulum functions in neurons; Sushi domain containing | Interactor of HORMAD1 protein 1; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance | 0.682 |
| SEZ6L | MYO18B | ENSP00000248933 | ENSP00000334563 | Seizure 6-like protein; May contribute to specialized endoplasmic reticulum functions in neurons; Sushi domain containing | Unconventional myosin-XVIIIb; May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family | 0.905 |
| USP4 | C3orf62 | ENSP00000265560 | ENSP00000341139 | Ubiquitin carboxyl-terminal hydrolase 4; Hydrolase that deubiquitinates target proteins such as the receptor ADORA2A, PDPK1 and TRIM21. Deubiquitination of ADORA2A increases the amount of functional receptor at the cell surface. May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3. This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP. May also play a role in the regulation of quality control in the ER; Ubiquitin specific peptidases | Uncharacterized protein C3orf62; Chromosome 3 open reading frame 62 | 0.441 |
