node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CSN1S1 | CSN2 | ENSP00000246891 | ENSP00000341030 | Alpha-S1-casein; Important role in the capacity of milk to transport calcium phosphate; Belongs to the alpha-casein family | Beta-casein; Important role in determination of the surface properties of the casein micelles; Belongs to the beta-casein family | 0.910 |
CSN1S1 | CSN3 | ENSP00000246891 | ENSP00000304822 | Alpha-S1-casein; Important role in the capacity of milk to transport calcium phosphate; Belongs to the alpha-casein family | Kappa-casein; Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk; Belongs to the kappa-casein family | 0.860 |
CSN1S1 | CSNK2B | ENSP00000246891 | ENSP00000365042 | Alpha-S1-casein; Important role in the capacity of milk to transport calcium phosphate; Belongs to the alpha-casein family | Casein kinase II subunit beta; Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family | 0.493 |
CSN1S1 | LALBA | ENSP00000246891 | ENSP00000301046 | Alpha-S1-casein; Important role in the capacity of milk to transport calcium phosphate; Belongs to the alpha-casein family | Alpha-lactalbumin; Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins; Belongs to the glycosyl hydrolase 22 family | 0.846 |
CSN1S1 | PRL | ENSP00000246891 | ENSP00000302150 | Alpha-S1-casein; Important role in the capacity of milk to transport calcium phosphate; Belongs to the alpha-casein family | Prolactin; Prolactin acts primarily on the mammary gland by promoting lactation; Growth hormone family | 0.718 |
CSN2 | CSN1S1 | ENSP00000341030 | ENSP00000246891 | Beta-casein; Important role in determination of the surface properties of the casein micelles; Belongs to the beta-casein family | Alpha-S1-casein; Important role in the capacity of milk to transport calcium phosphate; Belongs to the alpha-casein family | 0.910 |
CSN2 | CSN3 | ENSP00000341030 | ENSP00000304822 | Beta-casein; Important role in determination of the surface properties of the casein micelles; Belongs to the beta-casein family | Kappa-casein; Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk; Belongs to the kappa-casein family | 0.929 |
CSN2 | CSNK2B | ENSP00000341030 | ENSP00000365042 | Beta-casein; Important role in determination of the surface properties of the casein micelles; Belongs to the beta-casein family | Casein kinase II subunit beta; Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family | 0.685 |
CSN2 | HTRA2 | ENSP00000341030 | ENSP00000258080 | Beta-casein; Important role in determination of the surface properties of the casein micelles; Belongs to the beta-casein family | Serine protease HTRA2, mitochondrial; Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive; Belongs to the peptidase S1C family | 0.655 |
CSN2 | LALBA | ENSP00000341030 | ENSP00000301046 | Beta-casein; Important role in determination of the surface properties of the casein micelles; Belongs to the beta-casein family | Alpha-lactalbumin; Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins; Belongs to the glycosyl hydrolase 22 family | 0.907 |
CSN2 | NEK9 | ENSP00000341030 | ENSP00000238616 | Beta-casein; Important role in determination of the surface properties of the casein micelles; Belongs to the beta-casein family | Serine/threonine-protein kinase Nek9; Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively; Belongs to the protein kinase superfamily. NEK Ser/Thr protein k [...] | 0.721 |
CSN2 | PRL | ENSP00000341030 | ENSP00000302150 | Beta-casein; Important role in determination of the surface properties of the casein micelles; Belongs to the beta-casein family | Prolactin; Prolactin acts primarily on the mammary gland by promoting lactation; Growth hormone family | 0.894 |
CSN2 | PRLR | ENSP00000341030 | ENSP00000482954 | Beta-casein; Important role in determination of the surface properties of the casein micelles; Belongs to the beta-casein family | Prolactin receptor; This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling | 0.675 |
CSN2 | STAT5A | ENSP00000341030 | ENSP00000341208 | Beta-casein; Important role in determination of the surface properties of the casein micelles; Belongs to the beta-casein family | Signal transducer and activator of transcription 5A; Carries out a dual function- signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation; SH2 domain containing | 0.978 |
CSN2 | STAT5B | ENSP00000341030 | ENSP00000293328 | Beta-casein; Important role in determination of the surface properties of the casein micelles; Belongs to the beta-casein family | Signal transducer and activator of transcription 5B; Carries out a dual function- signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation | 0.793 |
CSN3 | CSN1S1 | ENSP00000304822 | ENSP00000246891 | Kappa-casein; Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk; Belongs to the kappa-casein family | Alpha-S1-casein; Important role in the capacity of milk to transport calcium phosphate; Belongs to the alpha-casein family | 0.860 |
CSN3 | CSN2 | ENSP00000304822 | ENSP00000341030 | Kappa-casein; Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk; Belongs to the kappa-casein family | Beta-casein; Important role in determination of the surface properties of the casein micelles; Belongs to the beta-casein family | 0.929 |
CSN3 | LALBA | ENSP00000304822 | ENSP00000301046 | Kappa-casein; Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk; Belongs to the kappa-casein family | Alpha-lactalbumin; Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins; Belongs to the glycosyl hydrolase 22 family | 0.862 |
CSNK2B | CSN1S1 | ENSP00000365042 | ENSP00000246891 | Casein kinase II subunit beta; Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family | Alpha-S1-casein; Important role in the capacity of milk to transport calcium phosphate; Belongs to the alpha-casein family | 0.493 |
CSNK2B | CSN2 | ENSP00000365042 | ENSP00000341030 | Casein kinase II subunit beta; Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family | Beta-casein; Important role in determination of the surface properties of the casein micelles; Belongs to the beta-casein family | 0.685 |