node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACSM3 | SPAG8 | ENSP00000289416 | ENSP00000340982 | Acyl-coenzyme A synthetase ACSM3, mitochondrial; Has medium-chain fatty acid-CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity); Acyl-CoA synthetase family | Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5-regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis. May play a role in fertility and microtubule formation through interaction with RANBP9 [...] | 0.634 |
CCNDBP1 | CT45A4 | ENSP00000300213 | ENSP00000481184 | Cyclin-D1-binding protein 1; May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F- dependent transcription | Cancer/testis antigen family 45 member A3 | 0.400 |
CCNDBP1 | ENSG00000278289 | ENSP00000300213 | ENSP00000479608 | Cyclin-D1-binding protein 1; May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F- dependent transcription | Cancer/testis antigen family 45 member A6 | 0.441 |
CCNDBP1 | FBXO39 | ENSP00000300213 | ENSP00000321386 | Cyclin-D1-binding protein 1; May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F- dependent transcription | F-box only protein 39; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other | 0.518 |
CCNDBP1 | SPAG8 | ENSP00000300213 | ENSP00000340982 | Cyclin-D1-binding protein 1; May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F- dependent transcription | Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5-regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis. May play a role in fertility and microtubule formation through interaction with RANBP9 [...] | 0.566 |
CRISPLD1 | SPAG8 | ENSP00000262207 | ENSP00000340982 | Cysteine rich secretory protein LCCL domain containing 1; Belongs to the CRISP family | Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5-regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis. May play a role in fertility and microtubule formation through interaction with RANBP9 [...] | 0.540 |
CT45A4 | CCNDBP1 | ENSP00000481184 | ENSP00000300213 | Cancer/testis antigen family 45 member A3 | Cyclin-D1-binding protein 1; May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F- dependent transcription | 0.400 |
CT45A4 | FBXO39 | ENSP00000481184 | ENSP00000321386 | Cancer/testis antigen family 45 member A3 | F-box only protein 39; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other | 0.567 |
CT45A4 | PRSS55 | ENSP00000481184 | ENSP00000333003 | Cancer/testis antigen family 45 member A3 | Serine protease 55; Probable serine protease | 0.474 |
CT45A4 | SPAG8 | ENSP00000481184 | ENSP00000340982 | Cancer/testis antigen family 45 member A3 | Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5-regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis. May play a role in fertility and microtubule formation through interaction with RANBP9 [...] | 0.550 |
ENSG00000278289 | CCNDBP1 | ENSP00000479608 | ENSP00000300213 | Cancer/testis antigen family 45 member A6 | Cyclin-D1-binding protein 1; May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F- dependent transcription | 0.441 |
ENSG00000278289 | FBXO39 | ENSP00000479608 | ENSP00000321386 | Cancer/testis antigen family 45 member A6 | F-box only protein 39; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other | 0.595 |
ENSG00000278289 | PRSS55 | ENSP00000479608 | ENSP00000333003 | Cancer/testis antigen family 45 member A6 | Serine protease 55; Probable serine protease | 0.527 |
ENSG00000278289 | SPAG8 | ENSP00000479608 | ENSP00000340982 | Cancer/testis antigen family 45 member A6 | Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5-regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis. May play a role in fertility and microtubule formation through interaction with RANBP9 [...] | 0.579 |
FBXO39 | CCNDBP1 | ENSP00000321386 | ENSP00000300213 | F-box only protein 39; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other | Cyclin-D1-binding protein 1; May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F- dependent transcription | 0.518 |
FBXO39 | CT45A4 | ENSP00000321386 | ENSP00000481184 | F-box only protein 39; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other | Cancer/testis antigen family 45 member A3 | 0.567 |
FBXO39 | ENSG00000278289 | ENSP00000321386 | ENSP00000479608 | F-box only protein 39; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other | Cancer/testis antigen family 45 member A6 | 0.595 |
FBXO39 | GOLGA6L2 | ENSP00000321386 | ENSP00000454407 | F-box only protein 39; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other | Golgin subfamily A member 6-like protein 2; Golgin A6 family-like 2; Belongs to the GOLGA6 family | 0.644 |
FBXO39 | PRSS55 | ENSP00000321386 | ENSP00000333003 | F-box only protein 39; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other | Serine protease 55; Probable serine protease | 0.743 |
FBXO39 | SPAG17 | ENSP00000321386 | ENSP00000337804 | F-box only protein 39; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other | Sperm-associated antigen 17; Component of the central pair apparatus of ciliary axonemes. Plays a critical role in the function and structure of motile cilia. May play a role in endochondral bone formation, most likely because of a function in primary cilia of chondrocytes and osteoblasts | 0.754 |