| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARMC8 | ZNF621 | ENSP00000420333 | ENSP00000340841 | Armadillo repeat containing 8 | Zinc finger protein 621; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.440 |
| CBX5 | TRIM28 | ENSP00000209875 | ENSP00000253024 | Chromobox protein homolog 5; Component of heterochromatin that recognizes and binds histone H3 tails methylated at ’Lys-9’ (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when ’Tyr-41’ of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins; Chromobox family | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.728 |
| CBX5 | ZNF621 | ENSP00000209875 | ENSP00000340841 | Chromobox protein homolog 5; Component of heterochromatin that recognizes and binds histone H3 tails methylated at ’Lys-9’ (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when ’Tyr-41’ of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins; Chromobox family | Zinc finger protein 621; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.566 |
| NASP | ZNF621 | ENSP00000255120 | ENSP00000340841 | Nuclear autoantigenic sperm protein; Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA | Zinc finger protein 621; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.443 |
| OR4Q3 | ZNF621 | ENSP00000330049 | ENSP00000340841 | Olfactory receptor 4Q3; Odorant receptor; Olfactory receptors, family 4 | Zinc finger protein 621; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.440 |
| RNASE2 | ZNF621 | ENSP00000303276 | ENSP00000340841 | Non-secretory ribonuclease; This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities | Zinc finger protein 621; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.411 |
| SPEF2 | ZNF621 | ENSP00000348314 | ENSP00000340841 | Sperm flagellar protein 2; Required for correct axoneme development | Zinc finger protein 621; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.418 |
| SRBD1 | ZNF621 | ENSP00000263736 | ENSP00000340841 | S1 RNA-binding domain-containing protein 1; S1 RNA binding domain 1 | Zinc finger protein 621; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.477 |
| TARBP1 | TRUB1 | ENSP00000040877 | ENSP00000298746 | Probable methyltransferase TARBP1; Probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as tRNAs. In case of infection by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA polymerase II. Binding of TARBP1 and RNA polymerase II to HIV-1 TAR RNA is mutually exclusive, suggesting that TARBP1 may function alone or in conjunction with HIV-1 Tat to disengage RNA polymerase II from HIV-1 TAR RNA. May act by methylating HIV-1 TAR RNA; Armadillo-like helical domain containing | Probable tRNA pseudouridine synthase 1; May be responsible for synthesis of pseudouridine from uracil in transfer RNAs | 0.799 |
| TARBP1 | ZNF621 | ENSP00000040877 | ENSP00000340841 | Probable methyltransferase TARBP1; Probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as tRNAs. In case of infection by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA polymerase II. Binding of TARBP1 and RNA polymerase II to HIV-1 TAR RNA is mutually exclusive, suggesting that TARBP1 may function alone or in conjunction with HIV-1 Tat to disengage RNA polymerase II from HIV-1 TAR RNA. May act by methylating HIV-1 TAR RNA; Armadillo-like helical domain containing | Zinc finger protein 621; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.545 |
| TRIM28 | CBX5 | ENSP00000253024 | ENSP00000209875 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Chromobox protein homolog 5; Component of heterochromatin that recognizes and binds histone H3 tails methylated at ’Lys-9’ (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when ’Tyr-41’ of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins; Chromobox family | 0.728 |
| TRIM28 | ZNF621 | ENSP00000253024 | ENSP00000340841 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 621; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.923 |
| TRUB1 | TARBP1 | ENSP00000298746 | ENSP00000040877 | Probable tRNA pseudouridine synthase 1; May be responsible for synthesis of pseudouridine from uracil in transfer RNAs | Probable methyltransferase TARBP1; Probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as tRNAs. In case of infection by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA polymerase II. Binding of TARBP1 and RNA polymerase II to HIV-1 TAR RNA is mutually exclusive, suggesting that TARBP1 may function alone or in conjunction with HIV-1 Tat to disengage RNA polymerase II from HIV-1 TAR RNA. May act by methylating HIV-1 TAR RNA; Armadillo-like helical domain containing | 0.799 |
| TRUB1 | ZNF621 | ENSP00000298746 | ENSP00000340841 | Probable tRNA pseudouridine synthase 1; May be responsible for synthesis of pseudouridine from uracil in transfer RNAs | Zinc finger protein 621; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.571 |
| ZNF621 | ARMC8 | ENSP00000340841 | ENSP00000420333 | Zinc finger protein 621; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Armadillo repeat containing 8 | 0.440 |
| ZNF621 | CBX5 | ENSP00000340841 | ENSP00000209875 | Zinc finger protein 621; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Chromobox protein homolog 5; Component of heterochromatin that recognizes and binds histone H3 tails methylated at ’Lys-9’ (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when ’Tyr-41’ of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins; Chromobox family | 0.566 |
| ZNF621 | NASP | ENSP00000340841 | ENSP00000255120 | Zinc finger protein 621; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Nuclear autoantigenic sperm protein; Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA | 0.443 |
| ZNF621 | OR4Q3 | ENSP00000340841 | ENSP00000330049 | Zinc finger protein 621; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Olfactory receptor 4Q3; Odorant receptor; Olfactory receptors, family 4 | 0.440 |
| ZNF621 | RNASE2 | ENSP00000340841 | ENSP00000303276 | Zinc finger protein 621; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Non-secretory ribonuclease; This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities | 0.411 |
| ZNF621 | SPEF2 | ENSP00000340841 | ENSP00000348314 | Zinc finger protein 621; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Sperm flagellar protein 2; Required for correct axoneme development | 0.418 |
