• Version:
  • 11.0 [archived version]
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SPTAN1 SPTAN1 SPRYD4 SPRYD4 IMMP2L IMMP2L LRRC19 LRRC19 ZCCHC10 ZCCHC10 ARMCX3 ARMCX3 TRAK2 TRAK2 TRMT11 TRMT11 TMEM214 TMEM214 RANBP6 RANBP6 RB1 RB1
"ARMCX3" - Armadillo repeat-containing X-linked protein 3 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ARMCX3Armadillo repeat-containing X-linked protein 3; Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2- kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters; Armadillo repeat containing (379 aa)    
Predicted Functional Partners:
TMEM214
Transmembrane protein 214; Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress; Belongs to the TMEM214 family (689 aa)
           
  0.746
LRRC19
Leucine-rich repeat-containing protein 19; Leucine rich repeat containing 19 (370 aa)
           
  0.738
TRMT11
tRNA (guanine(10)-N2)-methyltransferase homolog; Catalytic subunit of an S-adenosyl-L-methionine- dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs (463 aa)
           
  0.721
IMMP2L
Mitochondrial inner membrane protease subunit 2; Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO; Belongs to the peptidase S26 family. IMP2 subfamily (175 aa)
           
  0.682
SPTAN1
Spectrin alpha chain, non-erythrocytic 1; Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane; EF-hand domain containing (2477 aa)
           
  0.641
ZCCHC10
Zinc finger CCHC-type containing 10 (192 aa)
           
  0.611
RANBP6
Ran-binding protein 6; May function in nuclear protein import as nuclear transport receptor; Armadillo-like helical domain containing (1105 aa)
       
      0.588
TRAK2
Trafficking kinesin-binding protein 2; May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR (914 aa)
     
   
  0.572
SPRYD4
SPRY domain containing 4 (207 aa)
           
  0.548
RB1
Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransfer [...] (928 aa)
           
  0.535
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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