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STRINGSTRING
MCHR2 MCHR2 AGTR1 AGTR1 NMS NMS ADRA1D ADRA1D NPS NPS QRFP QRFP F2RL3 F2RL3 UTS2 UTS2 UTS2B UTS2B UTS2R UTS2R PROK2 PROK2
"UTS2B" - Urotensin-2B in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
UTS2BUrotensin-2B; Potent vasoconstrictor; Endogenous ligands (119 aa)    
Predicted Functional Partners:
UTS2R
Urotensin-2 receptor; High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system (389 aa)
        
  0.987
UTS2
Urotensin 2; Endogenous ligands (139 aa)
      
 
  0.982
QRFP
Orexigenic neuropeptide QRFP; Stimulates feeding behavior, metabolic rate and locomotor activity and increases blood pressure. May have orexigenic activity. May promote aldosterone secretion by the adrenal gland (By similarity); Belongs to the RFamide neuropeptide family (136 aa)
          
  0.944
PROK2
Prokineticin-2; May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle; Endogenous ligands (129 aa)
          
  0.929
NMS
Neuromedin-S; Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions; Endogenous ligands (153 aa)
          
  0.921
F2RL3
Proteinase-activated receptor 4; Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation; Belongs to the G-protein coupled receptor 1 family (385 aa)
          
  0.921
NPS
Neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations; Endogenous ligands (89 aa)
          
  0.918
ADRA1D
Alpha-1D adrenergic receptor; This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium; Adrenoceptors (572 aa)
          
  0.913
MCHR2
Melanin-concentrating hormone receptor 2; Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis (340 aa)
          
  0.913
AGTR1
Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system (359 aa)
          
  0.911
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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