| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADAM2 | CLGN | ENSP00000265708 | ENSP00000326699 | Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein; ADAM metallopeptidase domain containing | Calmegin; Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions (By similarity) | 0.939 |
| ADAM2 | SERINC3 | ENSP00000265708 | ENSP00000340243 | Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein; ADAM metallopeptidase domain containing | Serine incorporator 3; Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1- acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm; Belongs to the TDE1 family | 0.527 |
| BST2 | SAMHD1 | ENSP00000252593 | ENSP00000262878 | Bone marrow stromal antigen 2; IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae- h [...] | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1; Host restriction nuclease involved in defense response to virus. Has dNTPase activity and reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur. Blocks early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. May play a role in mediating proinflammatory responses to TNF-alpha signaling. Has ribonuclease activity, acting on single-stranded RNA. This activity is essential for H1V-1 restriction; Sterile alpha motif domain containing | 0.978 |
| BST2 | SERINC3 | ENSP00000252593 | ENSP00000340243 | Bone marrow stromal antigen 2; IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae- h [...] | Serine incorporator 3; Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1- acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm; Belongs to the TDE1 family | 0.491 |
| CLGN | ADAM2 | ENSP00000326699 | ENSP00000265708 | Calmegin; Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions (By similarity) | Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein; ADAM metallopeptidase domain containing | 0.939 |
| CLGN | SERINC3 | ENSP00000326699 | ENSP00000340243 | Calmegin; Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions (By similarity) | Serine incorporator 3; Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1- acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm; Belongs to the TDE1 family | 0.716 |
| DDT | SERINC3 | ENSP00000381386 | ENSP00000340243 | D-dopachrome decarboxylase; Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI) | Serine incorporator 3; Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1- acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm; Belongs to the TDE1 family | 0.700 |
| GLRX | GRXCR1 | ENSP00000369314 | ENSP00000382670 | Glutaredoxin-1; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins; Glutaredoxin domain containing | Glutaredoxin domain-containing cysteine-rich protein 1; May play a role in actin filament architecture in developing stereocilia of sensory cells; Glutaredoxin domain containing | 0.763 |
| GLRX | SERINC3 | ENSP00000369314 | ENSP00000340243 | Glutaredoxin-1; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins; Glutaredoxin domain containing | Serine incorporator 3; Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1- acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm; Belongs to the TDE1 family | 0.533 |
| GRXCR1 | GLRX | ENSP00000382670 | ENSP00000369314 | Glutaredoxin domain-containing cysteine-rich protein 1; May play a role in actin filament architecture in developing stereocilia of sensory cells; Glutaredoxin domain containing | Glutaredoxin-1; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins; Glutaredoxin domain containing | 0.763 |
| GRXCR1 | SERINC3 | ENSP00000382670 | ENSP00000340243 | Glutaredoxin domain-containing cysteine-rich protein 1; May play a role in actin filament architecture in developing stereocilia of sensory cells; Glutaredoxin domain containing | Serine incorporator 3; Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1- acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm; Belongs to the TDE1 family | 0.905 |
| IBTK | SERINC3 | ENSP00000305721 | ENSP00000340243 | Inhibitor of Bruton tyrosine kinase; Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription; Ankyrin repeat domain containing | Serine incorporator 3; Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1- acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm; Belongs to the TDE1 family | 0.584 |
| PTPN11 | SAMD14 | ENSP00000340944 | ENSP00000424474 | Tyrosine-protein phosphatase non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at ’Tyr-722’ resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73; Protein tyrosine phosphatases, non-receptor type | Sterile alpha motif domain containing 14 | 0.405 |
| PTPN11 | SERINC3 | ENSP00000340944 | ENSP00000340243 | Tyrosine-protein phosphatase non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at ’Tyr-722’ resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73; Protein tyrosine phosphatases, non-receptor type | Serine incorporator 3; Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1- acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm; Belongs to the TDE1 family | 0.511 |
| SAMD14 | PTPN11 | ENSP00000424474 | ENSP00000340944 | Sterile alpha motif domain containing 14 | Tyrosine-protein phosphatase non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at ’Tyr-722’ resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73; Protein tyrosine phosphatases, non-receptor type | 0.405 |
| SAMD14 | SERINC3 | ENSP00000424474 | ENSP00000340243 | Sterile alpha motif domain containing 14 | Serine incorporator 3; Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1- acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm; Belongs to the TDE1 family | 0.513 |
| SAMHD1 | BST2 | ENSP00000262878 | ENSP00000252593 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1; Host restriction nuclease involved in defense response to virus. Has dNTPase activity and reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur. Blocks early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. May play a role in mediating proinflammatory responses to TNF-alpha signaling. Has ribonuclease activity, acting on single-stranded RNA. This activity is essential for H1V-1 restriction; Sterile alpha motif domain containing | Bone marrow stromal antigen 2; IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae- h [...] | 0.978 |
| SAMHD1 | SERINC3 | ENSP00000262878 | ENSP00000340243 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1; Host restriction nuclease involved in defense response to virus. Has dNTPase activity and reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur. Blocks early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. May play a role in mediating proinflammatory responses to TNF-alpha signaling. Has ribonuclease activity, acting on single-stranded RNA. This activity is essential for H1V-1 restriction; Sterile alpha motif domain containing | Serine incorporator 3; Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1- acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm; Belongs to the TDE1 family | 0.499 |
| SERINC3 | ADAM2 | ENSP00000340243 | ENSP00000265708 | Serine incorporator 3; Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1- acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm; Belongs to the TDE1 family | Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein; ADAM metallopeptidase domain containing | 0.527 |
| SERINC3 | BST2 | ENSP00000340243 | ENSP00000252593 | Serine incorporator 3; Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1- acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm; Belongs to the TDE1 family | Bone marrow stromal antigen 2; IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae- h [...] | 0.491 |
