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STRINGSTRING
TACC2 TACC2 LRRC66 LRRC66 TMEM91 TMEM91 C19orf54 C19orf54 ZFAND4 ZFAND4 C19orf47 C19orf47 ZNF546 ZNF546 TIGD2 TIGD2 TTC9B TTC9B TRIM28 TRIM28 CCDC42 CCDC42
"ZNF546" - Zinc finger protein 546 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
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Coexpression
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[Homology]
Score
ZNF546Zinc finger protein 546; May be involved in transcriptional regulation; Zinc fingers C2H2-type (836 aa)    
Predicted Functional Partners:
TRIM28
Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] (835 aa)
      
  0.904
CCDC42
Coiled-coil domain-containing protein 42; Required for sperm development (316 aa)
            
  0.565
LRRC66
Leucine-rich repeat-containing protein 66; Leucine rich repeat containing 66 (880 aa)
        
 
  0.555
ZFAND4
Zinc finger AN1-type containing 4 (727 aa)
      
 
  0.548
C19orf47
Uncharacterized protein C19orf47; Chromosome 19 open reading frame 47 (422 aa)
            
  0.540
TIGD2
Tigger transposable element-derived protein 2; Helix-turn-helix CENPB type domain containing; DNA transposon derived genes (525 aa)
        
 
  0.533
C19orf54
UPF0692 protein C19orf54; Chromosome 19 open reading frame 54; Belongs to the UPF0692 family (351 aa)
            
  0.530
TACC2
Transforming acidic coiled-coil-containing protein 2; Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker (2948 aa)
        
 
  0.511
TTC9B
Tetratricopeptide repeat domain containing (239 aa)
            
  0.489
TMEM91
Interferon induced transmembrane protein domain containing; Belongs to the CD225/Dispanin family (172 aa)
            
  0.479
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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