node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GUSB | HYAL1 | ENSP00000302728 | ENSP00000266031 | Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family | Hyaluronidase-1; May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth | 0.930 |
GUSB | IDS | ENSP00000302728 | ENSP00000339801 | Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family | Iduronate 2-sulfatase; Required for the lysosomal degradation of heparan sulfate and dermatan sulfate; Sulfatases | 0.722 |
GUSB | IDUA | ENSP00000302728 | ENSP00000247933 | Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family | Alpha-L-iduronidase; Iduronidase, alpha-L- | 0.722 |
GUSB | SPAM1 | ENSP00000302728 | ENSP00000345849 | Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family | Hyaluronidase PH-20; Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid; Belongs to the glycosyl hydrolase 56 family | 0.933 |
HPSE | HPSE2 | ENSP00000384262 | ENSP00000359583 | Heparanase; Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at ne [...] | Inactive heparanase-2; Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro) | 0.812 |
HPSE | IDS | ENSP00000384262 | ENSP00000339801 | Heparanase; Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at ne [...] | Iduronate 2-sulfatase; Required for the lysosomal degradation of heparan sulfate and dermatan sulfate; Sulfatases | 0.923 |
HPSE2 | HPSE | ENSP00000359583 | ENSP00000384262 | Inactive heparanase-2; Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro) | Heparanase; Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at ne [...] | 0.812 |
HPSE2 | IDS | ENSP00000359583 | ENSP00000339801 | Inactive heparanase-2; Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro) | Iduronate 2-sulfatase; Required for the lysosomal degradation of heparan sulfate and dermatan sulfate; Sulfatases | 0.906 |
HYAL1 | GUSB | ENSP00000266031 | ENSP00000302728 | Hyaluronidase-1; May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth | Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family | 0.930 |
HYAL1 | IDS | ENSP00000266031 | ENSP00000339801 | Hyaluronidase-1; May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth | Iduronate 2-sulfatase; Required for the lysosomal degradation of heparan sulfate and dermatan sulfate; Sulfatases | 0.911 |
HYAL1 | IDUA | ENSP00000266031 | ENSP00000247933 | Hyaluronidase-1; May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth | Alpha-L-iduronidase; Iduronidase, alpha-L- | 0.923 |
IDS | GUSB | ENSP00000339801 | ENSP00000302728 | Iduronate 2-sulfatase; Required for the lysosomal degradation of heparan sulfate and dermatan sulfate; Sulfatases | Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family | 0.722 |
IDS | HPSE | ENSP00000339801 | ENSP00000384262 | Iduronate 2-sulfatase; Required for the lysosomal degradation of heparan sulfate and dermatan sulfate; Sulfatases | Heparanase; Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at ne [...] | 0.923 |
IDS | HPSE2 | ENSP00000339801 | ENSP00000359583 | Iduronate 2-sulfatase; Required for the lysosomal degradation of heparan sulfate and dermatan sulfate; Sulfatases | Inactive heparanase-2; Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro) | 0.906 |
IDS | HYAL1 | ENSP00000339801 | ENSP00000266031 | Iduronate 2-sulfatase; Required for the lysosomal degradation of heparan sulfate and dermatan sulfate; Sulfatases | Hyaluronidase-1; May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth | 0.911 |
IDS | IDUA | ENSP00000339801 | ENSP00000247933 | Iduronate 2-sulfatase; Required for the lysosomal degradation of heparan sulfate and dermatan sulfate; Sulfatases | Alpha-L-iduronidase; Iduronidase, alpha-L- | 0.970 |
IDS | MITD1 | ENSP00000339801 | ENSP00000289359 | Iduronate 2-sulfatase; Required for the lysosomal degradation of heparan sulfate and dermatan sulfate; Sulfatases | MIT domain-containing protein 1; Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex | 0.641 |
IDS | PGRMC1 | ENSP00000339801 | ENSP00000217971 | Iduronate 2-sulfatase; Required for the lysosomal degradation of heparan sulfate and dermatan sulfate; Sulfatases | Membrane-associated progesterone receptor component 1; Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs); Belongs to the cytochrome b5 family. MAPR subfamily | 0.624 |
IDS | SPAM1 | ENSP00000339801 | ENSP00000345849 | Iduronate 2-sulfatase; Required for the lysosomal degradation of heparan sulfate and dermatan sulfate; Sulfatases | Hyaluronidase PH-20; Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid; Belongs to the glycosyl hydrolase 56 family | 0.904 |
IDS | SUMF1 | ENSP00000339801 | ENSP00000272902 | Iduronate 2-sulfatase; Required for the lysosomal degradation of heparan sulfate and dermatan sulfate; Sulfatases | Sulfatase-modifying factor 1; Using molecular oxygen and an unidentified reducing agent, oxidizes a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also called C(alpha)-formylglycine. Known substrates include GALNS, ARSA, STS and ARSE; Belongs to the sulfatase-modifying factor family | 0.872 |