node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MST1 | RASSF2 | ENSP00000414287 | ENSP00000368710 | Hepatocyte growth factor-like protein; Macrophage stimulating 1 | Ras association domain-containing protein 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation; Ras association domain family | 0.554 |
MST1 | RASSF3 | ENSP00000414287 | ENSP00000443021 | Hepatocyte growth factor-like protein; Macrophage stimulating 1 | Ras association domain family member 3 | 0.538 |
MST1 | RASSF4 | ENSP00000414287 | ENSP00000339692 | Hepatocyte growth factor-like protein; Macrophage stimulating 1 | Ras association domain-containing protein 4; Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest; Ras association domain family | 0.523 |
MST1 | RASSF5 | ENSP00000414287 | ENSP00000462099 | Hepatocyte growth factor-like protein; Macrophage stimulating 1 | Ras association domain-containing protein 5; Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras [...] | 0.678 |
MST1 | SAV1 | ENSP00000414287 | ENSP00000324729 | Hepatocyte growth factor-like protein; Macrophage stimulating 1 | Protein salvador homolog 1; Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleu [...] | 0.681 |
MST1 | STK3 | ENSP00000414287 | ENSP00000429744 | Hepatocyte growth factor-like protein; Macrophage stimulating 1 | Serine/threonine-protein kinase 3; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein [...] | 0.767 |
MST1 | STK4 | ENSP00000414287 | ENSP00000361892 | Hepatocyte growth factor-like protein; Macrophage stimulating 1 | Serine/threonine-protein kinase 4; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein [...] | 0.792 |
RASSF10 | RASSF2 | ENSP00000485526 | ENSP00000368710 | Ras association domain family member 10 | Ras association domain-containing protein 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation; Ras association domain family | 0.683 |
RASSF10 | RASSF3 | ENSP00000485526 | ENSP00000443021 | Ras association domain family member 10 | Ras association domain family member 3 | 0.695 |
RASSF10 | RASSF4 | ENSP00000485526 | ENSP00000339692 | Ras association domain family member 10 | Ras association domain-containing protein 4; Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest; Ras association domain family | 0.533 |
RASSF10 | RASSF5 | ENSP00000485526 | ENSP00000462099 | Ras association domain family member 10 | Ras association domain-containing protein 5; Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras [...] | 0.662 |
RASSF10 | RASSF7 | ENSP00000485526 | ENSP00000380713 | Ras association domain family member 10 | Ras association domain-containing protein 7; Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti- apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization; Ras association domain family | 0.863 |
RASSF10 | RASSF8 | ENSP00000485526 | ENSP00000384491 | Ras association domain family member 10 | Ras association domain family member 8 | 0.865 |
RASSF2 | MST1 | ENSP00000368710 | ENSP00000414287 | Ras association domain-containing protein 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation; Ras association domain family | Hepatocyte growth factor-like protein; Macrophage stimulating 1 | 0.554 |
RASSF2 | RASSF10 | ENSP00000368710 | ENSP00000485526 | Ras association domain-containing protein 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation; Ras association domain family | Ras association domain family member 10 | 0.683 |
RASSF2 | RASSF3 | ENSP00000368710 | ENSP00000443021 | Ras association domain-containing protein 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation; Ras association domain family | Ras association domain family member 3 | 0.632 |
RASSF2 | RASSF4 | ENSP00000368710 | ENSP00000339692 | Ras association domain-containing protein 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation; Ras association domain family | Ras association domain-containing protein 4; Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest; Ras association domain family | 0.814 |
RASSF2 | RASSF5 | ENSP00000368710 | ENSP00000462099 | Ras association domain-containing protein 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation; Ras association domain family | Ras association domain-containing protein 5; Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras [...] | 0.660 |
RASSF2 | RASSF7 | ENSP00000368710 | ENSP00000380713 | Ras association domain-containing protein 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation; Ras association domain family | Ras association domain-containing protein 7; Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti- apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization; Ras association domain family | 0.813 |
RASSF2 | RASSF8 | ENSP00000368710 | ENSP00000384491 | Ras association domain-containing protein 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation; Ras association domain family | Ras association domain family member 8 | 0.498 |