• Version:
  • 11.0 [archived version]
STRINGSTRING
COL2A1 COL2A1 GTF2IRD2B GTF2IRD2B GTF2IRD2 GTF2IRD2 PRRC2B PRRC2B SEC14L5 SEC14L5 IRF2BPL IRF2BPL KRBOX4 KRBOX4 ZNF449 ZNF449 WIPF3 WIPF3 ZNF395 ZNF395 ZNF608 ZNF608
"ZNF449" - Zinc finger protein 449 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZNF449Zinc finger protein 449; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family (518 aa)    
Predicted Functional Partners:
KRBOX4
KRAB box domain containing 4 (171 aa)
           
  0.585
SEC14L5
SEC14-like protein 5; SEC14 like lipid binding 5; PRELI domain containing (696 aa)
     
 
  0.526
ZNF608
Zinc finger protein 608; Transcription factor, which represses ZNF609 transcription; Zinc fingers C2H2-type (1512 aa)
           
  0.522
PRRC2B
Protein PRRC2B; Proline rich coiled-coil 2B (2229 aa)
     
   
  0.484
IRF2BPL
Interferon regulatory factor 2-binding protein-like; May contribute to the control of female reproductive function (By similarity). May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter; Belongs to the IRF2BP family (796 aa)
       
 
  0.469
GTF2IRD2
General transcription factor II-I repeat domain-containing protein 2A; GTF2I repeat domain containing 2 (949 aa)
     
   
  0.465
WIPF3
WAS/WASL-interacting protein family member 3; May be a regulator of cytoskeletal organization. May have a role in spermatogenesis (By similarity); Belongs to the verprolin family (483 aa)
       
 
  0.454
COL2A1
Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces (1487 aa)
           
  0.451
GTF2IRD2B
General transcription factor II-I repeat domain-containing protein 2B; GTF2I repeat domain containing 2B; Belongs to the TFII-I family (949 aa)
     
   
  0.433
ZNF395
Zinc finger protein 395; Plays a role in papillomavirus genes transcription; Zinc fingers C2H2-type (513 aa)
           
  0.433
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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