node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CLC | LGALS12 | ENSP00000221804 | ENSP00000339374 | Galectin-10; Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg); Galectins | Galectin-12; Binds lactose. May participate in the apoptosis of adipocytes; Galectins | 0.604 |
HAPLN1 | LGALS12 | ENSP00000274341 | ENSP00000339374 | Hyaluronan and proteoglycan link protein 1; Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix; V-set domain containing | Galectin-12; Binds lactose. May participate in the apoptosis of adipocytes; Galectins | 0.653 |
HAPLN1 | RYR3 | ENSP00000274341 | ENSP00000373884 | Hyaluronan and proteoglycan link protein 1; Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix; V-set domain containing | Ryanodine receptor 3; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca(2+) release by other calcium channels. Calcium channel that mediates Ca(2+)-induced Ca(2+) release from the endoplasmic reticulum in non-muscle cells. Contributes to cellular calcium ion homeostasis (By similarity). Plays a role in cellular calcium signaling; EF-hand domain containing | 0.409 |
HAPLN1 | SLC7A2 | ENSP00000274341 | ENSP00000004531 | Hyaluronan and proteoglycan link protein 1; Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix; V-set domain containing | Cationic amino acid transporter 2; Functions as permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine); the affinity for its substrates differs between isoforms created by alternative splicing. Isoform 1 functions as permease that mediates the transport of the cationic amino acids (arginine, lysine and ornithine), and it has much higher affinity for arginine than isoform 2. Isoform 2 functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine). May play a role in classic [...] | 0.510 |
LGALS12 | CLC | ENSP00000339374 | ENSP00000221804 | Galectin-12; Binds lactose. May participate in the apoptosis of adipocytes; Galectins | Galectin-10; Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg); Galectins | 0.604 |
LGALS12 | HAPLN1 | ENSP00000339374 | ENSP00000274341 | Galectin-12; Binds lactose. May participate in the apoptosis of adipocytes; Galectins | Hyaluronan and proteoglycan link protein 1; Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix; V-set domain containing | 0.653 |
LGALS12 | LGALS13 | ENSP00000339374 | ENSP00000221797 | Galectin-12; Binds lactose. May participate in the apoptosis of adipocytes; Galectins | Galactoside-binding soluble lectin 13; Binds beta-galactoside and lactose. Strong inducer of T- cell apoptosis; Galectins | 0.577 |
LGALS12 | RYR3 | ENSP00000339374 | ENSP00000373884 | Galectin-12; Binds lactose. May participate in the apoptosis of adipocytes; Galectins | Ryanodine receptor 3; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca(2+) release by other calcium channels. Calcium channel that mediates Ca(2+)-induced Ca(2+) release from the endoplasmic reticulum in non-muscle cells. Contributes to cellular calcium ion homeostasis (By similarity). Plays a role in cellular calcium signaling; EF-hand domain containing | 0.452 |
LGALS12 | SLC7A2 | ENSP00000339374 | ENSP00000004531 | Galectin-12; Binds lactose. May participate in the apoptosis of adipocytes; Galectins | Cationic amino acid transporter 2; Functions as permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine); the affinity for its substrates differs between isoforms created by alternative splicing. Isoform 1 functions as permease that mediates the transport of the cationic amino acids (arginine, lysine and ornithine), and it has much higher affinity for arginine than isoform 2. Isoform 2 functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine). May play a role in classic [...] | 0.496 |
LGALS12 | VPS13C | ENSP00000339374 | ENSP00000261517 | Galectin-12; Binds lactose. May participate in the apoptosis of adipocytes; Galectins | Vacuolar protein sorting-associated protein 13C; Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential. Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization | 0.847 |
LGALS13 | LGALS12 | ENSP00000221797 | ENSP00000339374 | Galactoside-binding soluble lectin 13; Binds beta-galactoside and lactose. Strong inducer of T- cell apoptosis; Galectins | Galectin-12; Binds lactose. May participate in the apoptosis of adipocytes; Galectins | 0.577 |
RYR3 | HAPLN1 | ENSP00000373884 | ENSP00000274341 | Ryanodine receptor 3; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca(2+) release by other calcium channels. Calcium channel that mediates Ca(2+)-induced Ca(2+) release from the endoplasmic reticulum in non-muscle cells. Contributes to cellular calcium ion homeostasis (By similarity). Plays a role in cellular calcium signaling; EF-hand domain containing | Hyaluronan and proteoglycan link protein 1; Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix; V-set domain containing | 0.409 |
RYR3 | LGALS12 | ENSP00000373884 | ENSP00000339374 | Ryanodine receptor 3; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca(2+) release by other calcium channels. Calcium channel that mediates Ca(2+)-induced Ca(2+) release from the endoplasmic reticulum in non-muscle cells. Contributes to cellular calcium ion homeostasis (By similarity). Plays a role in cellular calcium signaling; EF-hand domain containing | Galectin-12; Binds lactose. May participate in the apoptosis of adipocytes; Galectins | 0.452 |
SLC7A2 | HAPLN1 | ENSP00000004531 | ENSP00000274341 | Cationic amino acid transporter 2; Functions as permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine); the affinity for its substrates differs between isoforms created by alternative splicing. Isoform 1 functions as permease that mediates the transport of the cationic amino acids (arginine, lysine and ornithine), and it has much higher affinity for arginine than isoform 2. Isoform 2 functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine). May play a role in classic [...] | Hyaluronan and proteoglycan link protein 1; Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix; V-set domain containing | 0.510 |
SLC7A2 | LGALS12 | ENSP00000004531 | ENSP00000339374 | Cationic amino acid transporter 2; Functions as permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine); the affinity for its substrates differs between isoforms created by alternative splicing. Isoform 1 functions as permease that mediates the transport of the cationic amino acids (arginine, lysine and ornithine), and it has much higher affinity for arginine than isoform 2. Isoform 2 functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine). May play a role in classic [...] | Galectin-12; Binds lactose. May participate in the apoptosis of adipocytes; Galectins | 0.496 |
VPS13C | LGALS12 | ENSP00000261517 | ENSP00000339374 | Vacuolar protein sorting-associated protein 13C; Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential. Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization | Galectin-12; Binds lactose. May participate in the apoptosis of adipocytes; Galectins | 0.847 |