| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| B7RP1 | IL2RA | ENSP00000339477 | ENSP00000369293 | Inducible T-cell co-stimulator ligand; Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function (By similarity); Belongs to the immunoglobulin superfamily. BTN/MOG family | Interleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells; CD molecules | 0.415 |
| B7RP1 | KLRG2 | ENSP00000339477 | ENSP00000339356 | Inducible T-cell co-stimulator ligand; Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function (By similarity); Belongs to the immunoglobulin superfamily. BTN/MOG family | Killer cell lectin like receptor G2; C-type lectin domain containing | 0.579 |
| C7orf33 | KLRG2 | ENSP00000304071 | ENSP00000339356 | Uncharacterized protein C7orf33; Chromosome 7 open reading frame 33 | Killer cell lectin like receptor G2; C-type lectin domain containing | 0.577 |
| C7orf33 | UBN2 | ENSP00000304071 | ENSP00000418648 | Uncharacterized protein C7orf33; Chromosome 7 open reading frame 33 | Ubinuclein-2; Ubinuclein 2; Belongs to the ubinuclein family | 0.558 |
| FCER1G | FCGRT | ENSP00000289902 | ENSP00000221466 | High affinity immunoglobulin epsilon receptor subunit gamma; Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin; Belongs to the CD3Z/FCER1G family | IgG receptor FcRn large subunit p51; Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the selective uptake of IgG from milk and helps newborn animals to acquire passive immunity. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids (By similarity). Possible role in transfer of immunoglobulin G from mother to fetus | 0.411 |
| FCER1G | KLRG2 | ENSP00000289902 | ENSP00000339356 | High affinity immunoglobulin epsilon receptor subunit gamma; Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin; Belongs to the CD3Z/FCER1G family | Killer cell lectin like receptor G2; C-type lectin domain containing | 0.560 |
| FCGRT | FCER1G | ENSP00000221466 | ENSP00000289902 | IgG receptor FcRn large subunit p51; Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the selective uptake of IgG from milk and helps newborn animals to acquire passive immunity. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids (By similarity). Possible role in transfer of immunoglobulin G from mother to fetus | High affinity immunoglobulin epsilon receptor subunit gamma; Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin; Belongs to the CD3Z/FCER1G family | 0.411 |
| FCGRT | KLRG2 | ENSP00000221466 | ENSP00000339356 | IgG receptor FcRn large subunit p51; Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the selective uptake of IgG from milk and helps newborn animals to acquire passive immunity. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids (By similarity). Possible role in transfer of immunoglobulin G from mother to fetus | Killer cell lectin like receptor G2; C-type lectin domain containing | 0.668 |
| ICOSL | IL2RA | ENSP00000483732 | ENSP00000369293 | ICOS ligand; Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function (By similarity); Belongs to the immunoglobulin superfamily. BTN/MOG family | Interleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells; CD molecules | 0.414 |
| ICOSL | KLRG2 | ENSP00000483732 | ENSP00000339356 | ICOS ligand; Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function (By similarity); Belongs to the immunoglobulin superfamily. BTN/MOG family | Killer cell lectin like receptor G2; C-type lectin domain containing | 0.579 |
| IL2RA | B7RP1 | ENSP00000369293 | ENSP00000339477 | Interleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells; CD molecules | Inducible T-cell co-stimulator ligand; Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function (By similarity); Belongs to the immunoglobulin superfamily. BTN/MOG family | 0.415 |
| IL2RA | ICOSL | ENSP00000369293 | ENSP00000483732 | Interleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells; CD molecules | ICOS ligand; Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function (By similarity); Belongs to the immunoglobulin superfamily. BTN/MOG family | 0.414 |
| IL2RA | KLRG2 | ENSP00000369293 | ENSP00000339356 | Interleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells; CD molecules | Killer cell lectin like receptor G2; C-type lectin domain containing | 0.638 |
| JSRP1 | KLRG2 | ENSP00000300961 | ENSP00000339356 | Junctional sarcoplasmic reticulum protein 1; Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage- sensitive calcium channel CACNA1S. EC is a physiological process whereby an electrical signal (depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening of ryanodine receptor calcium release channels. May regulate CACNA1S membrane targeting and activity | Killer cell lectin like receptor G2; C-type lectin domain containing | 0.580 |
| JSRP1 | RWDD2B | ENSP00000300961 | ENSP00000418693 | Junctional sarcoplasmic reticulum protein 1; Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage- sensitive calcium channel CACNA1S. EC is a physiological process whereby an electrical signal (depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening of ryanodine receptor calcium release channels. May regulate CACNA1S membrane targeting and activity | RWD domain containing 2B | 0.700 |
| JSRP1 | UBN2 | ENSP00000300961 | ENSP00000418648 | Junctional sarcoplasmic reticulum protein 1; Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage- sensitive calcium channel CACNA1S. EC is a physiological process whereby an electrical signal (depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening of ryanodine receptor calcium release channels. May regulate CACNA1S membrane targeting and activity | Ubinuclein-2; Ubinuclein 2; Belongs to the ubinuclein family | 0.682 |
| JSRP1 | USP16 | ENSP00000300961 | ENSP00000334808 | Junctional sarcoplasmic reticulum protein 1; Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage- sensitive calcium channel CACNA1S. EC is a physiological process whereby an electrical signal (depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening of ryanodine receptor calcium release channels. May regulate CACNA1S membrane targeting and activity | Ubiquitin carboxyl-terminal hydrolase 16; Specifically deubiquitinates ’Lys-120’ of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at ’Ser-11’ of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T- lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiq [...] | 0.537 |
| KLRG2 | B7RP1 | ENSP00000339356 | ENSP00000339477 | Killer cell lectin like receptor G2; C-type lectin domain containing | Inducible T-cell co-stimulator ligand; Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function (By similarity); Belongs to the immunoglobulin superfamily. BTN/MOG family | 0.579 |
| KLRG2 | C7orf33 | ENSP00000339356 | ENSP00000304071 | Killer cell lectin like receptor G2; C-type lectin domain containing | Uncharacterized protein C7orf33; Chromosome 7 open reading frame 33 | 0.577 |
| KLRG2 | FCER1G | ENSP00000339356 | ENSP00000289902 | Killer cell lectin like receptor G2; C-type lectin domain containing | High affinity immunoglobulin epsilon receptor subunit gamma; Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin; Belongs to the CD3Z/FCER1G family | 0.560 |
