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STRINGSTRING
ZNF69 ZNF69 CORT CORT TRIM28 TRIM28 ZNF70 ZNF70 LRRC75B LRRC75B C22orf15 C22orf15 HIST1H1A HIST1H1A GUCD1 GUCD1 RGL4 RGL4 DRICH1 DRICH1 SPECC1L SPECC1L
"ZNF70" - Zinc finger protein 70 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ZNF70Zinc finger protein 70; May be involved in transcriptional regulation; Zinc fingers C2H2-type (446 aa)    
Predicted Functional Partners:
ZNF69
Zinc finger protein 69; Zinc fingers C2H2-type (149 aa)
            
  0.907
TRIM28
Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] (835 aa)
      
    0.903
LRRC75B
Leucine-rich repeat-containing protein 75B; Leucine rich repeat containing 75B (315 aa)
            
  0.669
GUCD1
Protein GUCD1; Guanylyl cyclase domain containing 1 (296 aa)
            
  0.651
C22orf15
Uncharacterized protein C22orf15; Chromosome 22 open reading frame 15 (148 aa)
            
  0.645
DRICH1
Aspartate-rich protein 1; Aspartate rich 1 (229 aa)
            
  0.584
HIST1H1A
Histone H1.1; Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity) (215 aa)
        
      0.556
RGL4
Ral-GDS-related protein; Ral guanine nucleotide dissociation stimulator like 4 (473 aa)
            
  0.542
CORT
Cortistatin; Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs; Endogenous ligands (105 aa)
            
  0.503
SPECC1L
Cytospin-A; Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration; Belongs to the cytospin-A family (1117 aa)
        
 
  0.477
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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