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STRINGSTRING
ATRN ATRN DPEP2 DPEP2 DPP7 DPP7 PREPL PREPL TFDP3 TFDP3 PREP PREP DPP8 DPP8 PRCP PRCP HRK HRK GCG GCG GIP GIP
"DPP8" - Dipeptidyl peptidase 8 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
Coexpression
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[Homology]
Score
DPP8Dipeptidyl peptidase 8; Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. May play a role in T-cell activation and immune function; Belongs to the peptidase S9B family. DPPIV subfamily (898 aa)    
Predicted Functional Partners:
DPP7
Dipeptidyl peptidase 2; Plays an important role in the degradation of some oligopeptides; DASH family (492 aa)
      
   
  0.864
PREP
Prolyl endopeptidase; Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long; Belongs to the peptidase S9A family (710 aa)
      
   
  0.859
TFDP3
Transcription factor Dp family member 3; Competitive inhibitor of E2F-mediated transactivation activity. Impairs E2F-mediated cell-cycle progression from G(1) to S phase; Belongs to the E2F/DP family (405 aa)
      
   
  0.842
HRK
Activator of apoptosis harakiri; Promotes apoptosis; BCL2 homology region 3 only (91 aa)
            
  0.615
PREPL
Prolyl endopeptidase-like; Probable serine peptidase whose precise substrate specificity remains unclear. Does not cleave peptides after a arginine or lysine residue. May play a role in the regulation of synaptic vesiscle exocytosis (727 aa)
      
   
  0.588
PRCP
Lysosomal Pro-X carboxypeptidase; Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH; M14 carboxypeptidases (517 aa)
      
   
  0.578
GCG
Glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life; Belongs to the glucagon family (180 aa)
      
   
  0.569
GIP
Gastric inhibitory polypeptide; Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion; Endogenous ligands (153 aa)
            
  0.545
ATRN
Attractin; Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system (By similarity); C-type lectin domain containing (1429 aa)
      
   
  0.516
DPEP2
Dipeptidase 2; Probable metalloprotease which hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4) (486 aa)
 
   
  0.516
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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