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FAM102A FAM102A C11orf30 C11orf30 DCAF7 DCAF7 RPL36A RPL36A PAGE2B PAGE2B AIDA AIDA GRM8 GRM8 DHRS7 DHRS7 NAT14 NAT14 AXIN1 AXIN1 GSK3B GSK3B
"AIDA" - Axin interactor, dorsalization-associated protein in Homo sapiens
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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AIDAAxin interactor, dorsalization-associated protein; Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity); C2 domain containing (306 aa)    
Predicted Functional Partners:
C11orf30
BRCA2-interacting transcriptional repressor EMSY; Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors (1337 aa)
       
      0.800
DCAF7
DDB1- and CUL4-associated factor 7; Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4- DDB1 E3 ubiquitin-protein ligase complex; Belongs to the WD repeat DCAF7 family (342 aa)
           
  0.620
PAGE2B
PAGE family member 2B; Belongs to the GAGE family (111 aa)
           
  0.552
RPL36A
Ribosomal protein L36a (142 aa)
       
      0.544
GRM8
Metabotropic glutamate receptor 8; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (908 aa)
           
  0.525
GSK3B
Glycogen synthase kinase-3 beta; Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glyc [...] (433 aa)
           
  0.499
AXIN1
Axin-1; Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin li [...] (862 aa)
       
 
  0.487
FAM102A
Protein FAM102A; May play a role in estrogen action; Belongs to the FAM102 family (384 aa)
           
  0.473
NAT14
N-acetyltransferase 14; Probable acetyltransferase that binds the 5’-GGACTACAG- 3’ sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro; GCN5 related N-acetyltransferases (206 aa)
           
  0.473
DHRS7
Dehydrogenase/reductase SDR family member 7; Short chain dehydrogenase/reductase superfamily (339 aa)
           
  0.443
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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