CRISP2 protein (human) - STRING database

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CRISP2

Cysteine-rich secretory protein 2; May regulate some ion channels’ activity and therebye regulate calcium fluxes during sperm capacitation; Cysteine rich secretory protein family (243 aa)

Predicted Functional Partners:

PGK2

0.910

FMR1NB

0.676

FTHL17

0.631

SHPK

0.630

DKKL1

0.606

MORC1

0.600

EMR3

0.581

SPO11

0.556

SPA17

0.553

TMEM37

0.545

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRISP2	DKKL1	ENSP00000339155	ENSP00000221498	Cysteine-rich secretory protein 2; May regulate some ion channels’ activity and therebye regulate calcium fluxes during sperm capacitation; Cysteine rich secretory protein family	Dickkopf-like protein 1; Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promotes spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduces testosterone synthesis in Leydig cells. Is not essential either for development or fertility	0.606
CRISP2	EMR3	ENSP00000339155	ENSP00000253673	Cysteine-rich secretory protein 2; May regulate some ion channels’ activity and therebye regulate calcium fluxes during sperm capacitation; Cysteine rich secretory protein family	Adhesion G protein-coupled receptor E3; Orphan receptor that may play a role myeloid-myeloid interactions during immune and inflammatory responses. A ligand for the soluble form of this receptor is present at the surface of monocytes-derived macrophages and activated neutrophils; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily	0.581
CRISP2	FMR1NB	ENSP00000339155	ENSP00000359498	Cysteine-rich secretory protein 2; May regulate some ion channels’ activity and therebye regulate calcium fluxes during sperm capacitation; Cysteine rich secretory protein family	Fragile X mental retardation 1 neighbor protein; FMR1 neighbor	0.676
CRISP2	FTHL17	ENSP00000339155	ENSP00000368207	Cysteine-rich secretory protein 2; May regulate some ion channels’ activity and therebye regulate calcium fluxes during sperm capacitation; Cysteine rich secretory protein family	Ferritin heavy chain like 17	0.631
CRISP2	MORC1	ENSP00000339155	ENSP00000232603	Cysteine-rich secretory protein 2; May regulate some ion channels’ activity and therebye regulate calcium fluxes during sperm capacitation; Cysteine rich secretory protein family	MORC family CW-type zinc finger protein 1; Required for spermatogenesis; Zinc fingers CW-type	0.600
CRISP2	PGK2	ENSP00000339155	ENSP00000305995	Cysteine-rich secretory protein 2; May regulate some ion channels’ activity and therebye regulate calcium fluxes during sperm capacitation; Cysteine rich secretory protein family	Phosphoglycerate kinase 2; Essential for sperm motility and male fertility. Not required for the completion of spermatogenesis (By similarity); Belongs to the phosphoglycerate kinase family	0.910
CRISP2	SHPK	ENSP00000339155	ENSP00000225519	Cysteine-rich secretory protein 2; May regulate some ion channels’ activity and therebye regulate calcium fluxes during sperm capacitation; Cysteine rich secretory protein family	Sedoheptulokinase; Acts as a modulator of macrophage activation through control of glucose metabolism	0.630
CRISP2	SPA17	ENSP00000339155	ENSP00000432305	Cysteine-rich secretory protein 2; May regulate some ion channels’ activity and therebye regulate calcium fluxes during sperm capacitation; Cysteine rich secretory protein family	Sperm surface protein Sp17; Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity)	0.553
CRISP2	SPO11	ENSP00000339155	ENSP00000360310	Cysteine-rich secretory protein 2; May regulate some ion channels’ activity and therebye regulate calcium fluxes during sperm capacitation; Cysteine rich secretory protein family	Meiotic recombination protein SPO11; Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with TOP6BL, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2	0.556
CRISP2	TMEM37	ENSP00000339155	ENSP00000303148	Cysteine-rich secretory protein 2; May regulate some ion channels’ activity and therebye regulate calcium fluxes during sperm capacitation; Cysteine rich secretory protein family	Voltage-dependent calcium channel gamma-like subunit; Thought to stabilize the calcium channel in an inactivated (closed) state. Modulates calcium current when coexpressed with CACNA1G (By similarity)	0.545
DKKL1	CRISP2	ENSP00000221498	ENSP00000339155	Dickkopf-like protein 1; Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promotes spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduces testosterone synthesis in Leydig cells. Is not essential either for development or fertility	Cysteine-rich secretory protein 2; May regulate some ion channels’ activity and therebye regulate calcium fluxes during sperm capacitation; Cysteine rich secretory protein family	0.606
DKKL1	FMR1NB	ENSP00000221498	ENSP00000359498	Dickkopf-like protein 1; Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promotes spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduces testosterone synthesis in Leydig cells. Is not essential either for development or fertility	Fragile X mental retardation 1 neighbor protein; FMR1 neighbor	0.598
DKKL1	FTHL17	ENSP00000221498	ENSP00000368207	Dickkopf-like protein 1; Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promotes spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduces testosterone synthesis in Leydig cells. Is not essential either for development or fertility	Ferritin heavy chain like 17	0.556
DKKL1	MORC1	ENSP00000221498	ENSP00000232603	Dickkopf-like protein 1; Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promotes spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduces testosterone synthesis in Leydig cells. Is not essential either for development or fertility	MORC family CW-type zinc finger protein 1; Required for spermatogenesis; Zinc fingers CW-type	0.439
DKKL1	SPA17	ENSP00000221498	ENSP00000432305	Dickkopf-like protein 1; Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promotes spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduces testosterone synthesis in Leydig cells. Is not essential either for development or fertility	Sperm surface protein Sp17; Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity)	0.429
DKKL1	SPO11	ENSP00000221498	ENSP00000360310	Dickkopf-like protein 1; Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promotes spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduces testosterone synthesis in Leydig cells. Is not essential either for development or fertility	Meiotic recombination protein SPO11; Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with TOP6BL, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2	0.548
EMR3	CRISP2	ENSP00000253673	ENSP00000339155	Adhesion G protein-coupled receptor E3; Orphan receptor that may play a role myeloid-myeloid interactions during immune and inflammatory responses. A ligand for the soluble form of this receptor is present at the surface of monocytes-derived macrophages and activated neutrophils; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily	Cysteine-rich secretory protein 2; May regulate some ion channels’ activity and therebye regulate calcium fluxes during sperm capacitation; Cysteine rich secretory protein family	0.581
FMR1NB	CRISP2	ENSP00000359498	ENSP00000339155	Fragile X mental retardation 1 neighbor protein; FMR1 neighbor	Cysteine-rich secretory protein 2; May regulate some ion channels’ activity and therebye regulate calcium fluxes during sperm capacitation; Cysteine rich secretory protein family	0.676
FMR1NB	DKKL1	ENSP00000359498	ENSP00000221498	Fragile X mental retardation 1 neighbor protein; FMR1 neighbor	Dickkopf-like protein 1; Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promotes spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduces testosterone synthesis in Leydig cells. Is not essential either for development or fertility	0.598
FMR1NB	FTHL17	ENSP00000359498	ENSP00000368207	Fragile X mental retardation 1 neighbor protein; FMR1 neighbor	Ferritin heavy chain like 17	0.642

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