RRP1B protein (human) - STRING database

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RRP1B

Ribosomal RNA processing protein 1 homolog B; Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1. Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus. Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure; B [...] (758 aa)

Predicted Functional Partners:

BOP1

0.988

EBNA1BP2

0.981

MAK16

0.978

WDR12

0.977

FTSJ3

0.975

RPF1

0.974

NOP2

0.973

PES1

0.973

NIFK

0.966

WDR74

0.966

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BOP1	EBNA1BP2	ENSP00000455106	ENSP00000407323	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA; Belongs to the EBP2 family	0.999
BOP1	FTSJ3	ENSP00000455106	ENSP00000396673	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily	0.993
BOP1	MAK16	ENSP00000455106	ENSP00000353246	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	Protein MAK16 homolog; RNA binding motif containing	0.985
BOP1	NIFK	ENSP00000455106	ENSP00000285814	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	Nucleolar protein interacting with the FHA domain of MKI67; RNA binding motif containing	0.990
BOP1	NOP2	ENSP00000455106	ENSP00000371858	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase; Involved in ribosomal large subunit assembly. S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (Probable); Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family	0.997
BOP1	PES1	ENSP00000455106	ENSP00000346725	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family	0.999
BOP1	RPF1	ENSP00000455106	ENSP00000359688	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	Ribosome production factor 1; May be required for ribosome biogenesis	0.990
BOP1	RRP1B	ENSP00000455106	ENSP00000339145	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	Ribosomal RNA processing protein 1 homolog B; Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1. Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus. Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure; B [...]	0.988
BOP1	WDR12	ENSP00000455106	ENSP00000261015	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; WD repeat domain containing	0.999
BOP1	WDR74	ENSP00000455106	ENSP00000432119	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	WD repeat-containing protein 74; WD repeat domain containing	0.993
EBNA1BP2	BOP1	ENSP00000407323	ENSP00000455106	Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA; Belongs to the EBP2 family	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family	0.999
EBNA1BP2	FTSJ3	ENSP00000407323	ENSP00000396673	Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA; Belongs to the EBP2 family	pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily	0.998
EBNA1BP2	MAK16	ENSP00000407323	ENSP00000353246	Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA; Belongs to the EBP2 family	Protein MAK16 homolog; RNA binding motif containing	0.997
EBNA1BP2	NIFK	ENSP00000407323	ENSP00000285814	Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA; Belongs to the EBP2 family	Nucleolar protein interacting with the FHA domain of MKI67; RNA binding motif containing	0.998
EBNA1BP2	NOP2	ENSP00000407323	ENSP00000371858	Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA; Belongs to the EBP2 family	Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase; Involved in ribosomal large subunit assembly. S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (Probable); Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family	0.998
EBNA1BP2	PES1	ENSP00000407323	ENSP00000346725	Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA; Belongs to the EBP2 family	Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family	0.999
EBNA1BP2	RPF1	ENSP00000407323	ENSP00000359688	Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA; Belongs to the EBP2 family	Ribosome production factor 1; May be required for ribosome biogenesis	0.994
EBNA1BP2	RRP1B	ENSP00000407323	ENSP00000339145	Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA; Belongs to the EBP2 family	Ribosomal RNA processing protein 1 homolog B; Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1. Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus. Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure; B [...]	0.981
EBNA1BP2	WDR12	ENSP00000407323	ENSP00000261015	Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA; Belongs to the EBP2 family	Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; WD repeat domain containing	0.999
EBNA1BP2	WDR74	ENSP00000407323	ENSP00000432119	Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA; Belongs to the EBP2 family	WD repeat-containing protein 74; WD repeat domain containing	0.992

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