node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BAG5 | HSPA13 | ENSP00000338814 | ENSP00000285667 | BAG family molecular chaperone regulator 5; Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding; BCL2 associated athanogene family | Heat shock 70 kDa protein 13; Has peptide-independent ATPase activity; Heat shock 70kDa proteins | 0.928 |
BAG5 | HSPA1A | ENSP00000338814 | ENSP00000364802 | BAG family molecular chaperone regulator 5; Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding; BCL2 associated athanogene family | Heat shock 70 kDa protein 1A; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and AD [...] | 0.992 |
BAG5 | HSPA1B | ENSP00000338814 | ENSP00000364801 | BAG family molecular chaperone regulator 5; Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding; BCL2 associated athanogene family | Heat shock protein family A member 1B | 0.985 |
BAG5 | HSPA1L | ENSP00000338814 | ENSP00000364805 | BAG family molecular chaperone regulator 5; Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding; BCL2 associated athanogene family | Heat shock 70 kDa protein 1-like; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis an [...] | 0.942 |
BAG5 | HSPA2 | ENSP00000338814 | ENSP00000378199 | BAG family molecular chaperone regulator 5; Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding; BCL2 associated athanogene family | Heat shock-related 70 kDa protein 2; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis [...] | 0.955 |
BAG5 | HSPA4 | ENSP00000338814 | ENSP00000302961 | BAG family molecular chaperone regulator 5; Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding; BCL2 associated athanogene family | Heat shock protein family A member 4; Belongs to the heat shock protein 70 family | 0.981 |
BAG5 | HSPA4L | ENSP00000338814 | ENSP00000296464 | BAG family molecular chaperone regulator 5; Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding; BCL2 associated athanogene family | Heat shock 70 kDa protein 4L; Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase; Belongs to the heat shock protein 70 family | 0.930 |
BAG5 | HSPA5 | ENSP00000338814 | ENSP00000324173 | BAG family molecular chaperone regulator 5; Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding; BCL2 associated athanogene family | 78 kDa glucose-regulated protein; Plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate (By similarity); Belongs to the heat shock protein 70 family | 0.955 |
BAG5 | HSPA8 | ENSP00000338814 | ENSP00000432083 | BAG family molecular chaperone regulator 5; Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding; BCL2 associated athanogene family | Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...] | 0.963 |
BAG5 | HSPA9 | ENSP00000338814 | ENSP00000297185 | BAG family molecular chaperone regulator 5; Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding; BCL2 associated athanogene family | Stress-70 protein, mitochondrial; Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging (By similarity); Belongs to the heat shock protein 70 family | 0.927 |
HSPA13 | BAG5 | ENSP00000285667 | ENSP00000338814 | Heat shock 70 kDa protein 13; Has peptide-independent ATPase activity; Heat shock 70kDa proteins | BAG family molecular chaperone regulator 5; Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding; BCL2 associated athanogene family | 0.928 |
HSPA13 | HSPA1A | ENSP00000285667 | ENSP00000364802 | Heat shock 70 kDa protein 13; Has peptide-independent ATPase activity; Heat shock 70kDa proteins | Heat shock 70 kDa protein 1A; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and AD [...] | 0.908 |
HSPA13 | HSPA1B | ENSP00000285667 | ENSP00000364801 | Heat shock 70 kDa protein 13; Has peptide-independent ATPase activity; Heat shock 70kDa proteins | Heat shock protein family A member 1B | 0.906 |
HSPA13 | HSPA1L | ENSP00000285667 | ENSP00000364805 | Heat shock 70 kDa protein 13; Has peptide-independent ATPase activity; Heat shock 70kDa proteins | Heat shock 70 kDa protein 1-like; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis an [...] | 0.910 |
HSPA13 | HSPA2 | ENSP00000285667 | ENSP00000378199 | Heat shock 70 kDa protein 13; Has peptide-independent ATPase activity; Heat shock 70kDa proteins | Heat shock-related 70 kDa protein 2; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis [...] | 0.906 |
HSPA13 | HSPA4 | ENSP00000285667 | ENSP00000302961 | Heat shock 70 kDa protein 13; Has peptide-independent ATPase activity; Heat shock 70kDa proteins | Heat shock protein family A member 4; Belongs to the heat shock protein 70 family | 0.938 |
HSPA13 | HSPA4L | ENSP00000285667 | ENSP00000296464 | Heat shock 70 kDa protein 13; Has peptide-independent ATPase activity; Heat shock 70kDa proteins | Heat shock 70 kDa protein 4L; Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase; Belongs to the heat shock protein 70 family | 0.937 |
HSPA13 | HSPA5 | ENSP00000285667 | ENSP00000324173 | Heat shock 70 kDa protein 13; Has peptide-independent ATPase activity; Heat shock 70kDa proteins | 78 kDa glucose-regulated protein; Plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate (By similarity); Belongs to the heat shock protein 70 family | 0.922 |
HSPA13 | HSPA8 | ENSP00000285667 | ENSP00000432083 | Heat shock 70 kDa protein 13; Has peptide-independent ATPase activity; Heat shock 70kDa proteins | Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...] | 0.911 |
HSPA13 | HSPA9 | ENSP00000285667 | ENSP00000297185 | Heat shock 70 kDa protein 13; Has peptide-independent ATPase activity; Heat shock 70kDa proteins | Stress-70 protein, mitochondrial; Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging (By similarity); Belongs to the heat shock protein 70 family | 0.924 |