node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BACH2 | C1QTNF6 | ENSP00000257749 | ENSP00000338812 | Transcription regulator protein BACH2; Transcriptional regulator that acts as repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1. Positively regulates the nuclear import of actin (By similarity); BTB domain containing | Complement C1q tumor necrosis factor-related protein 6; C1q and TNF related 6 | 0.487 |
BACH2 | CTSH | ENSP00000257749 | ENSP00000220166 | Transcription regulator protein BACH2; Transcriptional regulator that acts as repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1. Positively regulates the nuclear import of actin (By similarity); BTB domain containing | Pro-cathepsin H; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family | 0.470 |
BACH2 | NAA25 | ENSP00000257749 | ENSP00000261745 | Transcription regulator protein BACH2; Transcriptional regulator that acts as repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1. Positively regulates the nuclear import of actin (By similarity); BTB domain containing | N-alpha-acetyltransferase 25, NatB auxiliary subunit; Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp-Glu. May play a role in normal cell-cycle progression; Belongs to the MDM20/NAA25 family | 0.468 |
BACH2 | PTPN22 | ENSP00000257749 | ENSP00000352833 | Transcription regulator protein BACH2; Transcriptional regulator that acts as repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1. Positively regulates the nuclear import of actin (By similarity); BTB domain containing | Tyrosine-protein phosphatase non-receptor type 22; Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating ’Tyr-394’ residue. Dephosphorylates ZAP70 at its activating ’Tyr- 493’ residue. Dephosphorylates the immune system activator SKAP2. Positively regulates toll-like receptor (TLR)-induced type 1 interferon production. Promotes host [...] | 0.518 |
BACH2 | UBASH3A | ENSP00000257749 | ENSP00000317327 | Transcription regulator protein BACH2; Transcriptional regulator that acts as repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1. Positively regulates the nuclear import of actin (By similarity); BTB domain containing | Ubiquitin-associated and SH3 domain-containing protein A; Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain | 0.529 |
C1QTNF6 | BACH2 | ENSP00000338812 | ENSP00000257749 | Complement C1q tumor necrosis factor-related protein 6; C1q and TNF related 6 | Transcription regulator protein BACH2; Transcriptional regulator that acts as repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1. Positively regulates the nuclear import of actin (By similarity); BTB domain containing | 0.487 |
C1QTNF6 | CTSH | ENSP00000338812 | ENSP00000220166 | Complement C1q tumor necrosis factor-related protein 6; C1q and TNF related 6 | Pro-cathepsin H; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family | 0.527 |
C1QTNF6 | FAM83A | ENSP00000338812 | ENSP00000428876 | Complement C1q tumor necrosis factor-related protein 6; C1q and TNF related 6 | Protein FAM83A; Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both RAS/MAPK and PI3K/AKT/TOR signaling cascades downstream of EGFR. Required for the RAS/MAPK signaling cascade activation upon EGFR stimulation, it also activates both signaling cascades independently of EGFR activation; Belongs to the FAM83 family | 0.675 |
C1QTNF6 | IL10 | ENSP00000338812 | ENSP00000412237 | Complement C1q tumor necrosis factor-related protein 6; C1q and TNF related 6 | Interleukin-10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells; Belongs to the IL-10 family | 0.519 |
C1QTNF6 | KCTD17 | ENSP00000338812 | ENSP00000385096 | Complement C1q tumor necrosis factor-related protein 6; C1q and TNF related 6 | BTB/POZ domain-containing protein KCTD17; Is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. It acts as a substrate-adapter for CUL3-RING ubiquitin ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of TCHP, a protein involved in ciliogenesis down-regulation. May be involved in endoplasmic reticulum calcium ion homeostasis | 0.483 |
C1QTNF6 | NAA25 | ENSP00000338812 | ENSP00000261745 | Complement C1q tumor necrosis factor-related protein 6; C1q and TNF related 6 | N-alpha-acetyltransferase 25, NatB auxiliary subunit; Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp-Glu. May play a role in normal cell-cycle progression; Belongs to the MDM20/NAA25 family | 0.507 |
C1QTNF6 | PTPN22 | ENSP00000338812 | ENSP00000352833 | Complement C1q tumor necrosis factor-related protein 6; C1q and TNF related 6 | Tyrosine-protein phosphatase non-receptor type 22; Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating ’Tyr-394’ residue. Dephosphorylates ZAP70 at its activating ’Tyr- 493’ residue. Dephosphorylates the immune system activator SKAP2. Positively regulates toll-like receptor (TLR)-induced type 1 interferon production. Promotes host [...] | 0.558 |
C1QTNF6 | RERE | ENSP00000338812 | ENSP00000338629 | Complement C1q tumor necrosis factor-related protein 6; C1q and TNF related 6 | Arginine-glutamic acid dipeptide repeats protein; Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death; GATA zinc finger domain containing | 0.472 |
C1QTNF6 | UBASH3A | ENSP00000338812 | ENSP00000317327 | Complement C1q tumor necrosis factor-related protein 6; C1q and TNF related 6 | Ubiquitin-associated and SH3 domain-containing protein A; Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain | 0.587 |
C1QTNF6 | ZSCAN12 | ENSP00000338812 | ENSP00000354305 | Complement C1q tumor necrosis factor-related protein 6; C1q and TNF related 6 | Zinc finger and SCAN domain-containing protein 12; May be involved in transcriptional regulation; SCAN domain containing | 0.571 |
CTSH | BACH2 | ENSP00000220166 | ENSP00000257749 | Pro-cathepsin H; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family | Transcription regulator protein BACH2; Transcriptional regulator that acts as repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1. Positively regulates the nuclear import of actin (By similarity); BTB domain containing | 0.470 |
CTSH | C1QTNF6 | ENSP00000220166 | ENSP00000338812 | Pro-cathepsin H; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family | Complement C1q tumor necrosis factor-related protein 6; C1q and TNF related 6 | 0.527 |
CTSH | NAA25 | ENSP00000220166 | ENSP00000261745 | Pro-cathepsin H; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family | N-alpha-acetyltransferase 25, NatB auxiliary subunit; Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp-Glu. May play a role in normal cell-cycle progression; Belongs to the MDM20/NAA25 family | 0.501 |
FAM83A | C1QTNF6 | ENSP00000428876 | ENSP00000338812 | Protein FAM83A; Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both RAS/MAPK and PI3K/AKT/TOR signaling cascades downstream of EGFR. Required for the RAS/MAPK signaling cascade activation upon EGFR stimulation, it also activates both signaling cascades independently of EGFR activation; Belongs to the FAM83 family | Complement C1q tumor necrosis factor-related protein 6; C1q and TNF related 6 | 0.675 |
FAM83A | ZSCAN12 | ENSP00000428876 | ENSP00000354305 | Protein FAM83A; Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both RAS/MAPK and PI3K/AKT/TOR signaling cascades downstream of EGFR. Required for the RAS/MAPK signaling cascade activation upon EGFR stimulation, it also activates both signaling cascades independently of EGFR activation; Belongs to the FAM83 family | Zinc finger and SCAN domain-containing protein 12; May be involved in transcriptional regulation; SCAN domain containing | 0.600 |