• Version:
  • 11.0 [archived version]
STRINGSTRING
POLR1B POLR1B CST11 CST11 CST7 CST7 NXT1 NXT1 GZF1 GZF1 CSTL1 CSTL1 CST9L CST9L ACSS1 ACSS1 NXT2 NXT2 CST8 CST8 THNSL2 THNSL2
"GZF1" - GDNF-inducible zinc finger protein 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
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Textmining
[Homology]
Score
GZF1GDNF-inducible zinc finger protein 1; Transcriptional repressor. Binds the GZF1 responsive element (GRE) (consensus- 5’-TGCGCN[TG][CA]TATA-3’). May be regulating VSX2/HOX10 expression; Belongs to the krueppel C2H2-type zinc-finger protein family (711 aa)    
Predicted Functional Partners:
NXT1
NTF2-related export protein 1; Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 (140 aa)
           
  0.748
CST9L
Cystatin-9-like; Cystatins, type 2; Belongs to the cystatin family (147 aa)
           
  0.725
CSTL1
Cystatin-like 1; Cystatins, type 2 (145 aa)
           
  0.712
ACSS1
Acetyl-coenzyme A synthetase 2-like, mitochondrial; Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2); Belongs to the ATP-dependent AMP-binding enzyme family (689 aa)
     
 
  0.701
CST7
Cystatin-F; Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system; Cystatins, type 2 (145 aa)
           
  0.691
CST8
Cystatin-8; Performs a specialized role during sperm development and maturation; Cystatins, type 2 (142 aa)
           
  0.659
CST11
Cystatin-11; Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization; Belongs to the cystatin family (138 aa)
           
  0.652
POLR1B
DNA-directed RNA polymerase I subunit RPA2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity) (1173 aa)
       
 
  0.649
THNSL2
Threonine synthase-like 2; Isoform 1- Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho- threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate (By similarity) (484 aa)
           
  0.626
NXT2
NTF2-related export protein 2; Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export (197 aa)
           
  0.623
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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