node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACSS1 | CST11 | ENSP00000316924 | ENSP00000366208 | Acetyl-coenzyme A synthetase 2-like, mitochondrial; Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2); Belongs to the ATP-dependent AMP-binding enzyme family | Cystatin-11; Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization; Belongs to the cystatin family | 0.668 |
ACSS1 | CST7 | ENSP00000316924 | ENSP00000420384 | Acetyl-coenzyme A synthetase 2-like, mitochondrial; Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2); Belongs to the ATP-dependent AMP-binding enzyme family | Cystatin-F; Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system; Cystatins, type 2 | 0.660 |
ACSS1 | CST8 | ENSP00000316924 | ENSP00000246012 | Acetyl-coenzyme A synthetase 2-like, mitochondrial; Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2); Belongs to the ATP-dependent AMP-binding enzyme family | Cystatin-8; Performs a specialized role during sperm development and maturation; Cystatins, type 2 | 0.634 |
ACSS1 | CST9L | ENSP00000316924 | ENSP00000366178 | Acetyl-coenzyme A synthetase 2-like, mitochondrial; Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2); Belongs to the ATP-dependent AMP-binding enzyme family | Cystatin-9-like; Cystatins, type 2; Belongs to the cystatin family | 0.586 |
ACSS1 | CSTL1 | ENSP00000316924 | ENSP00000344907 | Acetyl-coenzyme A synthetase 2-like, mitochondrial; Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2); Belongs to the ATP-dependent AMP-binding enzyme family | Cystatin-like 1; Cystatins, type 2 | 0.705 |
ACSS1 | GZF1 | ENSP00000316924 | ENSP00000338290 | Acetyl-coenzyme A synthetase 2-like, mitochondrial; Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2); Belongs to the ATP-dependent AMP-binding enzyme family | GDNF-inducible zinc finger protein 1; Transcriptional repressor. Binds the GZF1 responsive element (GRE) (consensus- 5’-TGCGCN[TG][CA]TATA-3’). May be regulating VSX2/HOX10 expression; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.701 |
ACSS1 | NXT1 | ENSP00000316924 | ENSP00000254998 | Acetyl-coenzyme A synthetase 2-like, mitochondrial; Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2); Belongs to the ATP-dependent AMP-binding enzyme family | NTF2-related export protein 1; Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 | 0.653 |
ACSS1 | NXT2 | ENSP00000316924 | ENSP00000218004 | Acetyl-coenzyme A synthetase 2-like, mitochondrial; Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2); Belongs to the ATP-dependent AMP-binding enzyme family | NTF2-related export protein 2; Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export | 0.623 |
CST11 | ACSS1 | ENSP00000366208 | ENSP00000316924 | Cystatin-11; Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization; Belongs to the cystatin family | Acetyl-coenzyme A synthetase 2-like, mitochondrial; Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2); Belongs to the ATP-dependent AMP-binding enzyme family | 0.668 |
CST11 | CST7 | ENSP00000366208 | ENSP00000420384 | Cystatin-11; Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization; Belongs to the cystatin family | Cystatin-F; Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system; Cystatins, type 2 | 0.685 |
CST11 | GZF1 | ENSP00000366208 | ENSP00000338290 | Cystatin-11; Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization; Belongs to the cystatin family | GDNF-inducible zinc finger protein 1; Transcriptional repressor. Binds the GZF1 responsive element (GRE) (consensus- 5’-TGCGCN[TG][CA]TATA-3’). May be regulating VSX2/HOX10 expression; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.652 |
CST11 | NXT1 | ENSP00000366208 | ENSP00000254998 | Cystatin-11; Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization; Belongs to the cystatin family | NTF2-related export protein 1; Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 | 0.834 |
CST11 | NXT2 | ENSP00000366208 | ENSP00000218004 | Cystatin-11; Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization; Belongs to the cystatin family | NTF2-related export protein 2; Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export | 0.447 |
CST7 | ACSS1 | ENSP00000420384 | ENSP00000316924 | Cystatin-F; Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system; Cystatins, type 2 | Acetyl-coenzyme A synthetase 2-like, mitochondrial; Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2); Belongs to the ATP-dependent AMP-binding enzyme family | 0.660 |
CST7 | CST11 | ENSP00000420384 | ENSP00000366208 | Cystatin-F; Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system; Cystatins, type 2 | Cystatin-11; Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization; Belongs to the cystatin family | 0.685 |
CST7 | CST9L | ENSP00000420384 | ENSP00000366178 | Cystatin-F; Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system; Cystatins, type 2 | Cystatin-9-like; Cystatins, type 2; Belongs to the cystatin family | 0.768 |
CST7 | GZF1 | ENSP00000420384 | ENSP00000338290 | Cystatin-F; Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system; Cystatins, type 2 | GDNF-inducible zinc finger protein 1; Transcriptional repressor. Binds the GZF1 responsive element (GRE) (consensus- 5’-TGCGCN[TG][CA]TATA-3’). May be regulating VSX2/HOX10 expression; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.691 |
CST7 | NXT1 | ENSP00000420384 | ENSP00000254998 | Cystatin-F; Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system; Cystatins, type 2 | NTF2-related export protein 1; Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 | 0.659 |
CST7 | NXT2 | ENSP00000420384 | ENSP00000218004 | Cystatin-F; Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system; Cystatins, type 2 | NTF2-related export protein 2; Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export | 0.623 |
CST8 | ACSS1 | ENSP00000246012 | ENSP00000316924 | Cystatin-8; Performs a specialized role during sperm development and maturation; Cystatins, type 2 | Acetyl-coenzyme A synthetase 2-like, mitochondrial; Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2); Belongs to the ATP-dependent AMP-binding enzyme family | 0.634 |