node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KDM5C | ZMYND8 | ENSP00000364550 | ENSP00000420095 | Lysine-specific demethylase 5C; Histone demethylase that specifically demethylates ’Lys- 4’ of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ’Lys-9’, H3 ’Lys-27’, H3 ’Lys-36’, H3 ’Lys-79’ or H4 ’Lys-20’. Demethylates trimethylated and dimethylated but not monomethylated H3 ’Lys-4’. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer- mediated transcriptional activation of the core clock component PER2 (By [...] | Protein kinase C-binding protein 1; May act as a transcriptional corepressor for KDM5D. Required for KDM5D-mediated down-regulation of diverse metastasis- associated genes; the function seems to involve the recognition of the dual histone signature H3K4me1-H3K14ac. Suppresses prostate cancer cell invasion; Bromodomain containing | 0.698 |
KDM5C | ZNF532 | ENSP00000364550 | ENSP00000338217 | Lysine-specific demethylase 5C; Histone demethylase that specifically demethylates ’Lys- 4’ of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ’Lys-9’, H3 ’Lys-27’, H3 ’Lys-36’, H3 ’Lys-79’ or H4 ’Lys-20’. Demethylates trimethylated and dimethylated but not monomethylated H3 ’Lys-4’. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer- mediated transcriptional activation of the core clock component PER2 (By [...] | Zinc finger protein 532; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.693 |
MXD1 | PKN2 | ENSP00000264444 | ENSP00000359552 | Max dimerization protein 1; Transcriptional repressor. MAD binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5’-CAC[GA]TG-3’. MAD thus antagonizes MYC transcriptional activity by competing for MAX; Basic helix-loop-helix proteins | Serine/threonine-protein kinase N2; PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the re [...] | 0.537 |
MXD1 | ST8SIA2 | ENSP00000264444 | ENSP00000268164 | Max dimerization protein 1; Transcriptional repressor. MAD binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5’-CAC[GA]TG-3’. MAD thus antagonizes MYC transcriptional activity by competing for MAX; Basic helix-loop-helix proteins | Alpha-2,8-sialyltransferase 8B; May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression; Belongs to the glycosyltransferase 29 family | 0.629 |
MXD1 | ZNF532 | ENSP00000264444 | ENSP00000338217 | Max dimerization protein 1; Transcriptional repressor. MAD binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5’-CAC[GA]TG-3’. MAD thus antagonizes MYC transcriptional activity by competing for MAX; Basic helix-loop-helix proteins | Zinc finger protein 532; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.679 |
PKN2 | MXD1 | ENSP00000359552 | ENSP00000264444 | Serine/threonine-protein kinase N2; PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the re [...] | Max dimerization protein 1; Transcriptional repressor. MAD binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5’-CAC[GA]TG-3’. MAD thus antagonizes MYC transcriptional activity by competing for MAX; Basic helix-loop-helix proteins | 0.537 |
PKN2 | ST8SIA2 | ENSP00000359552 | ENSP00000268164 | Serine/threonine-protein kinase N2; PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the re [...] | Alpha-2,8-sialyltransferase 8B; May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression; Belongs to the glycosyltransferase 29 family | 0.541 |
PKN2 | ZNF532 | ENSP00000359552 | ENSP00000338217 | Serine/threonine-protein kinase N2; PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the re [...] | Zinc finger protein 532; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.601 |
ST8SIA2 | MXD1 | ENSP00000268164 | ENSP00000264444 | Alpha-2,8-sialyltransferase 8B; May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression; Belongs to the glycosyltransferase 29 family | Max dimerization protein 1; Transcriptional repressor. MAD binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5’-CAC[GA]TG-3’. MAD thus antagonizes MYC transcriptional activity by competing for MAX; Basic helix-loop-helix proteins | 0.629 |
ST8SIA2 | PKN2 | ENSP00000268164 | ENSP00000359552 | Alpha-2,8-sialyltransferase 8B; May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression; Belongs to the glycosyltransferase 29 family | Serine/threonine-protein kinase N2; PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the re [...] | 0.541 |
ST8SIA2 | ZNF532 | ENSP00000268164 | ENSP00000338217 | Alpha-2,8-sialyltransferase 8B; May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression; Belongs to the glycosyltransferase 29 family | Zinc finger protein 532; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.656 |
TRMT13 | ZNF532 | ENSP00000359160 | ENSP00000338217 | tRNA-m(4)X modification enzyme TRM13 homolog; tRNA methylase which 2’-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His) | Zinc finger protein 532; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.628 |
ZBTB21 | ZNF22 | ENSP00000308759 | ENSP00000298299 | Zinc finger and BTB domain-containing protein 21; Acts as a transcription repressor; BTB domain containing | Zinc finger protein 22; Binds DNA through the consensus sequence 5’-CAATG-3’. May be involved in transcriptional regulation and may play a role in tooth formation (By similarity); Zinc fingers C2H2-type | 0.587 |
ZBTB21 | ZNF532 | ENSP00000308759 | ENSP00000338217 | Zinc finger and BTB domain-containing protein 21; Acts as a transcription repressor; BTB domain containing | Zinc finger protein 532; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.719 |
ZBTB21 | ZNF608 | ENSP00000308759 | ENSP00000307746 | Zinc finger and BTB domain-containing protein 21; Acts as a transcription repressor; BTB domain containing | Zinc finger protein 608; Transcription factor, which represses ZNF609 transcription; Zinc fingers C2H2-type | 0.638 |
ZBTB38 | ZNF532 | ENSP00000426387 | ENSP00000338217 | Zinc finger and BTB domain-containing protein 38; Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5’-CGCG-3’ but can also bind to E-box elements (5’-CACGTG-3’). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl- CpG-dependent manner. Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA- replicatio [...] | Zinc finger protein 532; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.594 |
ZBTB38 | ZNF608 | ENSP00000426387 | ENSP00000307746 | Zinc finger and BTB domain-containing protein 38; Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5’-CGCG-3’ but can also bind to E-box elements (5’-CACGTG-3’). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl- CpG-dependent manner. Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA- replicatio [...] | Zinc finger protein 608; Transcription factor, which represses ZNF609 transcription; Zinc fingers C2H2-type | 0.494 |
ZMYND8 | KDM5C | ENSP00000420095 | ENSP00000364550 | Protein kinase C-binding protein 1; May act as a transcriptional corepressor for KDM5D. Required for KDM5D-mediated down-regulation of diverse metastasis- associated genes; the function seems to involve the recognition of the dual histone signature H3K4me1-H3K14ac. Suppresses prostate cancer cell invasion; Bromodomain containing | Lysine-specific demethylase 5C; Histone demethylase that specifically demethylates ’Lys- 4’ of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ’Lys-9’, H3 ’Lys-27’, H3 ’Lys-36’, H3 ’Lys-79’ or H4 ’Lys-20’. Demethylates trimethylated and dimethylated but not monomethylated H3 ’Lys-4’. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer- mediated transcriptional activation of the core clock component PER2 (By [...] | 0.698 |
ZMYND8 | ZNF532 | ENSP00000420095 | ENSP00000338217 | Protein kinase C-binding protein 1; May act as a transcriptional corepressor for KDM5D. Required for KDM5D-mediated down-regulation of diverse metastasis- associated genes; the function seems to involve the recognition of the dual histone signature H3K4me1-H3K14ac. Suppresses prostate cancer cell invasion; Bromodomain containing | Zinc finger protein 532; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.698 |
ZNF22 | ZBTB21 | ENSP00000298299 | ENSP00000308759 | Zinc finger protein 22; Binds DNA through the consensus sequence 5’-CAATG-3’. May be involved in transcriptional regulation and may play a role in tooth formation (By similarity); Zinc fingers C2H2-type | Zinc finger and BTB domain-containing protein 21; Acts as a transcription repressor; BTB domain containing | 0.587 |