TMEM39B protein (human) - STRING database

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TMEM39B

Transmembrane protein 39B; Belongs to the TMEM39 family (492 aa)

Predicted Functional Partners:

RHBDD3

0.681

FAM118A

0.598

DNAJC18

0.596

LETM2

0.573

PLD6

0.560

GPAT2

0.490

REEP6

0.475

GSG1

0.473

KCNK12

0.473

BBS9

0.453

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BBS9	RHBDD3	ENSP00000242067	ENSP00000216085	Protein PTHB1; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF [...]	Rhomboid domain containing 3	0.434
BBS9	TMEM39B	ENSP00000242067	ENSP00000338165	Protein PTHB1; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF [...]	Transmembrane protein 39B; Belongs to the TMEM39 family	0.453
DNAJC18	FAM118A	ENSP00000302843	ENSP00000216214	DnaJ heat shock protein family member C18	Protein FAM118A; Family with sequence similarity 118 member A	0.515
DNAJC18	GPAT2	ENSP00000302843	ENSP00000389395	DnaJ heat shock protein family member C18	Glycerol-3-phosphate acyltransferase 2, mitochondrial; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Required for primary processing step during piRNA biosynthesis. Molecular mechanisms by which it promotes piRNA biosynthesis are unclear and do not involve its acyltransferase activity; Belongs to the GPAT/DAPAT family	0.403
DNAJC18	LETM2	ENSP00000302843	ENSP00000369291	DnaJ heat shock protein family member C18	LETM1 domain-containing protein LETM2, mitochondrial; Leucine zipper and EF-hand containing transmembrane protein 2	0.478
DNAJC18	PLD6	ENSP00000302843	ENSP00000317177	DnaJ heat shock protein family member C18	Mitochondrial cardiolipin hydrolase; Endonuclease that plays a critical role in PIWI- interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements (By similarity). piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation (By similarity). Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface (By similarity). A [...]	0.408
DNAJC18	RHBDD3	ENSP00000302843	ENSP00000216085	DnaJ heat shock protein family member C18	Rhomboid domain containing 3	0.538
DNAJC18	TMEM39B	ENSP00000302843	ENSP00000338165	DnaJ heat shock protein family member C18	Transmembrane protein 39B; Belongs to the TMEM39 family	0.596
FAM118A	DNAJC18	ENSP00000216214	ENSP00000302843	Protein FAM118A; Family with sequence similarity 118 member A	DnaJ heat shock protein family member C18	0.515
FAM118A	GPAT2	ENSP00000216214	ENSP00000389395	Protein FAM118A; Family with sequence similarity 118 member A	Glycerol-3-phosphate acyltransferase 2, mitochondrial; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Required for primary processing step during piRNA biosynthesis. Molecular mechanisms by which it promotes piRNA biosynthesis are unclear and do not involve its acyltransferase activity; Belongs to the GPAT/DAPAT family	0.406
FAM118A	LETM2	ENSP00000216214	ENSP00000369291	Protein FAM118A; Family with sequence similarity 118 member A	LETM1 domain-containing protein LETM2, mitochondrial; Leucine zipper and EF-hand containing transmembrane protein 2	0.488
FAM118A	PLD6	ENSP00000216214	ENSP00000317177	Protein FAM118A; Family with sequence similarity 118 member A	Mitochondrial cardiolipin hydrolase; Endonuclease that plays a critical role in PIWI- interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements (By similarity). piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation (By similarity). Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface (By similarity). A [...]	0.422
FAM118A	RHBDD3	ENSP00000216214	ENSP00000216085	Protein FAM118A; Family with sequence similarity 118 member A	Rhomboid domain containing 3	0.541
FAM118A	TMEM39B	ENSP00000216214	ENSP00000338165	Protein FAM118A; Family with sequence similarity 118 member A	Transmembrane protein 39B; Belongs to the TMEM39 family	0.598
GPAT2	DNAJC18	ENSP00000389395	ENSP00000302843	Glycerol-3-phosphate acyltransferase 2, mitochondrial; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Required for primary processing step during piRNA biosynthesis. Molecular mechanisms by which it promotes piRNA biosynthesis are unclear and do not involve its acyltransferase activity; Belongs to the GPAT/DAPAT family	DnaJ heat shock protein family member C18	0.403
GPAT2	FAM118A	ENSP00000389395	ENSP00000216214	Glycerol-3-phosphate acyltransferase 2, mitochondrial; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Required for primary processing step during piRNA biosynthesis. Molecular mechanisms by which it promotes piRNA biosynthesis are unclear and do not involve its acyltransferase activity; Belongs to the GPAT/DAPAT family	Protein FAM118A; Family with sequence similarity 118 member A	0.406
GPAT2	PLD6	ENSP00000389395	ENSP00000317177	Glycerol-3-phosphate acyltransferase 2, mitochondrial; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Required for primary processing step during piRNA biosynthesis. Molecular mechanisms by which it promotes piRNA biosynthesis are unclear and do not involve its acyltransferase activity; Belongs to the GPAT/DAPAT family	Mitochondrial cardiolipin hydrolase; Endonuclease that plays a critical role in PIWI- interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements (By similarity). piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation (By similarity). Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface (By similarity). A [...]	0.466
GPAT2	RHBDD3	ENSP00000389395	ENSP00000216085	Glycerol-3-phosphate acyltransferase 2, mitochondrial; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Required for primary processing step during piRNA biosynthesis. Molecular mechanisms by which it promotes piRNA biosynthesis are unclear and do not involve its acyltransferase activity; Belongs to the GPAT/DAPAT family	Rhomboid domain containing 3	0.425
GPAT2	TMEM39B	ENSP00000389395	ENSP00000338165	Glycerol-3-phosphate acyltransferase 2, mitochondrial; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Required for primary processing step during piRNA biosynthesis. Molecular mechanisms by which it promotes piRNA biosynthesis are unclear and do not involve its acyltransferase activity; Belongs to the GPAT/DAPAT family	Transmembrane protein 39B; Belongs to the TMEM39 family	0.490
GSG1	TMEM39B	ENSP00000405032	ENSP00000338165	Germ cell-specific gene 1 protein; May cause the redistribution of PAPOLB from the cytosol to the endoplasmic reticulum	Transmembrane protein 39B; Belongs to the TMEM39 family	0.473

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