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  • 11.0 [archived version]
STRINGSTRING
NR2F6 NR2F6 MYH3 MYH3 RBM24 RBM24 DNAJC14 DNAJC14 CDK5RAP2 CDK5RAP2 NCKAP5L NCKAP5L TEX2 TEX2 C2orf15 C2orf15 CLTCL1 CLTCL1 UBE3B UBE3B ZNF18 ZNF18
"NCKAP5L" - Nck-associated protein 5-like in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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NCKAP5LNck-associated protein 5-like; Regulates microtubule organization and stabilization. Promotes microtubule growth and bundling formation and stabilizes microtubules by increasing intense acetylation of microtubules. Both tubulin-binding and homodimer formation are required for NCKAP5L-mediated microtubule bundle formation (1334 aa)    
Predicted Functional Partners:
ZNF18
Zinc finger protein 18; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family (549 aa)
           
  0.740
TEX2
Testis-expressed protein 2; Testis expressed 2 (1134 aa)
           
  0.714
CDK5RAP2
CDK5 regulatory subunit-associated protein 2; Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with MAPRE1, it may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Regulates centrosomal maturation by recruitment of [...] (1893 aa)
           
  0.696
MYH3
Myosin-3; Muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family (1940 aa)
           
  0.668
C2orf15
Uncharacterized protein C2orf15; Chromosome 2 open reading frame 15 (125 aa)
           
  0.642
NR2F6
Nuclear receptor subfamily 2 group F member 6; Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5’-AGGTCA-3’ direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcription [...] (404 aa)
           
  0.628
DNAJC14
DnaJ homolog subfamily C member 14; Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface; DNAJ heat shock proteins (702 aa)
           
  0.618
RBM24
RNA-binding protein 24; Plays a role in myogenic differentiation by regulating MYOG levels. Binds to the 3’-UTR of MYOG mRNA and regulates its stability; RNA binding motif containing (236 aa)
           
  0.590
CLTCL1
Clathrin heavy chain 2; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity) (1640 aa)
           
  0.588
UBE3B
Ubiquitin-protein ligase E3B; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (1068 aa)
           
  0.587
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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