HEXDC protein (human) - STRING database

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Score

HEXDC

Hexosaminidase D; Has hexosaminidase activity; Belongs to the glycosyl hydrolase 20 family (585 aa)

Predicted Functional Partners:

HEXA

0.940

HEXB

0.919

YPEL5

0.697

MGEA5

0.672

ZNF662

0.602

FAM198A

0.580

ARMC7

0.565

KIN

0.516

GANC

0.514

INTS2

0.509

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARMC7	FAM198A	ENSP00000245543	ENSP00000407301	Armadillo repeat containing 7	Protein FAM198A; Family with sequence similarity 198 member A; Belongs to the FAM198 family	0.622
ARMC7	HEXDC	ENSP00000245543	ENSP00000337854	Armadillo repeat containing 7	Hexosaminidase D; Has hexosaminidase activity; Belongs to the glycosyl hydrolase 20 family	0.565
ARMC7	INTS2	ENSP00000245543	ENSP00000414237	Armadillo repeat containing 7	Integrator complex subunit 2; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3’-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex	0.539
ARMC7	ZNF662	ENSP00000245543	ENSP00000329264	Armadillo repeat containing 7	Zinc finger protein 662; Zinc fingers C2H2-type	0.650
FAM198A	ARMC7	ENSP00000407301	ENSP00000245543	Protein FAM198A; Family with sequence similarity 198 member A; Belongs to the FAM198 family	Armadillo repeat containing 7	0.622
FAM198A	HEXDC	ENSP00000407301	ENSP00000337854	Protein FAM198A; Family with sequence similarity 198 member A; Belongs to the FAM198 family	Hexosaminidase D; Has hexosaminidase activity; Belongs to the glycosyl hydrolase 20 family	0.580
FAM198A	ZNF662	ENSP00000407301	ENSP00000329264	Protein FAM198A; Family with sequence similarity 198 member A; Belongs to the FAM198 family	Zinc finger protein 662; Zinc fingers C2H2-type	0.663
GANC	HEXDC	ENSP00000326227	ENSP00000337854	Neutral alpha-glucosidase C; Has alpha-glucosidase activity	Hexosaminidase D; Has hexosaminidase activity; Belongs to the glycosyl hydrolase 20 family	0.514
GANC	MGEA5	ENSP00000326227	ENSP00000354850	Neutral alpha-glucosidase C; Has alpha-glucosidase activity	Protein O-GlcNAcase; Isoform 1- Cleaves GlcNAc but not GalNAc from O- glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4- methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl- beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro). Does not bind acetyl-CoA and does not have histone acetyltransferase activity; Belongs to the glycosyl hydrolase 84 family	0.658
HEXA	HEXB	ENSP00000268097	ENSP00000261416	Beta-hexosaminidase subunit alpha; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. The form B is active against certain oligosaccharides. The form S has no measurable activity; Belongs to the glycosyl hydrolase 20 family	Beta-hexosaminidase subunit beta; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues; Belongs to the glycosyl hydrolase 20 family	0.994
HEXA	HEXDC	ENSP00000268097	ENSP00000337854	Beta-hexosaminidase subunit alpha; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. The form B is active against certain oligosaccharides. The form S has no measurable activity; Belongs to the glycosyl hydrolase 20 family	Hexosaminidase D; Has hexosaminidase activity; Belongs to the glycosyl hydrolase 20 family	0.940
HEXA	MGEA5	ENSP00000268097	ENSP00000354850	Beta-hexosaminidase subunit alpha; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. The form B is active against certain oligosaccharides. The form S has no measurable activity; Belongs to the glycosyl hydrolase 20 family	Protein O-GlcNAcase; Isoform 1- Cleaves GlcNAc but not GalNAc from O- glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4- methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl- beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro). Does not bind acetyl-CoA and does not have histone acetyltransferase activity; Belongs to the glycosyl hydrolase 84 family	0.844
HEXB	HEXA	ENSP00000261416	ENSP00000268097	Beta-hexosaminidase subunit beta; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues; Belongs to the glycosyl hydrolase 20 family	Beta-hexosaminidase subunit alpha; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. The form B is active against certain oligosaccharides. The form S has no measurable activity; Belongs to the glycosyl hydrolase 20 family	0.994
HEXB	HEXDC	ENSP00000261416	ENSP00000337854	Beta-hexosaminidase subunit beta; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues; Belongs to the glycosyl hydrolase 20 family	Hexosaminidase D; Has hexosaminidase activity; Belongs to the glycosyl hydrolase 20 family	0.919
HEXB	MGEA5	ENSP00000261416	ENSP00000354850	Beta-hexosaminidase subunit beta; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues; Belongs to the glycosyl hydrolase 20 family	Protein O-GlcNAcase; Isoform 1- Cleaves GlcNAc but not GalNAc from O- glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4- methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl- beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro). Does not bind acetyl-CoA and does not have histone acetyltransferase activity; Belongs to the glycosyl hydrolase 84 family	0.662
HEXDC	ARMC7	ENSP00000337854	ENSP00000245543	Hexosaminidase D; Has hexosaminidase activity; Belongs to the glycosyl hydrolase 20 family	Armadillo repeat containing 7	0.565
HEXDC	FAM198A	ENSP00000337854	ENSP00000407301	Hexosaminidase D; Has hexosaminidase activity; Belongs to the glycosyl hydrolase 20 family	Protein FAM198A; Family with sequence similarity 198 member A; Belongs to the FAM198 family	0.580
HEXDC	GANC	ENSP00000337854	ENSP00000326227	Hexosaminidase D; Has hexosaminidase activity; Belongs to the glycosyl hydrolase 20 family	Neutral alpha-glucosidase C; Has alpha-glucosidase activity	0.514
HEXDC	HEXA	ENSP00000337854	ENSP00000268097	Hexosaminidase D; Has hexosaminidase activity; Belongs to the glycosyl hydrolase 20 family	Beta-hexosaminidase subunit alpha; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. The form B is active against certain oligosaccharides. The form S has no measurable activity; Belongs to the glycosyl hydrolase 20 family	0.940
HEXDC	HEXB	ENSP00000337854	ENSP00000261416	Hexosaminidase D; Has hexosaminidase activity; Belongs to the glycosyl hydrolase 20 family	Beta-hexosaminidase subunit beta; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues; Belongs to the glycosyl hydrolase 20 family	0.919

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