| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABCB1 | ABCB4 | ENSP00000478255 | ENSP00000265723 | Multidrug resistance protein 1; Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells; ATP binding cassette subfamily B | Phosphatidylcholine translocator ABCB4; Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts. Plays a role in the recruitment of pho [...] | 0.820 |
| ABCB1 | DMTF1 | ENSP00000478255 | ENSP00000378193 | Multidrug resistance protein 1; Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells; ATP binding cassette subfamily B | Cyclin-D-binding Myb-like transcription factor 1; Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest (By similarity). Binds to the consensus sequence 5’-CCCG[GT]ATGT-3’ (By similarity). Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1; Myb/SANT domain containing | 0.706 |
| ABCB1 | RUNDC3B | ENSP00000478255 | ENSP00000337732 | Multidrug resistance protein 1; Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells; ATP binding cassette subfamily B | RUN domain containing 3B | 0.663 |
| ABCB1 | SLC25A40 | ENSP00000478255 | ENSP00000344831 | Multidrug resistance protein 1; Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells; ATP binding cassette subfamily B | Solute carrier family 25 member 40 | 0.408 |
| ABCB4 | ABCB1 | ENSP00000265723 | ENSP00000478255 | Phosphatidylcholine translocator ABCB4; Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts. Plays a role in the recruitment of pho [...] | Multidrug resistance protein 1; Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells; ATP binding cassette subfamily B | 0.820 |
| ABCB4 | RUNDC3B | ENSP00000265723 | ENSP00000337732 | Phosphatidylcholine translocator ABCB4; Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts. Plays a role in the recruitment of pho [...] | RUN domain containing 3B | 0.569 |
| ABCB4 | TMEM243 | ENSP00000265723 | ENSP00000398083 | Phosphatidylcholine translocator ABCB4; Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts. Plays a role in the recruitment of pho [...] | Transmembrane protein 243; Belongs to the TMEM243 family | 0.426 |
| CROT | DMTF1 | ENSP00000413575 | ENSP00000378193 | Peroxisomal carnitine O-octanoyltransferase; Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl- CoA, to its corresponding carnitine ester; Belongs to the carnitine/choline acetyltransferase family | Cyclin-D-binding Myb-like transcription factor 1; Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest (By similarity). Binds to the consensus sequence 5’-CCCG[GT]ATGT-3’ (By similarity). Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1; Myb/SANT domain containing | 0.413 |
| CROT | RUNDC3B | ENSP00000413575 | ENSP00000337732 | Peroxisomal carnitine O-octanoyltransferase; Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl- CoA, to its corresponding carnitine ester; Belongs to the carnitine/choline acetyltransferase family | RUN domain containing 3B | 0.765 |
| CROT | SLC25A40 | ENSP00000413575 | ENSP00000344831 | Peroxisomal carnitine O-octanoyltransferase; Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl- CoA, to its corresponding carnitine ester; Belongs to the carnitine/choline acetyltransferase family | Solute carrier family 25 member 40 | 0.593 |
| CROT | TMEM243 | ENSP00000413575 | ENSP00000398083 | Peroxisomal carnitine O-octanoyltransferase; Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl- CoA, to its corresponding carnitine ester; Belongs to the carnitine/choline acetyltransferase family | Transmembrane protein 243; Belongs to the TMEM243 family | 0.474 |
| DBF4 | DMTF1 | ENSP00000265728 | ENSP00000378193 | Protein DBF4 homolog A; Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at ’Ser-40’ and ’Ser-53’ and then is involved in regulating the initiation of DNA replication during cell cycle; Zinc fingers DBF-type | Cyclin-D-binding Myb-like transcription factor 1; Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest (By similarity). Binds to the consensus sequence 5’-CCCG[GT]ATGT-3’ (By similarity). Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1; Myb/SANT domain containing | 0.432 |
| DBF4 | RUNDC3B | ENSP00000265728 | ENSP00000337732 | Protein DBF4 homolog A; Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at ’Ser-40’ and ’Ser-53’ and then is involved in regulating the initiation of DNA replication during cell cycle; Zinc fingers DBF-type | RUN domain containing 3B | 0.614 |
| DBF4 | SLC25A40 | ENSP00000265728 | ENSP00000344831 | Protein DBF4 homolog A; Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at ’Ser-40’ and ’Ser-53’ and then is involved in regulating the initiation of DNA replication during cell cycle; Zinc fingers DBF-type | Solute carrier family 25 member 40 | 0.511 |
| DBF4 | TMEM243 | ENSP00000265728 | ENSP00000398083 | Protein DBF4 homolog A; Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at ’Ser-40’ and ’Ser-53’ and then is involved in regulating the initiation of DNA replication during cell cycle; Zinc fingers DBF-type | Transmembrane protein 243; Belongs to the TMEM243 family | 0.485 |
| DMTF1 | ABCB1 | ENSP00000378193 | ENSP00000478255 | Cyclin-D-binding Myb-like transcription factor 1; Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest (By similarity). Binds to the consensus sequence 5’-CCCG[GT]ATGT-3’ (By similarity). Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1; Myb/SANT domain containing | Multidrug resistance protein 1; Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells; ATP binding cassette subfamily B | 0.706 |
| DMTF1 | CROT | ENSP00000378193 | ENSP00000413575 | Cyclin-D-binding Myb-like transcription factor 1; Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest (By similarity). Binds to the consensus sequence 5’-CCCG[GT]ATGT-3’ (By similarity). Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1; Myb/SANT domain containing | Peroxisomal carnitine O-octanoyltransferase; Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl- CoA, to its corresponding carnitine ester; Belongs to the carnitine/choline acetyltransferase family | 0.413 |
| DMTF1 | DBF4 | ENSP00000378193 | ENSP00000265728 | Cyclin-D-binding Myb-like transcription factor 1; Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest (By similarity). Binds to the consensus sequence 5’-CCCG[GT]ATGT-3’ (By similarity). Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1; Myb/SANT domain containing | Protein DBF4 homolog A; Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at ’Ser-40’ and ’Ser-53’ and then is involved in regulating the initiation of DNA replication during cell cycle; Zinc fingers DBF-type | 0.432 |
| DMTF1 | RUNDC3B | ENSP00000378193 | ENSP00000337732 | Cyclin-D-binding Myb-like transcription factor 1; Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest (By similarity). Binds to the consensus sequence 5’-CCCG[GT]ATGT-3’ (By similarity). Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1; Myb/SANT domain containing | RUN domain containing 3B | 0.713 |
| DMTF1 | SLC25A40 | ENSP00000378193 | ENSP00000344831 | Cyclin-D-binding Myb-like transcription factor 1; Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest (By similarity). Binds to the consensus sequence 5’-CCCG[GT]ATGT-3’ (By similarity). Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1; Myb/SANT domain containing | Solute carrier family 25 member 40 | 0.475 |
