node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CLIC1 | CLIC2 | ENSP00000364935 | ENSP00000358460 | Chloride intracellular channel protein 1; Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle | Chloride intracellular channel protein 2; Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx | 0.568 |
CLIC1 | CLIC3 | ENSP00000364935 | ENSP00000419378 | Chloride intracellular channel protein 1; Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle | Chloride intracellular channel protein 3; Can insert into membranes and form chloride ion channels. May participate in cellular growth control; Belongs to the chloride channel CLIC family | 0.565 |
CLIC1 | MAPK15 | ENSP00000364935 | ENSP00000337691 | Chloride intracellular channel protein 1; Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle | Mitogen-activated protein kinase 15; In vitro, phosphorylates MBP; Mitogen-activated protein kinases | 0.716 |
CLIC2 | CLIC1 | ENSP00000358460 | ENSP00000364935 | Chloride intracellular channel protein 2; Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx | Chloride intracellular channel protein 1; Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle | 0.568 |
CLIC2 | CLIC3 | ENSP00000358460 | ENSP00000419378 | Chloride intracellular channel protein 2; Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx | Chloride intracellular channel protein 3; Can insert into membranes and form chloride ion channels. May participate in cellular growth control; Belongs to the chloride channel CLIC family | 0.566 |
CLIC2 | MAPK15 | ENSP00000358460 | ENSP00000337691 | Chloride intracellular channel protein 2; Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx | Mitogen-activated protein kinase 15; In vitro, phosphorylates MBP; Mitogen-activated protein kinases | 0.800 |
CLIC3 | CLIC1 | ENSP00000419378 | ENSP00000364935 | Chloride intracellular channel protein 3; Can insert into membranes and form chloride ion channels. May participate in cellular growth control; Belongs to the chloride channel CLIC family | Chloride intracellular channel protein 1; Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle | 0.565 |
CLIC3 | CLIC2 | ENSP00000419378 | ENSP00000358460 | Chloride intracellular channel protein 3; Can insert into membranes and form chloride ion channels. May participate in cellular growth control; Belongs to the chloride channel CLIC family | Chloride intracellular channel protein 2; Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx | 0.566 |
CLIC3 | MAPK15 | ENSP00000419378 | ENSP00000337691 | Chloride intracellular channel protein 3; Can insert into membranes and form chloride ion channels. May participate in cellular growth control; Belongs to the chloride channel CLIC family | Mitogen-activated protein kinase 15; In vitro, phosphorylates MBP; Mitogen-activated protein kinases | 0.939 |
GIT1 | MAPK15 | ENSP00000378338 | ENSP00000337691 | ARF GTPase-activating protein GIT1; GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine- phosphorylated paxillin in cytoplasmic complexes. Involved in the regulation of cytokinesis; the function may involve SDCCAG3 and [...] | Mitogen-activated protein kinase 15; In vitro, phosphorylates MBP; Mitogen-activated protein kinases | 0.646 |
GIT1 | RFX2 | ENSP00000378338 | ENSP00000306335 | ARF GTPase-activating protein GIT1; GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine- phosphorylated paxillin in cytoplasmic complexes. Involved in the regulation of cytokinesis; the function may involve SDCCAG3 and [...] | DNA-binding protein RFX2; Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function (By similarity). Recognizes and binds the X-box, a regulatory motif with DNA sequence 5’-GTNRCC(0-3N)RGYAAC-3’ present on promoters. Probably activates transcription of the testis- specific histone gene HIST1H1T (By similarity) | 0.506 |
GIT1 | RUSC2 | ENSP00000378338 | ENSP00000393922 | ARF GTPase-activating protein GIT1; GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine- phosphorylated paxillin in cytoplasmic complexes. Involved in the regulation of cytokinesis; the function may involve SDCCAG3 and [...] | Iporin; RUN and SH3 domain containing 2 | 0.679 |
JUN | MAPK15 | ENSP00000360266 | ENSP00000337691 | Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5’-TGA[CG]TCA-3’. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells. Binds to the USP28 promoter in colorectal cancer (CRC) cells; Basic leucine zipper proteins | Mitogen-activated protein kinase 15; In vitro, phosphorylates MBP; Mitogen-activated protein kinases | 0.671 |
JUN | MBP | ENSP00000360266 | ENSP00000380958 | Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5’-TGA[CG]TCA-3’. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells. Binds to the USP28 promoter in colorectal cancer (CRC) cells; Basic leucine zipper proteins | Myelin basic protein; The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T- ce [...] | 0.447 |
LMLN | MAPK15 | ENSP00000410926 | ENSP00000337691 | Leishmanolysin-like peptidase; Metalloprotease essential for the coordination of mitotic progression, and also plays a role in cell migration | Mitogen-activated protein kinase 15; In vitro, phosphorylates MBP; Mitogen-activated protein kinases | 0.579 |
MAPK15 | CLIC1 | ENSP00000337691 | ENSP00000364935 | Mitogen-activated protein kinase 15; In vitro, phosphorylates MBP; Mitogen-activated protein kinases | Chloride intracellular channel protein 1; Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle | 0.716 |
MAPK15 | CLIC2 | ENSP00000337691 | ENSP00000358460 | Mitogen-activated protein kinase 15; In vitro, phosphorylates MBP; Mitogen-activated protein kinases | Chloride intracellular channel protein 2; Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx | 0.800 |
MAPK15 | CLIC3 | ENSP00000337691 | ENSP00000419378 | Mitogen-activated protein kinase 15; In vitro, phosphorylates MBP; Mitogen-activated protein kinases | Chloride intracellular channel protein 3; Can insert into membranes and form chloride ion channels. May participate in cellular growth control; Belongs to the chloride channel CLIC family | 0.939 |
MAPK15 | GIT1 | ENSP00000337691 | ENSP00000378338 | Mitogen-activated protein kinase 15; In vitro, phosphorylates MBP; Mitogen-activated protein kinases | ARF GTPase-activating protein GIT1; GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine- phosphorylated paxillin in cytoplasmic complexes. Involved in the regulation of cytokinesis; the function may involve SDCCAG3 and [...] | 0.646 |
MAPK15 | JUN | ENSP00000337691 | ENSP00000360266 | Mitogen-activated protein kinase 15; In vitro, phosphorylates MBP; Mitogen-activated protein kinases | Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5’-TGA[CG]TCA-3’. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells. Binds to the USP28 promoter in colorectal cancer (CRC) cells; Basic leucine zipper proteins | 0.671 |