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  • 11.0 [archived version]
STRINGSTRING
POM121L1P POM121L1P ALPP ALPP ALPPL2 ALPPL2 ALPI ALPI TGM2 TGM2 GGT1 GGT1 ALPL ALPL GGTLC1 GGTLC1 TGM3 TGM3 LOR LOR TGM1 TGM1
"GGTLC1" - Gamma-glutamyltransferase light chain 1 in Homo sapiens
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
GGTLC1Gamma-glutamyltransferase light chain 1; Gamma-glutamyltransferases (225 aa)    
Predicted Functional Partners:
TGM3
Protein-glutamine gamma-glutamyltransferase E; Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the g [...] (693 aa)
            
  0.747
GGT1
Glutathione hydrolase 1 proenzyme; Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione ( [...] (569 aa)
    
   
0.676
LOR
Loricrin; Major keratinocyte cell envelope protein; Cornified envelope precursor family (312 aa)
            
  0.640
ALPI
Alkaline phosphatase, intestinal (528 aa)
        
 
  0.628
ALPPL2
Alkaline phosphatase, placental like 2 (532 aa)
        
 
  0.627
ALPP
Alkaline phosphatase, placental (535 aa)
        
 
  0.603
TGM1
Protein-glutamine gamma-glutamyltransferase K; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross- linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation; Belongs to the transglutaminase superfamily. Transglutaminase family (817 aa)
            
  0.600
ALPL
Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme may play a role in skeletal mineralization; Belongs to the alkaline phosphatase family (524 aa)
      
 
  0.575
POM121L1P
annotation not available (429 aa)
            
  0.561
TGM2
Protein-glutamine gamma-glutamyltransferase 2; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins; Transglutaminases (687 aa)
            
  0.559
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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