| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C4BPA | PNRC1 | ENSP00000356037 | ENSP00000336931 | C4b-binding protein alpha chain; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component; Sushi domain containing | Proline-rich nuclear receptor coactivator 1; Nuclear receptor coactivator. May play a role in signal transduction | 0.648 |
| CRKL | DCP1A | ENSP00000346300 | ENSP00000476046 | Crk-like protein; May mediate the transduction of intracellular signals; SH2 domain containing | mRNA-decapping enzyme 1A; Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7- methyl guanine cap structure from mRNA molecules, yielding a 5’- phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1; Belongs to the DCP1 family | 0.562 |
| CRKL | PNRC1 | ENSP00000346300 | ENSP00000336931 | Crk-like protein; May mediate the transduction of intracellular signals; SH2 domain containing | Proline-rich nuclear receptor coactivator 1; Nuclear receptor coactivator. May play a role in signal transduction | 0.622 |
| DCP1A | CRKL | ENSP00000476046 | ENSP00000346300 | mRNA-decapping enzyme 1A; Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7- methyl guanine cap structure from mRNA molecules, yielding a 5’- phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1; Belongs to the DCP1 family | Crk-like protein; May mediate the transduction of intracellular signals; SH2 domain containing | 0.562 |
| DCP1A | DCP1B | ENSP00000476046 | ENSP00000280665 | mRNA-decapping enzyme 1A; Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7- methyl guanine cap structure from mRNA molecules, yielding a 5’- phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1; Belongs to the DCP1 family | mRNA-decapping enzyme 1B; May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5’-phosphorylated mRNA fragment and 7m-GDP (By similarity) | 0.979 |
| DCP1A | PNRC1 | ENSP00000476046 | ENSP00000336931 | mRNA-decapping enzyme 1A; Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7- methyl guanine cap structure from mRNA molecules, yielding a 5’- phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1; Belongs to the DCP1 family | Proline-rich nuclear receptor coactivator 1; Nuclear receptor coactivator. May play a role in signal transduction | 0.764 |
| DCP1B | DCP1A | ENSP00000280665 | ENSP00000476046 | mRNA-decapping enzyme 1B; May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5’-phosphorylated mRNA fragment and 7m-GDP (By similarity) | mRNA-decapping enzyme 1A; Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7- methyl guanine cap structure from mRNA molecules, yielding a 5’- phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1; Belongs to the DCP1 family | 0.979 |
| DCP1B | PNRC1 | ENSP00000280665 | ENSP00000336931 | mRNA-decapping enzyme 1B; May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5’-phosphorylated mRNA fragment and 7m-GDP (By similarity) | Proline-rich nuclear receptor coactivator 1; Nuclear receptor coactivator. May play a role in signal transduction | 0.753 |
| NDUFB9 | PNRC1 | ENSP00000276689 | ENSP00000336931 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone | Proline-rich nuclear receptor coactivator 1; Nuclear receptor coactivator. May play a role in signal transduction | 0.641 |
| NOC3L | PNRC1 | ENSP00000360412 | ENSP00000336931 | Nucleolar complex protein 3 homolog; May be required for adipogenesis; Armadillo-like helical domain containing | Proline-rich nuclear receptor coactivator 1; Nuclear receptor coactivator. May play a role in signal transduction | 0.599 |
| PNRC1 | C4BPA | ENSP00000336931 | ENSP00000356037 | Proline-rich nuclear receptor coactivator 1; Nuclear receptor coactivator. May play a role in signal transduction | C4b-binding protein alpha chain; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component; Sushi domain containing | 0.648 |
| PNRC1 | CRKL | ENSP00000336931 | ENSP00000346300 | Proline-rich nuclear receptor coactivator 1; Nuclear receptor coactivator. May play a role in signal transduction | Crk-like protein; May mediate the transduction of intracellular signals; SH2 domain containing | 0.622 |
| PNRC1 | DCP1A | ENSP00000336931 | ENSP00000476046 | Proline-rich nuclear receptor coactivator 1; Nuclear receptor coactivator. May play a role in signal transduction | mRNA-decapping enzyme 1A; Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7- methyl guanine cap structure from mRNA molecules, yielding a 5’- phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1; Belongs to the DCP1 family | 0.764 |
| PNRC1 | DCP1B | ENSP00000336931 | ENSP00000280665 | Proline-rich nuclear receptor coactivator 1; Nuclear receptor coactivator. May play a role in signal transduction | mRNA-decapping enzyme 1B; May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5’-phosphorylated mRNA fragment and 7m-GDP (By similarity) | 0.753 |
| PNRC1 | NDUFB9 | ENSP00000336931 | ENSP00000276689 | Proline-rich nuclear receptor coactivator 1; Nuclear receptor coactivator. May play a role in signal transduction | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone | 0.641 |
| PNRC1 | NOC3L | ENSP00000336931 | ENSP00000360412 | Proline-rich nuclear receptor coactivator 1; Nuclear receptor coactivator. May play a role in signal transduction | Nucleolar complex protein 3 homolog; May be required for adipogenesis; Armadillo-like helical domain containing | 0.599 |
| PNRC1 | SSNA1 | ENSP00000336931 | ENSP00000313752 | Proline-rich nuclear receptor coactivator 1; Nuclear receptor coactivator. May play a role in signal transduction | SS nuclear autoantigen 1 | 0.662 |
| PNRC1 | STS | ENSP00000336931 | ENSP00000217961 | Proline-rich nuclear receptor coactivator 1; Nuclear receptor coactivator. May play a role in signal transduction | Steryl-sulfatase; Conversion of sulfated steroid precursors to estrogens during pregnancy; Sulfatases | 0.644 |
| PNRC1 | TMEM35 | ENSP00000336931 | ENSP00000362021 | Proline-rich nuclear receptor coactivator 1; Nuclear receptor coactivator. May play a role in signal transduction | Transmembrane protein 35A; A soluble peptide released by shedding may interact with NGFR and modulate neurite outgrowth | 0.703 |
| PNRC1 | TRIM5 | ENSP00000336931 | ENSP00000369373 | Proline-rich nuclear receptor coactivator 1; Nuclear receptor coactivator. May play a role in signal transduction | Tripartite motif-containing protein 5; Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also [...] | 0.621 |
