IQCH protein (human) - STRING database

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IQCH

IQ domain-containing protein H; May play a regulatory role in spermatogenesis (1027 aa)

Predicted Functional Partners:

LDHA

0.756

MTL5

0.557

SERPINB12

0.531

PKD2L2

0.521

CATSPER1

0.491

CACNG5

0.451

ZBTB7A

0.447

C15orf61

0.441

IDI2

0.410

FEM1B

0.405

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C15orf61	IQCH	ENSP00000342254	ENSP00000336861	Uncharacterized protein C15orf61; Chromosome 15 open reading frame 61	IQ domain-containing protein H; May play a regulatory role in spermatogenesis	0.441
CACNG5	IQCH	ENSP00000436836	ENSP00000336861	Voltage-dependent calcium channel gamma-5 subunit; Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity); Calcium channel auxiliary gamma subunits	IQ domain-containing protein H; May play a regulatory role in spermatogenesis	0.451
CATSPER1	IQCH	ENSP00000309052	ENSP00000336861	Cation channel sperm-associated protein 1; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte; Cation channels sperm associated	IQ domain-containing protein H; May play a regulatory role in spermatogenesis	0.491
FEM1B	IQCH	ENSP00000307298	ENSP00000336861	Protein fem-1 homolog B; Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1; Belongs to the fem-1 family	IQ domain-containing protein H; May play a regulatory role in spermatogenesis	0.405
IDI2	IQCH	ENSP00000277517	ENSP00000336861	Isopentenyl-diphosphate delta-isomerase 2; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)	IQ domain-containing protein H; May play a regulatory role in spermatogenesis	0.410
IDI2	SERPINB12	ENSP00000277517	ENSP00000269491	Isopentenyl-diphosphate delta-isomerase 2; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)	Serpin B12; Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator; Belongs to the serpin family. Ov-serpin subfamily	0.400
IQCH	C15orf61	ENSP00000336861	ENSP00000342254	IQ domain-containing protein H; May play a regulatory role in spermatogenesis	Uncharacterized protein C15orf61; Chromosome 15 open reading frame 61	0.441
IQCH	CACNG5	ENSP00000336861	ENSP00000436836	IQ domain-containing protein H; May play a regulatory role in spermatogenesis	Voltage-dependent calcium channel gamma-5 subunit; Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity); Calcium channel auxiliary gamma subunits	0.451
IQCH	CATSPER1	ENSP00000336861	ENSP00000309052	IQ domain-containing protein H; May play a regulatory role in spermatogenesis	Cation channel sperm-associated protein 1; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte; Cation channels sperm associated	0.491
IQCH	FEM1B	ENSP00000336861	ENSP00000307298	IQ domain-containing protein H; May play a regulatory role in spermatogenesis	Protein fem-1 homolog B; Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1; Belongs to the fem-1 family	0.405
IQCH	IDI2	ENSP00000336861	ENSP00000277517	IQ domain-containing protein H; May play a regulatory role in spermatogenesis	Isopentenyl-diphosphate delta-isomerase 2; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)	0.410
IQCH	LDHA	ENSP00000336861	ENSP00000445175	IQ domain-containing protein H; May play a regulatory role in spermatogenesis	Lactate dehydrogenase A; Belongs to the LDH/MDH superfamily. LDH family	0.756
IQCH	MTL5	ENSP00000336861	ENSP00000255087	IQ domain-containing protein H; May play a regulatory role in spermatogenesis	Tesmin; May have a role in spermatogenesis; Belongs to the lin-54 family	0.557
IQCH	PKD2L2	ENSP00000336861	ENSP00000290431	IQ domain-containing protein H; May play a regulatory role in spermatogenesis	Polycystic kidney disease 2-like 2 protein; May function as a subunit of a cation channel and play a role in fertilization; Belongs to the polycystin family	0.521
IQCH	SERPINB12	ENSP00000336861	ENSP00000269491	IQ domain-containing protein H; May play a regulatory role in spermatogenesis	Serpin B12; Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator; Belongs to the serpin family. Ov-serpin subfamily	0.531
IQCH	ZBTB7A	ENSP00000336861	ENSP00000323670	IQ domain-containing protein H; May play a regulatory role in spermatogenesis	Zinc finger and BTB domain-containing protein 7A; Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1- dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5’-[GA][CA]GACCCCCCCCC-3’ (By similarity); BTB domain containing	0.447
LDHA	IQCH	ENSP00000445175	ENSP00000336861	Lactate dehydrogenase A; Belongs to the LDH/MDH superfamily. LDH family	IQ domain-containing protein H; May play a regulatory role in spermatogenesis	0.756
MTL5	IQCH	ENSP00000255087	ENSP00000336861	Tesmin; May have a role in spermatogenesis; Belongs to the lin-54 family	IQ domain-containing protein H; May play a regulatory role in spermatogenesis	0.557
PKD2L2	IQCH	ENSP00000290431	ENSP00000336861	Polycystic kidney disease 2-like 2 protein; May function as a subunit of a cation channel and play a role in fertilization; Belongs to the polycystin family	IQ domain-containing protein H; May play a regulatory role in spermatogenesis	0.521
PKD2L2	SERPINB12	ENSP00000290431	ENSP00000269491	Polycystic kidney disease 2-like 2 protein; May function as a subunit of a cation channel and play a role in fertilization; Belongs to the polycystin family	Serpin B12; Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator; Belongs to the serpin family. Ov-serpin subfamily	0.484

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