| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACBD3 | TBC1D22A | ENSP00000355777 | ENSP00000336724 | Golgi resident protein GCP60; Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi. Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (By similarity). Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase; A-kinase anchoring proteins | TBC1 domain family member 22A; May act as a GTPase-activating protein for Rab family protein(s) | 0.851 |
| CALN1 | SLC35D1 | ENSP00000378690 | ENSP00000235345 | Calcium-binding protein 8; Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity (By similarity). May play a role in the physiology of neurons and is potentially important in memory and learning; EF-hand domain containing | UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter; Transports both UDP-glucuronic acid (UDP-GlcA) and UDP- N-acetylgalactosamine (UDP-GalNAc) from the cytoplasm into the endoplasmic reticulum lumen. Plays a role in chondroitin sulfate biosynthesis, which is important for formation of cartilage extracellular matrix and normal skeletal development (By similarity); Solute carriers | 0.561 |
| CALN1 | TBC1D22A | ENSP00000378690 | ENSP00000336724 | Calcium-binding protein 8; Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity (By similarity). May play a role in the physiology of neurons and is potentially important in memory and learning; EF-hand domain containing | TBC1 domain family member 22A; May act as a GTPase-activating protein for Rab family protein(s) | 0.654 |
| GRTP1 | TBC1D20 | ENSP00000364579 | ENSP00000346139 | Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s) | TBC1 domain family member 20; GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude | 0.622 |
| GRTP1 | TBC1D21 | ENSP00000364579 | ENSP00000300504 | Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s) | TBC1 domain family member 21; May act as a GTPase-activating protein for Rab family protein(s). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity | 0.510 |
| GRTP1 | TBC1D22A | ENSP00000364579 | ENSP00000336724 | Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s) | TBC1 domain family member 22A; May act as a GTPase-activating protein for Rab family protein(s) | 0.665 |
| MICU1 | TBC1D22A | ENSP00000354415 | ENSP00000336724 | Calcium uptake protein 1, mitochondrial; Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake. Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening. Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm. [...] | TBC1 domain family member 22A; May act as a GTPase-activating protein for Rab family protein(s) | 0.671 |
| MOSPD3 | TBC1D22A | ENSP00000377522 | ENSP00000336724 | Motile sperm domain containing 3 | TBC1 domain family member 22A; May act as a GTPase-activating protein for Rab family protein(s) | 0.606 |
| RABL2A | TBC1D22A | ENSP00000376872 | ENSP00000336724 | Rab-like protein 2A; Plays an essential role in male fertility, sperm intra- flagellar transport, and tail assembly. Binds, in a GTP-regulated manner, to a specific set of effector proteins including key proteins involved in cilia development and function and delivers them into the growing sperm tail; RAB like GTPases | TBC1 domain family member 22A; May act as a GTPase-activating protein for Rab family protein(s) | 0.651 |
| RABL2A | ZBED4 | ENSP00000376872 | ENSP00000216268 | Rab-like protein 2A; Plays an essential role in male fertility, sperm intra- flagellar transport, and tail assembly. Binds, in a GTP-regulated manner, to a specific set of effector proteins including key proteins involved in cilia development and function and delivers them into the growing sperm tail; RAB like GTPases | Zinc finger BED-type containing 4 | 0.557 |
| SLC35D1 | CALN1 | ENSP00000235345 | ENSP00000378690 | UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter; Transports both UDP-glucuronic acid (UDP-GlcA) and UDP- N-acetylgalactosamine (UDP-GalNAc) from the cytoplasm into the endoplasmic reticulum lumen. Plays a role in chondroitin sulfate biosynthesis, which is important for formation of cartilage extracellular matrix and normal skeletal development (By similarity); Solute carriers | Calcium-binding protein 8; Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity (By similarity). May play a role in the physiology of neurons and is potentially important in memory and learning; EF-hand domain containing | 0.561 |
| SLC35D1 | TBC1D22A | ENSP00000235345 | ENSP00000336724 | UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter; Transports both UDP-glucuronic acid (UDP-GlcA) and UDP- N-acetylgalactosamine (UDP-GalNAc) from the cytoplasm into the endoplasmic reticulum lumen. Plays a role in chondroitin sulfate biosynthesis, which is important for formation of cartilage extracellular matrix and normal skeletal development (By similarity); Solute carriers | TBC1 domain family member 22A; May act as a GTPase-activating protein for Rab family protein(s) | 0.602 |
| TBC1D20 | GRTP1 | ENSP00000346139 | ENSP00000364579 | TBC1 domain family member 20; GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude | Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s) | 0.622 |
| TBC1D20 | TBC1D21 | ENSP00000346139 | ENSP00000300504 | TBC1 domain family member 20; GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude | TBC1 domain family member 21; May act as a GTPase-activating protein for Rab family protein(s). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity | 0.630 |
| TBC1D20 | TBC1D22A | ENSP00000346139 | ENSP00000336724 | TBC1 domain family member 20; GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude | TBC1 domain family member 22A; May act as a GTPase-activating protein for Rab family protein(s) | 0.597 |
| TBC1D21 | GRTP1 | ENSP00000300504 | ENSP00000364579 | TBC1 domain family member 21; May act as a GTPase-activating protein for Rab family protein(s). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity | Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s) | 0.510 |
| TBC1D21 | TBC1D20 | ENSP00000300504 | ENSP00000346139 | TBC1 domain family member 21; May act as a GTPase-activating protein for Rab family protein(s). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity | TBC1 domain family member 20; GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude | 0.630 |
| TBC1D21 | TBC1D22A | ENSP00000300504 | ENSP00000336724 | TBC1 domain family member 21; May act as a GTPase-activating protein for Rab family protein(s). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity | TBC1 domain family member 22A; May act as a GTPase-activating protein for Rab family protein(s) | 0.606 |
| TBC1D22A | ACBD3 | ENSP00000336724 | ENSP00000355777 | TBC1 domain family member 22A; May act as a GTPase-activating protein for Rab family protein(s) | Golgi resident protein GCP60; Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi. Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (By similarity). Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase; A-kinase anchoring proteins | 0.851 |
| TBC1D22A | CALN1 | ENSP00000336724 | ENSP00000378690 | TBC1 domain family member 22A; May act as a GTPase-activating protein for Rab family protein(s) | Calcium-binding protein 8; Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity (By similarity). May play a role in the physiology of neurons and is potentially important in memory and learning; EF-hand domain containing | 0.654 |
