• Version:
  • 11.0 [archived version]
STRINGSTRING
STAP2 STAP2 CDR2 CDR2 TMEM128 TMEM128 TMEM74B TMEM74B HID1 HID1 OTOP2 OTOP2 CDR2L CDR2L FADS6 FADS6 RPSA RPSA ZCCHC12 ZCCHC12 EMILIN2 EMILIN2
"CDR2L" - Cerebellar degeneration related protein 2 like in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDR2LCerebellar degeneration related protein 2 like (465 aa)    
Predicted Functional Partners:
ZCCHC12
Zinc finger CCHC domain-containing protein 12; Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression (By similarity); Paraneoplastic Ma antigens (402 aa)
     
   
  0.932
OTOP2
Otopetrin-2; Otopetrin 2 (562 aa)
     
   
  0.792
TMEM128
Transmembrane protein 128 (165 aa)
           
  0.736
CDR2
Cerebellar degeneration related protein 2 (454 aa)
       
 
0.732
RPSA
40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA (295 aa)
       
      0.719
HID1
Protein HID1; May play an important role in the development of cancers in a broad range of tissues (788 aa)
     
   
  0.709
EMILIN2
EMILIN-2; May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity; EMI domain containing (1053 aa)
           
  0.692
FADS6
Fatty acid desaturase 6; Belongs to the fatty acid desaturase type 1 family (368 aa)
           
  0.626
TMEM74B
Transmembrane protein 74B (256 aa)
           
  0.579
STAP2
Signal transducing adaptor family member 2 (449 aa)
           
  0.577
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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