node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASPM | SPATA21 | ENSP00000356379 | ENSP00000335612 | Abnormal spindle-like microcephaly-associated protein; Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex [...] | Spermatogenesis-associated protein 21; Involved in the differentiation of haploid spermatids; EF-hand domain containing | 0.461 |
ENSG00000273748 | SPATA21 | ENSP00000479921 | ENSP00000335612 | annotation not available | Spermatogenesis-associated protein 21; Involved in the differentiation of haploid spermatids; EF-hand domain containing | 0.418 |
GLYAT | SPATA21 | ENSP00000484592 | ENSP00000335612 | Glycine N-acyltransferase; Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid | Spermatogenesis-associated protein 21; Involved in the differentiation of haploid spermatids; EF-hand domain containing | 0.446 |
JADE3 | OR1L3 | ENSP00000481850 | ENSP00000302863 | Protein Jade-3; Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo; PHD finger proteins | Olfactory receptor 1L3; Odorant receptor; Olfactory receptors, family 1 | 0.542 |
JADE3 | SPATA21 | ENSP00000481850 | ENSP00000335612 | Protein Jade-3; Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo; PHD finger proteins | Spermatogenesis-associated protein 21; Involved in the differentiation of haploid spermatids; EF-hand domain containing | 0.530 |
MYH10 | SPATA21 | ENSP00000353590 | ENSP00000335612 | Myosin-10; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family | Spermatogenesis-associated protein 21; Involved in the differentiation of haploid spermatids; EF-hand domain containing | 0.634 |
OBSCN | SPATA21 | ENSP00000455507 | ENSP00000335612 | Obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF; Fibronectin type III domain containing | Spermatogenesis-associated protein 21; Involved in the differentiation of haploid spermatids; EF-hand domain containing | 0.601 |
OR1L3 | JADE3 | ENSP00000302863 | ENSP00000481850 | Olfactory receptor 1L3; Odorant receptor; Olfactory receptors, family 1 | Protein Jade-3; Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo; PHD finger proteins | 0.542 |
OR1L3 | PPCS | ENSP00000302863 | ENSP00000361642 | Olfactory receptor 1L3; Odorant receptor; Olfactory receptors, family 1 | Phosphopantothenate--cysteine ligase; Catalyzes the first step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4’- phosphopantothenate to form 4-phosphopantothenoylcysteine; Belongs to the PPC synthetase family | 0.420 |
OR1L3 | SPATA21 | ENSP00000302863 | ENSP00000335612 | Olfactory receptor 1L3; Odorant receptor; Olfactory receptors, family 1 | Spermatogenesis-associated protein 21; Involved in the differentiation of haploid spermatids; EF-hand domain containing | 0.669 |
PPCS | OR1L3 | ENSP00000361642 | ENSP00000302863 | Phosphopantothenate--cysteine ligase; Catalyzes the first step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4’- phosphopantothenate to form 4-phosphopantothenoylcysteine; Belongs to the PPC synthetase family | Olfactory receptor 1L3; Odorant receptor; Olfactory receptors, family 1 | 0.420 |
PPCS | SPATA21 | ENSP00000361642 | ENSP00000335612 | Phosphopantothenate--cysteine ligase; Catalyzes the first step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4’- phosphopantothenate to form 4-phosphopantothenoylcysteine; Belongs to the PPC synthetase family | Spermatogenesis-associated protein 21; Involved in the differentiation of haploid spermatids; EF-hand domain containing | 0.431 |
SLC35A5 | SPATA21 | ENSP00000417654 | ENSP00000335612 | Probable UDP-sugar transporter protein SLC35A5; Solute carrier family 35 member A5 | Spermatogenesis-associated protein 21; Involved in the differentiation of haploid spermatids; EF-hand domain containing | 0.557 |
SPATA21 | ASPM | ENSP00000335612 | ENSP00000356379 | Spermatogenesis-associated protein 21; Involved in the differentiation of haploid spermatids; EF-hand domain containing | Abnormal spindle-like microcephaly-associated protein; Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex [...] | 0.461 |
SPATA21 | ENSG00000273748 | ENSP00000335612 | ENSP00000479921 | Spermatogenesis-associated protein 21; Involved in the differentiation of haploid spermatids; EF-hand domain containing | annotation not available | 0.418 |
SPATA21 | GLYAT | ENSP00000335612 | ENSP00000484592 | Spermatogenesis-associated protein 21; Involved in the differentiation of haploid spermatids; EF-hand domain containing | Glycine N-acyltransferase; Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid | 0.446 |
SPATA21 | JADE3 | ENSP00000335612 | ENSP00000481850 | Spermatogenesis-associated protein 21; Involved in the differentiation of haploid spermatids; EF-hand domain containing | Protein Jade-3; Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo; PHD finger proteins | 0.530 |
SPATA21 | MYH10 | ENSP00000335612 | ENSP00000353590 | Spermatogenesis-associated protein 21; Involved in the differentiation of haploid spermatids; EF-hand domain containing | Myosin-10; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family | 0.634 |
SPATA21 | OBSCN | ENSP00000335612 | ENSP00000455507 | Spermatogenesis-associated protein 21; Involved in the differentiation of haploid spermatids; EF-hand domain containing | Obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF; Fibronectin type III domain containing | 0.601 |
SPATA21 | OR1L3 | ENSP00000335612 | ENSP00000302863 | Spermatogenesis-associated protein 21; Involved in the differentiation of haploid spermatids; EF-hand domain containing | Olfactory receptor 1L3; Odorant receptor; Olfactory receptors, family 1 | 0.669 |