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  • 11.0 [archived version]
STRINGSTRING
SPTBN4 SPTBN4 USP3 USP3 LRIG3 LRIG3 CMTM2 CMTM2 CMTM7 CMTM7 CKLF CKLF CMTM6 CMTM6 BLNK BLNK CMTM3 CMTM3 CMTM8 CMTM8 CMTM1 CMTM1
"CMTM7" - CKLF like MARVEL transmembrane domain containing 7 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
CMTM7CKLF like MARVEL transmembrane domain containing 7; Belongs to the chemokine-like factor family (175 aa)    
Predicted Functional Partners:
CMTM8
CKLF like MARVEL transmembrane domain containing 8; Belongs to the chemokine-like factor family (173 aa)
 
       
  0.958
CMTM6
CKLF like MARVEL transmembrane domain containing 6; Belongs to the chemokine-like factor family (183 aa)
     
   
  0.908
CKLF
Chemokine-like factor; May play an important role in inflammation and regeneration of skeletal muscle. Partly inhibited by interleukin 10 (152 aa)
     
   
  0.903
CMTM1
CKLF like MARVEL transmembrane domain containing 1 (286 aa)
           
  0.800
CMTM2
CKLF like MARVEL transmembrane domain containing 2; Belongs to the chemokine-like factor family (248 aa)
           
  0.800
CMTM3
CKLF like MARVEL transmembrane domain containing 3; Belongs to the chemokine-like factor family (182 aa)
     
   
  0.739
USP3
Ubiquitin carboxyl-terminal hydrolase 3; Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin; Ubiquitin specific peptidases (520 aa)
           
  0.708
LRIG3
Leucine-rich repeats and immunoglobulin-like domains protein 3; May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity); I-set domain containing (1119 aa)
           
  0.653
BLNK
B-cell linker protein; Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR- media [...] (456 aa)
       
 
  0.632
SPTBN4
Spectrin beta chain, non-erythrocytic 4; Pleckstrin homology domain containing (2564 aa)
           
  0.626
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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