• Version:
  • 11.0 [archived version]
STRINGSTRING
DEFB1 DEFB1 DEFB115 DEFB115 DEFB131 DEFB131 DEFB135 DEFB135 DEFB113 DEFB113 DEFB121 DEFB121 DEFB118 DEFB118 DEFB129 DEFB129 DEFB128 DEFB128 DEFB112 DEFB112 DEFB114 DEFB114
"DEFB131" - Beta-defensin 131A in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DEFB131Beta-defensin 131A; Has antibacterial activity (Probable). Upon stimulation with lipoteichoic acid, promotes cytokines and chemokines production and secretion; Belongs to the beta-defensin family (70 aa)    
Predicted Functional Partners:
DEFB113
Beta-defensin 113; Has antibacterial activity; Defensins, beta (82 aa)
      
 
    0.905
DEFB114
Beta-defensin 114; Has a salt-sensitive antimicrobial activity against Gram-negative bacteria, including E.coli, Gram-positive, including S.aureus, and fungi, including C.albicans. Binds to and neutralizes bacterial lipopolysaccharides (LPS), abolishing TNF production by macrophages challenged with LPS. Rescues the LPS- induced reduction of sperm motility in vitro and may protect from LPS-induced lethality; Defensins, beta (69 aa)
      
 
    0.904
DEFB115
Beta-defensin 115; Has antibacterial activity; Defensins, beta (88 aa)
      
 
    0.904
DEFB1
Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility; Belongs to the beta-defensin family (68 aa)
          
  0.904
DEFB135
Beta-defensin 135; Has antibacterial activity; Defensins, beta (77 aa)
      
 
    0.904
DEFB118
Beta-defensin 118; Has antibacterial activity; Defensins, beta (123 aa)
      
 
    0.904
DEFB129
Beta-defensin 129; Has antibacterial activity; Defensins, beta (183 aa)
      
 
    0.903
DEFB121
Beta-defensin 121; Has antibacterial activity; Belongs to the beta-defensin family (76 aa)
      
 
    0.903
DEFB128
Beta-defensin 128; Has antibacterial activity; Defensins, beta (93 aa)
      
 
    0.903
DEFB112
Beta-defensin 112; Has antibacterial activity; Defensins, beta (113 aa)
      
 
    0.903
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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