node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATXN7L1 | FOXD2 | ENSP00000410759 | ENSP00000335493 | Ataxin-7-like protein 1; Ataxin 7 like 1 | Forkhead box protein D2; Probable transcription factor involved in embryogenesis and somatogenesis; Forkhead boxes | 0.636 |
ATXN7L1 | OTUD7A | ENSP00000410759 | ENSP00000305926 | Ataxin-7-like protein 1; Ataxin 7 like 1 | OTU domain-containing protein 7A; Has deubiquitinating activity towards ’Lys-11’-linked polyubiquitin chains; Belongs to the peptidase C64 family | 0.642 |
FOXD2 | ATXN7L1 | ENSP00000335493 | ENSP00000410759 | Forkhead box protein D2; Probable transcription factor involved in embryogenesis and somatogenesis; Forkhead boxes | Ataxin-7-like protein 1; Ataxin 7 like 1 | 0.636 |
FOXD2 | MLLT6 | ENSP00000335493 | ENSP00000479910 | Forkhead box protein D2; Probable transcription factor involved in embryogenesis and somatogenesis; Forkhead boxes | Protein AF-17; MLLT6, PHD finger containing | 0.445 |
FOXD2 | OTUD7A | ENSP00000335493 | ENSP00000305926 | Forkhead box protein D2; Probable transcription factor involved in embryogenesis and somatogenesis; Forkhead boxes | OTU domain-containing protein 7A; Has deubiquitinating activity towards ’Lys-11’-linked polyubiquitin chains; Belongs to the peptidase C64 family | 0.557 |
FOXD2 | RANBP3L | ENSP00000335493 | ENSP00000421853 | Forkhead box protein D2; Probable transcription factor involved in embryogenesis and somatogenesis; Forkhead boxes | Ran-binding protein 3-like; Nuclear export factor for BMP-specific SMAD1/5/8 that plays a critical role in terminating BMP signaling and regulating mesenchymal stem cell differentiation by blocking osteoblast differentiation to promote myogenic differention. Directly recognizes dephosphorylated SMAD1/5/8 and mediates their nuclear export in a Ran-dependent manner | 0.475 |
FOXD2 | SALL1 | ENSP00000335493 | ENSP00000251020 | Forkhead box protein D2; Probable transcription factor involved in embryogenesis and somatogenesis; Forkhead boxes | Sal-like protein 1; Transcriptional repressor involved in organogenesis; Zinc fingers C2H2-type | 0.448 |
FOXD2 | SH2D4A | ENSP00000335493 | ENSP00000265807 | Forkhead box protein D2; Probable transcription factor involved in embryogenesis and somatogenesis; Forkhead boxes | SH2 domain-containing protein 4A; Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function; Protein phosphatase 1 regulatory subunits | 0.509 |
FOXD2 | SIX2 | ENSP00000335493 | ENSP00000304502 | Forkhead box protein D2; Probable transcription factor involved in embryogenesis and somatogenesis; Forkhead boxes | Homeobox protein SIX2; Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Al [...] | 0.555 |
FOXD2 | ZBTB1 | ENSP00000335493 | ENSP00000451000 | Forkhead box protein D2; Probable transcription factor involved in embryogenesis and somatogenesis; Forkhead boxes | Zinc finger and BTB domain-containing protein 1; Acts as a transcriptional repressor. Represses cAMP-responsive element (CRE)-mediated transcriptional activation. In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis. Plays a key role in the transcriptional regulation of T lymphocyte development (By similarity); BTB domain containing | 0.473 |
FOXD2 | ZNF471 | ENSP00000335493 | ENSP00000309161 | Forkhead box protein D2; Probable transcription factor involved in embryogenesis and somatogenesis; Forkhead boxes | Zinc finger protein 471; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.482 |
FOXD2 | ZSCAN18 | ENSP00000335493 | ENSP00000470123 | Forkhead box protein D2; Probable transcription factor involved in embryogenesis and somatogenesis; Forkhead boxes | Zinc finger and SCAN domain-containing protein 18; May be involved in transcriptional regulation; SCAN domain containing | 0.460 |
MLLT6 | FOXD2 | ENSP00000479910 | ENSP00000335493 | Protein AF-17; MLLT6, PHD finger containing | Forkhead box protein D2; Probable transcription factor involved in embryogenesis and somatogenesis; Forkhead boxes | 0.445 |
MLLT6 | SH2D4A | ENSP00000479910 | ENSP00000265807 | Protein AF-17; MLLT6, PHD finger containing | SH2 domain-containing protein 4A; Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function; Protein phosphatase 1 regulatory subunits | 0.561 |
MLLT6 | ZBTB1 | ENSP00000479910 | ENSP00000451000 | Protein AF-17; MLLT6, PHD finger containing | Zinc finger and BTB domain-containing protein 1; Acts as a transcriptional repressor. Represses cAMP-responsive element (CRE)-mediated transcriptional activation. In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis. Plays a key role in the transcriptional regulation of T lymphocyte development (By similarity); BTB domain containing | 0.518 |
OTUD7A | ATXN7L1 | ENSP00000305926 | ENSP00000410759 | OTU domain-containing protein 7A; Has deubiquitinating activity towards ’Lys-11’-linked polyubiquitin chains; Belongs to the peptidase C64 family | Ataxin-7-like protein 1; Ataxin 7 like 1 | 0.642 |
OTUD7A | FOXD2 | ENSP00000305926 | ENSP00000335493 | OTU domain-containing protein 7A; Has deubiquitinating activity towards ’Lys-11’-linked polyubiquitin chains; Belongs to the peptidase C64 family | Forkhead box protein D2; Probable transcription factor involved in embryogenesis and somatogenesis; Forkhead boxes | 0.557 |
RANBP3L | FOXD2 | ENSP00000421853 | ENSP00000335493 | Ran-binding protein 3-like; Nuclear export factor for BMP-specific SMAD1/5/8 that plays a critical role in terminating BMP signaling and regulating mesenchymal stem cell differentiation by blocking osteoblast differentiation to promote myogenic differention. Directly recognizes dephosphorylated SMAD1/5/8 and mediates their nuclear export in a Ran-dependent manner | Forkhead box protein D2; Probable transcription factor involved in embryogenesis and somatogenesis; Forkhead boxes | 0.475 |
SALL1 | FOXD2 | ENSP00000251020 | ENSP00000335493 | Sal-like protein 1; Transcriptional repressor involved in organogenesis; Zinc fingers C2H2-type | Forkhead box protein D2; Probable transcription factor involved in embryogenesis and somatogenesis; Forkhead boxes | 0.448 |
SALL1 | SIX2 | ENSP00000251020 | ENSP00000304502 | Sal-like protein 1; Transcriptional repressor involved in organogenesis; Zinc fingers C2H2-type | Homeobox protein SIX2; Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Al [...] | 0.756 |