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  • 11.0 [archived version]
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ATXN7L1 ATXN7L1 ZSCAN18 ZSCAN18 OTUD7A OTUD7A MLLT6 MLLT6 RANBP3L RANBP3L FOXD2 FOXD2 SH2D4A SH2D4A ZBTB1 ZBTB1 SIX2 SIX2 SALL1 SALL1 ZNF471 ZNF471
"FOXD2" - Forkhead box protein D2 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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FOXD2Forkhead box protein D2; Probable transcription factor involved in embryogenesis and somatogenesis; Forkhead boxes (495 aa)    
Predicted Functional Partners:
ATXN7L1
Ataxin-7-like protein 1; Ataxin 7 like 1 (861 aa)
       
 
  0.636
OTUD7A
OTU domain-containing protein 7A; Has deubiquitinating activity towards ’Lys-11’-linked polyubiquitin chains; Belongs to the peptidase C64 family (926 aa)
           
  0.557
SIX2
Homeobox protein SIX2; Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Al [...] (291 aa)
           
  0.555
SH2D4A
SH2 domain-containing protein 4A; Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function; Protein phosphatase 1 regulatory subunits (454 aa)
           
  0.509
ZNF471
Zinc finger protein 471; May be involved in transcriptional regulation; Zinc fingers C2H2-type (626 aa)
       
 
  0.482
RANBP3L
Ran-binding protein 3-like; Nuclear export factor for BMP-specific SMAD1/5/8 that plays a critical role in terminating BMP signaling and regulating mesenchymal stem cell differentiation by blocking osteoblast differentiation to promote myogenic differention. Directly recognizes dephosphorylated SMAD1/5/8 and mediates their nuclear export in a Ran-dependent manner (490 aa)
           
  0.475
ZBTB1
Zinc finger and BTB domain-containing protein 1; Acts as a transcriptional repressor. Represses cAMP-responsive element (CRE)-mediated transcriptional activation. In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis. Plays a key role in the transcriptional regulation of T lymphocyte development (By similarity); BTB domain containing (713 aa)
       
 
  0.473
ZSCAN18
Zinc finger and SCAN domain-containing protein 18; May be involved in transcriptional regulation; SCAN domain containing (566 aa)
       
 
  0.460
SALL1
Sal-like protein 1; Transcriptional repressor involved in organogenesis; Zinc fingers C2H2-type (1324 aa)
       
 
  0.448
MLLT6
Protein AF-17; MLLT6, PHD finger containing (1093 aa)
       
 
  0.445
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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