| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C1QL4 | CCDC47 | ENSP00000335285 | ENSP00000225726 | Complement C1q-like protein 4; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). May inhibit adipocyte differentiation at an early stage of the process (By similarity); C1q and TNF related | Coiled-coil domain containing 47 | 0.641 |
| C1QL4 | FAM132A | ENSP00000335285 | ENSP00000329137 | Complement C1q-like protein 4; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). May inhibit adipocyte differentiation at an early stage of the process (By similarity); C1q and TNF related | Adipolin; Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue | 0.537 |
| C1QL4 | FAM132B | ENSP00000335285 | ENSP00000442304 | Complement C1q-like protein 4; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). May inhibit adipocyte differentiation at an early stage of the process (By similarity); C1q and TNF related | Erythroferrone; Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage- produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores. Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake; Belongs to the adipolin/erythroferrone family | 0.704 |
| C1QL4 | FNDC5 | ENSP00000335285 | ENSP00000362570 | Complement C1q-like protein 4; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). May inhibit adipocyte differentiation at an early stage of the process (By similarity); C1q and TNF related | Fibronectin type III domain-containing protein 5; Irisin- Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue; Fibronectin type III domain containing | 0.579 |
| C1QL4 | IBSP | ENSP00000335285 | ENSP00000226284 | Complement C1q-like protein 4; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). May inhibit adipocyte differentiation at an early stage of the process (By similarity); C1q and TNF related | Bone sialoprotein 2; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment; SIBLING family | 0.560 |
| C1QL4 | ICAM5 | ENSP00000335285 | ENSP00000221980 | Complement C1q-like protein 4; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). May inhibit adipocyte differentiation at an early stage of the process (By similarity); C1q and TNF related | Intercellular adhesion molecule 5; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2); Ig-like cell adhesion molecule family | 0.530 |
| C1QL4 | MXRA8 | ENSP00000335285 | ENSP00000399229 | Complement C1q-like protein 4; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). May inhibit adipocyte differentiation at an early stage of the process (By similarity); C1q and TNF related | Matrix remodeling-associated protein 8; May play a role in the maturation and maintenance of blood-brain barrier; V-set domain containing | 0.738 |
| C1QL4 | SEC31B | ENSP00000335285 | ENSP00000359370 | Complement C1q-like protein 4; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). May inhibit adipocyte differentiation at an early stage of the process (By similarity); C1q and TNF related | Protein transport protein Sec31B; As a component of the coat protein complex II (COPII), may function in vesicle budding and cargo export from the endoplasmic reticulum; Belongs to the WD repeat SEC31 family | 0.558 |
| C1QL4 | YPEL1 | ENSP00000335285 | ENSP00000342832 | Complement C1q-like protein 4; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). May inhibit adipocyte differentiation at an early stage of the process (By similarity); C1q and TNF related | Protein yippee-like 1; May play a role in epithelioid conversion of fibroblasts; Yippee like family | 0.733 |
| C1QL4 | YPEL4 | ENSP00000335285 | ENSP00000432648 | Complement C1q-like protein 4; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). May inhibit adipocyte differentiation at an early stage of the process (By similarity); C1q and TNF related | Protein yippee-like 4; Yippee like family; Belongs to the yippee family | 0.750 |
| CCDC47 | C1QL4 | ENSP00000225726 | ENSP00000335285 | Coiled-coil domain containing 47 | Complement C1q-like protein 4; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). May inhibit adipocyte differentiation at an early stage of the process (By similarity); C1q and TNF related | 0.641 |
| CCDC47 | MXRA8 | ENSP00000225726 | ENSP00000399229 | Coiled-coil domain containing 47 | Matrix remodeling-associated protein 8; May play a role in the maturation and maintenance of blood-brain barrier; V-set domain containing | 0.522 |
| FAM132A | C1QL4 | ENSP00000329137 | ENSP00000335285 | Adipolin; Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue | Complement C1q-like protein 4; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). May inhibit adipocyte differentiation at an early stage of the process (By similarity); C1q and TNF related | 0.537 |
| FAM132B | C1QL4 | ENSP00000442304 | ENSP00000335285 | Erythroferrone; Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage- produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores. Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake; Belongs to the adipolin/erythroferrone family | Complement C1q-like protein 4; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). May inhibit adipocyte differentiation at an early stage of the process (By similarity); C1q and TNF related | 0.704 |
| FAM132B | FNDC5 | ENSP00000442304 | ENSP00000362570 | Erythroferrone; Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage- produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores. Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake; Belongs to the adipolin/erythroferrone family | Fibronectin type III domain-containing protein 5; Irisin- Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue; Fibronectin type III domain containing | 0.472 |
| FNDC5 | C1QL4 | ENSP00000362570 | ENSP00000335285 | Fibronectin type III domain-containing protein 5; Irisin- Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue; Fibronectin type III domain containing | Complement C1q-like protein 4; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). May inhibit adipocyte differentiation at an early stage of the process (By similarity); C1q and TNF related | 0.579 |
| FNDC5 | FAM132B | ENSP00000362570 | ENSP00000442304 | Fibronectin type III domain-containing protein 5; Irisin- Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue; Fibronectin type III domain containing | Erythroferrone; Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage- produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores. Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake; Belongs to the adipolin/erythroferrone family | 0.472 |
| FNDC5 | YPEL1 | ENSP00000362570 | ENSP00000342832 | Fibronectin type III domain-containing protein 5; Irisin- Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue; Fibronectin type III domain containing | Protein yippee-like 1; May play a role in epithelioid conversion of fibroblasts; Yippee like family | 0.579 |
| FNDC5 | YPEL4 | ENSP00000362570 | ENSP00000432648 | Fibronectin type III domain-containing protein 5; Irisin- Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue; Fibronectin type III domain containing | Protein yippee-like 4; Yippee like family; Belongs to the yippee family | 0.611 |
| IBSP | C1QL4 | ENSP00000226284 | ENSP00000335285 | Bone sialoprotein 2; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment; SIBLING family | Complement C1q-like protein 4; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). May inhibit adipocyte differentiation at an early stage of the process (By similarity); C1q and TNF related | 0.560 |
