| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANGPTL5 | C19orf80 | ENSP00000335255 | ENSP00000479969 | Angiopoietin-related protein 5; Fibrinogen C domain containing; Angiopoietin like | Angiopoietin-like protein 8; Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels. May be involved in the metabolic transition between fasting and refeeding- required to direct fatty acids to adipose tissue for storage in the fed state (By similarity); Belongs to the ANGPTL8 family | 0.731 |
| ANGPTL5 | FGF1 | ENSP00000335255 | ENSP00000480791 | Angiopoietin-related protein 5; Fibrinogen C domain containing; Angiopoietin like | Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV-ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] | 0.477 |
| ANGPTL5 | GPIHBP1 | ENSP00000335255 | ENSP00000480053 | Angiopoietin-related protein 5; Fibrinogen C domain containing; Angiopoietin like | Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1; Plays a key role in the lipolytic processing of chylomicrons. Required for the transport of lipoprotein lipase LPL into the capillary lumen (By similarity); LY6/PLAUR domain containing | 0.440 |
| ANGPTL5 | IGFBP2 | ENSP00000335255 | ENSP00000233809 | Angiopoietin-related protein 5; Fibrinogen C domain containing; Angiopoietin like | Insulin-like growth factor-binding protein 2; Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors | 0.500 |
| ANGPTL5 | KIAA1377 | ENSP00000335255 | ENSP00000263468 | Angiopoietin-related protein 5; Fibrinogen C domain containing; Angiopoietin like | Centrosomal protein of 126 kDa; Participates in cytokinesis. Necessary for microtubules and mitotic spindle organization. Involved in primary cilium formation | 0.465 |
| ANGPTL5 | KLHL38 | ENSP00000335255 | ENSP00000321475 | Angiopoietin-related protein 5; Fibrinogen C domain containing; Angiopoietin like | Kelch-like protein 38; Kelch like family member 38; BTB domain containing | 0.466 |
| ANGPTL5 | LILRB2 | ENSP00000335255 | ENSP00000375629 | Angiopoietin-related protein 5; Fibrinogen C domain containing; Angiopoietin like | Leukocyte immunoglobulin-like receptor subfamily B member 2; Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions | 0.640 |
| ANGPTL5 | LILRB5 | ENSP00000335255 | ENSP00000406478 | Angiopoietin-related protein 5; Fibrinogen C domain containing; Angiopoietin like | Leukocyte immunoglobulin-like receptor subfamily B member 5; May act as receptor for class I MHC antigens; CD molecules | 0.444 |
| ANGPTL5 | LPL | ENSP00000335255 | ENSP00000309757 | Angiopoietin-related protein 5; Fibrinogen C domain containing; Angiopoietin like | Lipoprotein lipase; The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity); Belongs to the AB hydrolase superfamily. Lipase family | 0.571 |
| ANGPTL5 | THPO | ENSP00000335255 | ENSP00000204615 | Angiopoietin-related protein 5; Fibrinogen C domain containing; Angiopoietin like | Thrombopoietin; Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets; Endogenous ligands | 0.497 |
| C19orf80 | ANGPTL5 | ENSP00000479969 | ENSP00000335255 | Angiopoietin-like protein 8; Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels. May be involved in the metabolic transition between fasting and refeeding- required to direct fatty acids to adipose tissue for storage in the fed state (By similarity); Belongs to the ANGPTL8 family | Angiopoietin-related protein 5; Fibrinogen C domain containing; Angiopoietin like | 0.731 |
| C19orf80 | GPIHBP1 | ENSP00000479969 | ENSP00000480053 | Angiopoietin-like protein 8; Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels. May be involved in the metabolic transition between fasting and refeeding- required to direct fatty acids to adipose tissue for storage in the fed state (By similarity); Belongs to the ANGPTL8 family | Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1; Plays a key role in the lipolytic processing of chylomicrons. Required for the transport of lipoprotein lipase LPL into the capillary lumen (By similarity); LY6/PLAUR domain containing | 0.957 |
| C19orf80 | LPL | ENSP00000479969 | ENSP00000309757 | Angiopoietin-like protein 8; Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels. May be involved in the metabolic transition between fasting and refeeding- required to direct fatty acids to adipose tissue for storage in the fed state (By similarity); Belongs to the ANGPTL8 family | Lipoprotein lipase; The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity); Belongs to the AB hydrolase superfamily. Lipase family | 0.964 |
| FGF1 | ANGPTL5 | ENSP00000480791 | ENSP00000335255 | Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV-ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] | Angiopoietin-related protein 5; Fibrinogen C domain containing; Angiopoietin like | 0.477 |
| FGF1 | THPO | ENSP00000480791 | ENSP00000204615 | Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV-ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] | Thrombopoietin; Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets; Endogenous ligands | 0.427 |
| GPIHBP1 | ANGPTL5 | ENSP00000480053 | ENSP00000335255 | Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1; Plays a key role in the lipolytic processing of chylomicrons. Required for the transport of lipoprotein lipase LPL into the capillary lumen (By similarity); LY6/PLAUR domain containing | Angiopoietin-related protein 5; Fibrinogen C domain containing; Angiopoietin like | 0.440 |
| GPIHBP1 | C19orf80 | ENSP00000480053 | ENSP00000479969 | Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1; Plays a key role in the lipolytic processing of chylomicrons. Required for the transport of lipoprotein lipase LPL into the capillary lumen (By similarity); LY6/PLAUR domain containing | Angiopoietin-like protein 8; Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels. May be involved in the metabolic transition between fasting and refeeding- required to direct fatty acids to adipose tissue for storage in the fed state (By similarity); Belongs to the ANGPTL8 family | 0.957 |
| GPIHBP1 | LPL | ENSP00000480053 | ENSP00000309757 | Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1; Plays a key role in the lipolytic processing of chylomicrons. Required for the transport of lipoprotein lipase LPL into the capillary lumen (By similarity); LY6/PLAUR domain containing | Lipoprotein lipase; The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity); Belongs to the AB hydrolase superfamily. Lipase family | 0.993 |
| IGFBP2 | ANGPTL5 | ENSP00000233809 | ENSP00000335255 | Insulin-like growth factor-binding protein 2; Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors | Angiopoietin-related protein 5; Fibrinogen C domain containing; Angiopoietin like | 0.500 |
| KIAA1377 | ANGPTL5 | ENSP00000263468 | ENSP00000335255 | Centrosomal protein of 126 kDa; Participates in cytokinesis. Necessary for microtubules and mitotic spindle organization. Involved in primary cilium formation | Angiopoietin-related protein 5; Fibrinogen C domain containing; Angiopoietin like | 0.465 |
