| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANKRD29 | ANKRD37 | ENSP00000468354 | ENSP00000335147 | Ankyrin repeat domain-containing protein 29; Ankyrin repeat domain containing | Ankyrin repeat domain-containing protein 37; Ankyrin repeat domain containing | 0.509 |
| ANKRD37 | ANKRD29 | ENSP00000335147 | ENSP00000468354 | Ankyrin repeat domain-containing protein 37; Ankyrin repeat domain containing | Ankyrin repeat domain-containing protein 29; Ankyrin repeat domain containing | 0.509 |
| ANKRD37 | DTX3 | ENSP00000335147 | ENSP00000448696 | Ankyrin repeat domain-containing protein 37; Ankyrin repeat domain containing | Probable E3 ubiquitin-protein ligase DTX3; Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context (By similarity). Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity; Ring finger proteins | 0.527 |
| ANKRD37 | EGLN3 | ENSP00000335147 | ENSP00000250457 | Ankyrin repeat domain-containing protein 37; Ankyrin repeat domain containing | Egl nine homolog 3; Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site. Hydroxylated HIFs are then targeted for proteasomal degradation via the v [...] | 0.516 |
| ANKRD37 | FEM1B | ENSP00000335147 | ENSP00000307298 | Ankyrin repeat domain-containing protein 37; Ankyrin repeat domain containing | Protein fem-1 homolog B; Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1; Belongs to the fem-1 family | 0.800 |
| ANKRD37 | PRSS16 | ENSP00000335147 | ENSP00000230582 | Ankyrin repeat domain-containing protein 37; Ankyrin repeat domain containing | Thymus-specific serine protease; Protease that may play a role in T-cell development; Belongs to the peptidase S28 family | 0.619 |
| ANKRD37 | PYGO1 | ENSP00000335147 | ENSP00000302327 | Ankyrin repeat domain-containing protein 37; Ankyrin repeat domain containing | Pygopus homolog 1; Involved in signal transduction through the Wnt pathway; PHD finger proteins | 0.534 |
| ANKRD37 | SMNDC1 | ENSP00000335147 | ENSP00000358616 | Ankyrin repeat domain-containing protein 37; Ankyrin repeat domain containing | Survival of motor neuron-related-splicing factor 30; Necessary for spliceosome assembly. Overexpression causes apoptosis; Belongs to the SMN family | 0.527 |
| ANKRD37 | SPAG4 | ENSP00000335147 | ENSP00000363391 | Ankyrin repeat domain-containing protein 37; Ankyrin repeat domain containing | Sperm-associated antigen 4 protein; Involved in spermatogenesis. Required for sperm head formation but not required to establish and maintain general polarity of the sperm head. Required for anchoring and organization of the manchette. Required for targeting of SUN3 and probably SYNE1 through a probable SUN1-SYNE3 LINC complex to the nuclear envelope and involved in accurate posterior sperm head localization of the complex. May anchor SUN3 the nuclear envelope. Involved in maintenance of the nuclear envelope integrity. May assist the organization and assembly of outer dense fibers (ODF [...] | 0.607 |
| ANKRD37 | TMEM45A | ENSP00000335147 | ENSP00000319009 | Ankyrin repeat domain-containing protein 37; Ankyrin repeat domain containing | Transmembrane protein 45A; Belongs to the TMEM45 family | 0.521 |
| ANKRD37 | WSB1 | ENSP00000335147 | ENSP00000262394 | Ankyrin repeat domain-containing protein 37; Ankyrin repeat domain containing | WD repeat and SOCS box-containing protein 1; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation; WD repeat domain containing | 0.486 |
| DTX3 | ANKRD37 | ENSP00000448696 | ENSP00000335147 | Probable E3 ubiquitin-protein ligase DTX3; Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context (By similarity). Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity; Ring finger proteins | Ankyrin repeat domain-containing protein 37; Ankyrin repeat domain containing | 0.527 |
| DTX3 | PYGO1 | ENSP00000448696 | ENSP00000302327 | Probable E3 ubiquitin-protein ligase DTX3; Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context (By similarity). Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity; Ring finger proteins | Pygopus homolog 1; Involved in signal transduction through the Wnt pathway; PHD finger proteins | 0.691 |
| EGLN3 | ANKRD37 | ENSP00000250457 | ENSP00000335147 | Egl nine homolog 3; Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site. Hydroxylated HIFs are then targeted for proteasomal degradation via the v [...] | Ankyrin repeat domain-containing protein 37; Ankyrin repeat domain containing | 0.516 |
| FEM1B | ANKRD37 | ENSP00000307298 | ENSP00000335147 | Protein fem-1 homolog B; Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1; Belongs to the fem-1 family | Ankyrin repeat domain-containing protein 37; Ankyrin repeat domain containing | 0.800 |
| FEM1B | WSB1 | ENSP00000307298 | ENSP00000262394 | Protein fem-1 homolog B; Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1; Belongs to the fem-1 family | WD repeat and SOCS box-containing protein 1; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation; WD repeat domain containing | 0.906 |
| PRSS16 | ANKRD37 | ENSP00000230582 | ENSP00000335147 | Thymus-specific serine protease; Protease that may play a role in T-cell development; Belongs to the peptidase S28 family | Ankyrin repeat domain-containing protein 37; Ankyrin repeat domain containing | 0.619 |
| PRSS16 | SMNDC1 | ENSP00000230582 | ENSP00000358616 | Thymus-specific serine protease; Protease that may play a role in T-cell development; Belongs to the peptidase S28 family | Survival of motor neuron-related-splicing factor 30; Necessary for spliceosome assembly. Overexpression causes apoptosis; Belongs to the SMN family | 0.465 |
| PYGO1 | ANKRD37 | ENSP00000302327 | ENSP00000335147 | Pygopus homolog 1; Involved in signal transduction through the Wnt pathway; PHD finger proteins | Ankyrin repeat domain-containing protein 37; Ankyrin repeat domain containing | 0.534 |
| PYGO1 | DTX3 | ENSP00000302327 | ENSP00000448696 | Pygopus homolog 1; Involved in signal transduction through the Wnt pathway; PHD finger proteins | Probable E3 ubiquitin-protein ligase DTX3; Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context (By similarity). Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity; Ring finger proteins | 0.691 |
