HPDL protein (human) - STRING database

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Score

HPDL

4-hydroxyphenylpyruvate dioxygenase-like protein; May have dioxygenase activity (371 aa)

Predicted Functional Partners:

HGD

0.908

TAT

0.814

RIF1

0.800

FAH

0.778

C9orf78

0.589

TOE1

0.558

TOR1AIP1

0.552

DPYS

0.547

PAM

0.544

CWC27

0.534

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C9orf78	CWC27	ENSP00000361524	ENSP00000370460	Telomere length and silencing protein 1 homolog; Involved in the regulation of telomeric heterochromatin assembly and control of telomere length; Spliceosomal P complex	Peptidyl-prolyl cis-trans isomerase CWC27 homolog; PPIases accelerate the folding of proteins; Belongs to the cyclophilin-type PPIase family	0.429
C9orf78	HPDL	ENSP00000361524	ENSP00000335060	Telomere length and silencing protein 1 homolog; Involved in the regulation of telomeric heterochromatin assembly and control of telomere length; Spliceosomal P complex	4-hydroxyphenylpyruvate dioxygenase-like protein; May have dioxygenase activity	0.589
CWC27	C9orf78	ENSP00000370460	ENSP00000361524	Peptidyl-prolyl cis-trans isomerase CWC27 homolog; PPIases accelerate the folding of proteins; Belongs to the cyclophilin-type PPIase family	Telomere length and silencing protein 1 homolog; Involved in the regulation of telomeric heterochromatin assembly and control of telomere length; Spliceosomal P complex	0.429
CWC27	HPDL	ENSP00000370460	ENSP00000335060	Peptidyl-prolyl cis-trans isomerase CWC27 homolog; PPIases accelerate the folding of proteins; Belongs to the cyclophilin-type PPIase family	4-hydroxyphenylpyruvate dioxygenase-like protein; May have dioxygenase activity	0.534
DPYS	HPDL	ENSP00000276651	ENSP00000335060	Dihydropyrimidinase; Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6- dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate	4-hydroxyphenylpyruvate dioxygenase-like protein; May have dioxygenase activity	0.547
FAH	HGD	ENSP00000385080	ENSP00000283871	Fumarylacetoacetase; Fumarylacetoacetate hydrolase	Homogentisate 1,2-dioxygenase	0.974
FAH	HPDL	ENSP00000385080	ENSP00000335060	Fumarylacetoacetase; Fumarylacetoacetate hydrolase	4-hydroxyphenylpyruvate dioxygenase-like protein; May have dioxygenase activity	0.778
FAH	TAT	ENSP00000385080	ENSP00000348234	Fumarylacetoacetase; Fumarylacetoacetate hydrolase	Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine	0.869
HGD	FAH	ENSP00000283871	ENSP00000385080	Homogentisate 1,2-dioxygenase	Fumarylacetoacetase; Fumarylacetoacetate hydrolase	0.974
HGD	HPDL	ENSP00000283871	ENSP00000335060	Homogentisate 1,2-dioxygenase	4-hydroxyphenylpyruvate dioxygenase-like protein; May have dioxygenase activity	0.908
HGD	TAT	ENSP00000283871	ENSP00000348234	Homogentisate 1,2-dioxygenase	Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine	0.867
HPDL	C9orf78	ENSP00000335060	ENSP00000361524	4-hydroxyphenylpyruvate dioxygenase-like protein; May have dioxygenase activity	Telomere length and silencing protein 1 homolog; Involved in the regulation of telomeric heterochromatin assembly and control of telomere length; Spliceosomal P complex	0.589
HPDL	CWC27	ENSP00000335060	ENSP00000370460	4-hydroxyphenylpyruvate dioxygenase-like protein; May have dioxygenase activity	Peptidyl-prolyl cis-trans isomerase CWC27 homolog; PPIases accelerate the folding of proteins; Belongs to the cyclophilin-type PPIase family	0.534
HPDL	DPYS	ENSP00000335060	ENSP00000276651	4-hydroxyphenylpyruvate dioxygenase-like protein; May have dioxygenase activity	Dihydropyrimidinase; Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6- dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate	0.547
HPDL	FAH	ENSP00000335060	ENSP00000385080	4-hydroxyphenylpyruvate dioxygenase-like protein; May have dioxygenase activity	Fumarylacetoacetase; Fumarylacetoacetate hydrolase	0.778
HPDL	HGD	ENSP00000335060	ENSP00000283871	4-hydroxyphenylpyruvate dioxygenase-like protein; May have dioxygenase activity	Homogentisate 1,2-dioxygenase	0.908
HPDL	PAM	ENSP00000335060	ENSP00000306100	4-hydroxyphenylpyruvate dioxygenase-like protein; May have dioxygenase activity	Peptidyl-glycine alpha-amidating monooxygenase; Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity	0.544
HPDL	RIF1	ENSP00000335060	ENSP00000243326	4-hydroxyphenylpyruvate dioxygenase-like protein; May have dioxygenase activity	Telomere-associated protein RIF1; Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage- acts by promoting non-homologous end joining (NHEJ)- mediated repair of DSBs. In response to DNA damage, interacts with ATM-phosphorylated TP53BP1. Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs. Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs. In the [...]	0.800
HPDL	TAT	ENSP00000335060	ENSP00000348234	4-hydroxyphenylpyruvate dioxygenase-like protein; May have dioxygenase activity	Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine	0.814
HPDL	TOE1	ENSP00000335060	ENSP00000361162	4-hydroxyphenylpyruvate dioxygenase-like protein; May have dioxygenase activity	Target of EGR1 protein 1; Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3’-tail processing	0.558

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