| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AR | GGN | ENSP00000363822 | ENSP00000334940 | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | Gametogenetin; May be involved in spermatogenesis | 0.703 |
| AUH | GGN | ENSP00000364883 | ENSP00000334940 | Methylglutaconyl-CoA hydratase, mitochondrial; Catalyzes the conversion of 3-methylglutaconyl-CoA to 3- hydroxy-3-methylglutaryl-CoA. Also has itaconyl-CoA hydratase activity by converting itaconyl-CoA into citramalyl-CoA in the C5- dicarboxylate catabolism pathway. The C5- dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite. Has very low enoyl-CoA hydratase activity. Was originally identified as RNA-binding protein that binds in vitro to clustered 5’-AUUUA-3’ motifs | Gametogenetin; May be involved in spermatogenesis | 0.621 |
| CRTAP | GGN | ENSP00000323696 | ENSP00000334940 | Cartilage-associated protein; Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues; Belongs to the leprecan family | Gametogenetin; May be involved in spermatogenesis | 0.622 |
| CRTAP | LEPRE1 | ENSP00000323696 | ENSP00000236040 | Cartilage-associated protein; Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues; Belongs to the leprecan family | Prolyl 3-hydroxylase 1; Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro- Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts | 0.994 |
| FANCL | GGN | ENSP00000385021 | ENSP00000334940 | E3 ubiquitin-protein ligase FANCL; Ubiquitin ligase protein that mediates monoubiquitination of FANCD2 in the presence of UBE2T, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth; Fanconi anemia complementation groups | Gametogenetin; May be involved in spermatogenesis | 0.695 |
| GAN | GGN | ENSP00000476795 | ENSP00000334940 | Gigaxonin; Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB. Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival; BTB domain containing | Gametogenetin; May be involved in spermatogenesis | 0.593 |
| GGN | AR | ENSP00000334940 | ENSP00000363822 | Gametogenetin; May be involved in spermatogenesis | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | 0.703 |
| GGN | AUH | ENSP00000334940 | ENSP00000364883 | Gametogenetin; May be involved in spermatogenesis | Methylglutaconyl-CoA hydratase, mitochondrial; Catalyzes the conversion of 3-methylglutaconyl-CoA to 3- hydroxy-3-methylglutaryl-CoA. Also has itaconyl-CoA hydratase activity by converting itaconyl-CoA into citramalyl-CoA in the C5- dicarboxylate catabolism pathway. The C5- dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite. Has very low enoyl-CoA hydratase activity. Was originally identified as RNA-binding protein that binds in vitro to clustered 5’-AUUUA-3’ motifs | 0.621 |
| GGN | CRTAP | ENSP00000334940 | ENSP00000323696 | Gametogenetin; May be involved in spermatogenesis | Cartilage-associated protein; Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues; Belongs to the leprecan family | 0.622 |
| GGN | FANCL | ENSP00000334940 | ENSP00000385021 | Gametogenetin; May be involved in spermatogenesis | E3 ubiquitin-protein ligase FANCL; Ubiquitin ligase protein that mediates monoubiquitination of FANCD2 in the presence of UBE2T, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth; Fanconi anemia complementation groups | 0.695 |
| GGN | GAN | ENSP00000334940 | ENSP00000476795 | Gametogenetin; May be involved in spermatogenesis | Gigaxonin; Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB. Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival; BTB domain containing | 0.593 |
| GGN | GGNBP2 | ENSP00000334940 | ENSP00000478220 | Gametogenetin; May be involved in spermatogenesis | Gametogenetin-binding protein 2; May be involved in spermatogenesis | 0.701 |
| GGN | LEPRE1 | ENSP00000334940 | ENSP00000236040 | Gametogenetin; May be involved in spermatogenesis | Prolyl 3-hydroxylase 1; Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro- Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts | 0.620 |
| GGN | OAZ3 | ENSP00000334940 | ENSP00000313922 | Gametogenetin; May be involved in spermatogenesis | Ornithine decarboxylase antizyme 3; Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity. Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytoso [...] | 0.607 |
| GGN | PURA | ENSP00000334940 | ENSP00000332706 | Gametogenetin; May be involved in spermatogenesis | Transcriptional activator protein Pur-alpha; This is a probable transcription activator that specifically binds the purine-rich single strand of the PUR element located upstream of the MYC gene. May play a role in the initiation of DNA replication and in recombination | 0.626 |
| GGN | TGM6 | ENSP00000334940 | ENSP00000202625 | Gametogenetin; May be involved in spermatogenesis | Protein-glutamine gamma-glutamyltransferase 6; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins; Belongs to the transglutaminase superfamily. Transglutaminase family | 0.680 |
| GGNBP2 | GGN | ENSP00000478220 | ENSP00000334940 | Gametogenetin-binding protein 2; May be involved in spermatogenesis | Gametogenetin; May be involved in spermatogenesis | 0.701 |
| GGNBP2 | OAZ3 | ENSP00000478220 | ENSP00000313922 | Gametogenetin-binding protein 2; May be involved in spermatogenesis | Ornithine decarboxylase antizyme 3; Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity. Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytoso [...] | 0.426 |
| LEPRE1 | CRTAP | ENSP00000236040 | ENSP00000323696 | Prolyl 3-hydroxylase 1; Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro- Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts | Cartilage-associated protein; Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues; Belongs to the leprecan family | 0.994 |
| LEPRE1 | GGN | ENSP00000236040 | ENSP00000334940 | Prolyl 3-hydroxylase 1; Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro- Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts | Gametogenetin; May be involved in spermatogenesis | 0.620 |
