| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CHRND | GABRE | ENSP00000258385 | ENSP00000359353 | Acetylcholine receptor subunit delta; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Delta/CHRND sub-subfamily | Gamma-aminobutyric acid receptor subunit epsilon; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | 0.508 |
| CHRND | SCN3B | ENSP00000258385 | ENSP00000376523 | Acetylcholine receptor subunit delta; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Delta/CHRND sub-subfamily | Sodium channel subunit beta-3; Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity); Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family | 0.502 |
| CHRND | TMTC2 | ENSP00000258385 | ENSP00000322300 | Acetylcholine receptor subunit delta; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Delta/CHRND sub-subfamily | Transmembrane and tetratricopeptide repeat containing 2 | 0.558 |
| CHRND | TMTC3 | ENSP00000258385 | ENSP00000266712 | Acetylcholine receptor subunit delta; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Delta/CHRND sub-subfamily | Transmembrane and TPR repeat-containing protein 3; Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response; Tetratricopeptide repeat domain containing | 0.453 |
| CHRND | ZACN | ENSP00000258385 | ENSP00000334854 | Acetylcholine receptor subunit delta; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Delta/CHRND sub-subfamily | Zinc-activated ligand-gated ion channel; Zinc-activated ligand-gated ion channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family | 0.616 |
| DYNLL1 | ZACN | ENSP00000376297 | ENSP00000334854 | Dynein light chain 1, cytoplasmic; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures; Belongs to the dynein light chain family | Zinc-activated ligand-gated ion channel; Zinc-activated ligand-gated ion channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family | 0.511 |
| ERMARD | TMTC2 | ENSP00000355735 | ENSP00000322300 | Endoplasmic reticulum membrane-associated RNA degradation protein; May play a role in neuronal migration during embryonic development | Transmembrane and tetratricopeptide repeat containing 2 | 0.460 |
| ERMARD | ZACN | ENSP00000355735 | ENSP00000334854 | Endoplasmic reticulum membrane-associated RNA degradation protein; May play a role in neuronal migration during embryonic development | Zinc-activated ligand-gated ion channel; Zinc-activated ligand-gated ion channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family | 0.509 |
| EXOC7 | GALR2 | ENSP00000334100 | ENSP00000329684 | Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity) | Galanin receptor type 2; Receptor for the hormone galanin and GALP. Receptor for the hormone spexin-1. The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)) | 0.524 |
| EXOC7 | ZACN | ENSP00000334100 | ENSP00000334854 | Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity) | Zinc-activated ligand-gated ion channel; Zinc-activated ligand-gated ion channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family | 0.757 |
| GABRE | CHRND | ENSP00000359353 | ENSP00000258385 | Gamma-aminobutyric acid receptor subunit epsilon; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | Acetylcholine receptor subunit delta; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Delta/CHRND sub-subfamily | 0.508 |
| GABRE | SCN3B | ENSP00000359353 | ENSP00000376523 | Gamma-aminobutyric acid receptor subunit epsilon; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | Sodium channel subunit beta-3; Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity); Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family | 0.490 |
| GABRE | TMTC2 | ENSP00000359353 | ENSP00000322300 | Gamma-aminobutyric acid receptor subunit epsilon; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | Transmembrane and tetratricopeptide repeat containing 2 | 0.611 |
| GABRE | TMTC3 | ENSP00000359353 | ENSP00000266712 | Gamma-aminobutyric acid receptor subunit epsilon; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | Transmembrane and TPR repeat-containing protein 3; Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response; Tetratricopeptide repeat domain containing | 0.438 |
| GABRE | ZACN | ENSP00000359353 | ENSP00000334854 | Gamma-aminobutyric acid receptor subunit epsilon; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | Zinc-activated ligand-gated ion channel; Zinc-activated ligand-gated ion channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family | 0.632 |
| GALR2 | EXOC7 | ENSP00000329684 | ENSP00000334100 | Galanin receptor type 2; Receptor for the hormone galanin and GALP. Receptor for the hormone spexin-1. The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)) | Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity) | 0.524 |
| GALR2 | ZACN | ENSP00000329684 | ENSP00000334854 | Galanin receptor type 2; Receptor for the hormone galanin and GALP. Receptor for the hormone spexin-1. The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)) | Zinc-activated ligand-gated ion channel; Zinc-activated ligand-gated ion channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family | 0.801 |
| HTR3D | TMTC2 | ENSP00000371929 | ENSP00000322300 | 5-hydroxytryptamine receptor 3D; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3D sub-subfamily | Transmembrane and tetratricopeptide repeat containing 2 | 0.433 |
| HTR3D | ZACN | ENSP00000371929 | ENSP00000334854 | 5-hydroxytryptamine receptor 3D; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3D sub-subfamily | Zinc-activated ligand-gated ion channel; Zinc-activated ligand-gated ion channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family | 0.533 |
| SCN3B | CHRND | ENSP00000376523 | ENSP00000258385 | Sodium channel subunit beta-3; Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity); Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family | Acetylcholine receptor subunit delta; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Delta/CHRND sub-subfamily | 0.502 |
