node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C6orf52 | CCDC84 | ENSP00000259983 | ENSP00000334767 | Putative uncharacterized protein C6orf52; Chromosome 6 open reading frame 52 | Coiled-coil domain containing 84 | 0.626 |
C6orf52 | TMSL8 | ENSP00000259983 | ENSP00000472749 | Putative uncharacterized protein C6orf52; Chromosome 6 open reading frame 52 | Thymosin beta-15A; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity); Belongs to the thymosin beta family | 0.536 |
C6orf52 | TOR1AIP2 | ENSP00000259983 | ENSP00000356584 | Putative uncharacterized protein C6orf52; Chromosome 6 open reading frame 52 | Torsin-1A-interacting protein 2; Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity; Belongs to the TOR1AIP family | 0.626 |
CCDC84 | C6orf52 | ENSP00000334767 | ENSP00000259983 | Coiled-coil domain containing 84 | Putative uncharacterized protein C6orf52; Chromosome 6 open reading frame 52 | 0.626 |
CCDC84 | LYRM9 | ENSP00000334767 | ENSP00000368397 | Coiled-coil domain containing 84 | LYR motif containing 9; Belongs to the complex I LYR family. LYRM9 subfamily | 0.537 |
CCDC84 | PPIL3 | ENSP00000334767 | ENSP00000286175 | Coiled-coil domain containing 84 | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Cyclophilin peptidylprolyl isomerases | 0.548 |
CCDC84 | PRPF3 | ENSP00000334767 | ENSP00000315379 | Coiled-coil domain containing 84 | U4/U6 small nuclear ribonucleoprotein Prp3; Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome; U4/U6 small nucleolar ribonucleoprotein | 0.692 |
CCDC84 | SNRPG | ENSP00000334767 | ENSP00000272348 | Coiled-coil domain containing 84 | Small nuclear ribonucleoprotein G; Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Appears to function in the U7 snRNP complex that is involved in histone 3’-end processing | 0.663 |
CCDC84 | TMSL8 | ENSP00000334767 | ENSP00000472749 | Coiled-coil domain containing 84 | Thymosin beta-15A; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity); Belongs to the thymosin beta family | 0.602 |
CCDC84 | TOR1A | ENSP00000334767 | ENSP00000345719 | Coiled-coil domain containing 84 | Torsin-1A; Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular traffickin [...] | 0.629 |
CCDC84 | TOR1AIP2 | ENSP00000334767 | ENSP00000356584 | Coiled-coil domain containing 84 | Torsin-1A-interacting protein 2; Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity; Belongs to the TOR1AIP family | 0.732 |
CCDC84 | TUT1 | ENSP00000334767 | ENSP00000308000 | Coiled-coil domain containing 84 | Speckle targeted PIP5K1A-regulated poly(A) polymerase; Poly(A) polymerase that creates the 3’-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3’-end cleavage of pre-mRNAs- binds to the 3’UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3’UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher tha [...] | 0.874 |
CCDC84 | TXNL4B | ENSP00000334767 | ENSP00000268483 | Coiled-coil domain containing 84 | Thioredoxin-like protein 4B; Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition; Belongs to the DIM1 family | 0.540 |
LYRM9 | CCDC84 | ENSP00000368397 | ENSP00000334767 | LYR motif containing 9; Belongs to the complex I LYR family. LYRM9 subfamily | Coiled-coil domain containing 84 | 0.537 |
PPIL3 | CCDC84 | ENSP00000286175 | ENSP00000334767 | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Cyclophilin peptidylprolyl isomerases | Coiled-coil domain containing 84 | 0.548 |
PPIL3 | PRPF3 | ENSP00000286175 | ENSP00000315379 | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Cyclophilin peptidylprolyl isomerases | U4/U6 small nuclear ribonucleoprotein Prp3; Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome; U4/U6 small nucleolar ribonucleoprotein | 0.935 |
PPIL3 | SNRPG | ENSP00000286175 | ENSP00000272348 | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Cyclophilin peptidylprolyl isomerases | Small nuclear ribonucleoprotein G; Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Appears to function in the U7 snRNP complex that is involved in histone 3’-end processing | 0.959 |
PRPF3 | CCDC84 | ENSP00000315379 | ENSP00000334767 | U4/U6 small nuclear ribonucleoprotein Prp3; Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome; U4/U6 small nucleolar ribonucleoprotein | Coiled-coil domain containing 84 | 0.692 |
PRPF3 | PPIL3 | ENSP00000315379 | ENSP00000286175 | U4/U6 small nuclear ribonucleoprotein Prp3; Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome; U4/U6 small nucleolar ribonucleoprotein | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Cyclophilin peptidylprolyl isomerases | 0.935 |
PRPF3 | SNRPG | ENSP00000315379 | ENSP00000272348 | U4/U6 small nuclear ribonucleoprotein Prp3; Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome; U4/U6 small nucleolar ribonucleoprotein | Small nuclear ribonucleoprotein G; Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Appears to function in the U7 snRNP complex that is involved in histone 3’-end processing | 0.998 |