node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARL15 | FAM9C | ENSP00000433427 | ENSP00000334430 | ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; ARF GTPase family | Protein FAM9C; Family with sequence similarity 9 member C | 0.473 |
ARL15 | SAMD12 | ENSP00000433427 | ENSP00000314173 | ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; ARF GTPase family | Sterile alpha motif domain containing 12 | 0.524 |
ARL15 | UBE2W | ENSP00000433427 | ENSP00000397453 | ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; ARF GTPase family | Ubiquitin-conjugating enzyme E2 W; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Specifically monoubiquitinates the N-terminus of various substrates, including ATXN3, MAPT/TAU, POLR2H/RPB8 and STUB1/CHIP, by recognizing backbone atoms of disordered N-termini. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation [...] | 0.476 |
FAM9C | ARL15 | ENSP00000334430 | ENSP00000433427 | Protein FAM9C; Family with sequence similarity 9 member C | ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; ARF GTPase family | 0.473 |
FAM9C | KIAA1407 | ENSP00000334430 | ENSP00000295878 | Protein FAM9C; Family with sequence similarity 9 member C | Coiled-coil domain-containing protein 191; KIAA1407 | 0.801 |
FAM9C | RPA4 | ENSP00000334430 | ENSP00000362131 | Protein FAM9C; Family with sequence similarity 9 member C | Replication protein A 30 kDa subunit; As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange | 0.475 |
FAM9C | SAMD12 | ENSP00000334430 | ENSP00000314173 | Protein FAM9C; Family with sequence similarity 9 member C | Sterile alpha motif domain containing 12 | 0.539 |
FAM9C | UBE2W | ENSP00000334430 | ENSP00000397453 | Protein FAM9C; Family with sequence similarity 9 member C | Ubiquitin-conjugating enzyme E2 W; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Specifically monoubiquitinates the N-terminus of various substrates, including ATXN3, MAPT/TAU, POLR2H/RPB8 and STUB1/CHIP, by recognizing backbone atoms of disordered N-termini. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation [...] | 0.418 |
KIAA1407 | FAM9C | ENSP00000295878 | ENSP00000334430 | Coiled-coil domain-containing protein 191; KIAA1407 | Protein FAM9C; Family with sequence similarity 9 member C | 0.801 |
RPA4 | FAM9C | ENSP00000362131 | ENSP00000334430 | Replication protein A 30 kDa subunit; As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange | Protein FAM9C; Family with sequence similarity 9 member C | 0.475 |
SAMD12 | ARL15 | ENSP00000314173 | ENSP00000433427 | Sterile alpha motif domain containing 12 | ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; ARF GTPase family | 0.524 |
SAMD12 | FAM9C | ENSP00000314173 | ENSP00000334430 | Sterile alpha motif domain containing 12 | Protein FAM9C; Family with sequence similarity 9 member C | 0.539 |
UBE2W | ARL15 | ENSP00000397453 | ENSP00000433427 | Ubiquitin-conjugating enzyme E2 W; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Specifically monoubiquitinates the N-terminus of various substrates, including ATXN3, MAPT/TAU, POLR2H/RPB8 and STUB1/CHIP, by recognizing backbone atoms of disordered N-termini. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation [...] | ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; ARF GTPase family | 0.476 |
UBE2W | FAM9C | ENSP00000397453 | ENSP00000334430 | Ubiquitin-conjugating enzyme E2 W; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Specifically monoubiquitinates the N-terminus of various substrates, including ATXN3, MAPT/TAU, POLR2H/RPB8 and STUB1/CHIP, by recognizing backbone atoms of disordered N-termini. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation [...] | Protein FAM9C; Family with sequence similarity 9 member C | 0.418 |