| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BCHE | C5orf38 | ENSP00000264381 | ENSP00000334267 | Cholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters; Belongs to the type-B carboxylesterase/lipase family | Protein CEI; Chromosome 5 open reading frame 38 | 0.442 |
| C5orf38 | BCHE | ENSP00000334267 | ENSP00000264381 | Protein CEI; Chromosome 5 open reading frame 38 | Cholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters; Belongs to the type-B carboxylesterase/lipase family | 0.442 |
| C5orf38 | CEL | ENSP00000334267 | ENSP00000361151 | Protein CEI; Chromosome 5 open reading frame 38 | Bile salt-activated lipase; Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides; Belongs to the type-B carboxylesterase/lipase family | 0.440 |
| C5orf38 | FGFR1 | ENSP00000334267 | ENSP00000393312 | Protein CEI; Chromosome 5 open reading frame 38 | Fibroblast growth factor receptor 1; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 lea [...] | 0.427 |
| C5orf38 | GET4 | ENSP00000334267 | ENSP00000265857 | Protein CEI; Chromosome 5 open reading frame 38 | Golgi to ER traffic protein 4 homolog; As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of n [...] | 0.641 |
| C5orf38 | IRX2 | ENSP00000334267 | ENSP00000372056 | Protein CEI; Chromosome 5 open reading frame 38 | Iroquois-class homeodomain protein IRX-2; TALE class homeoboxes and pseudogenes | 0.901 |
| C5orf38 | MTDH | ENSP00000334267 | ENSP00000338235 | Protein CEI; Chromosome 5 open reading frame 38 | Protein LYRIC; Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF- kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance | 0.424 |
| C5orf38 | REN | ENSP00000334267 | ENSP00000272190 | Protein CEI; Chromosome 5 open reading frame 38 | Renin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney | 0.480 |
| C5orf38 | VIPR1 | ENSP00000334267 | ENSP00000327246 | Protein CEI; Chromosome 5 open reading frame 38 | Vasoactive intestinal polypeptide receptor 1; This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The affinity is VIP = PACAP-27 > PACAP-38; Vasoactive intestinal peptide receptor family | 0.472 |
| CEL | C5orf38 | ENSP00000361151 | ENSP00000334267 | Bile salt-activated lipase; Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides; Belongs to the type-B carboxylesterase/lipase family | Protein CEI; Chromosome 5 open reading frame 38 | 0.440 |
| FGFR1 | C5orf38 | ENSP00000393312 | ENSP00000334267 | Fibroblast growth factor receptor 1; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 lea [...] | Protein CEI; Chromosome 5 open reading frame 38 | 0.427 |
| GET4 | C5orf38 | ENSP00000265857 | ENSP00000334267 | Golgi to ER traffic protein 4 homolog; As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of n [...] | Protein CEI; Chromosome 5 open reading frame 38 | 0.641 |
| IRX2 | C5orf38 | ENSP00000372056 | ENSP00000334267 | Iroquois-class homeodomain protein IRX-2; TALE class homeoboxes and pseudogenes | Protein CEI; Chromosome 5 open reading frame 38 | 0.901 |
| MTDH | C5orf38 | ENSP00000338235 | ENSP00000334267 | Protein LYRIC; Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF- kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance | Protein CEI; Chromosome 5 open reading frame 38 | 0.424 |
| REN | C5orf38 | ENSP00000272190 | ENSP00000334267 | Renin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney | Protein CEI; Chromosome 5 open reading frame 38 | 0.480 |
| VIPR1 | C5orf38 | ENSP00000327246 | ENSP00000334267 | Vasoactive intestinal polypeptide receptor 1; This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The affinity is VIP = PACAP-27 > PACAP-38; Vasoactive intestinal peptide receptor family | Protein CEI; Chromosome 5 open reading frame 38 | 0.472 |
