| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| IGFBP1 | PLA2G10 | ENSP00000275525 | ENSP00000393847 | Insulin-like growth factor-binding protein 1; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration | Group 10 secretory phospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine | 0.482 |
| IGFBP1 | SLC13A2 | ENSP00000275525 | ENSP00000392411 | Insulin-like growth factor-binding protein 1; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration | Solute carrier family 13 member 2; Cotransport of sodium ions and dicarboxylates such as succinate and citrate; Solute carriers | 0.652 |
| IGFBP1 | SLC36A2 | ENSP00000275525 | ENSP00000334223 | Insulin-like growth factor-binding protein 1; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration | Proton-coupled amino acid transporter 2; Involved in a pH-dependent electrogenic neuronal transport and sequestration of small amino acids. Transports glycine and proline. Inhibited by sarcosine (By similarity); Belongs to the amino acid/polyamine transporter 2 family | 0.627 |
| IGFBP1 | TNFSF11 | ENSP00000275525 | ENSP00000381775 | Insulin-like growth factor-binding protein 1; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration | Tumor necrosis factor ligand superfamily member 11; Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precu [...] | 0.400 |
| P2RX5 | SLC36A2 | ENSP00000225328 | ENSP00000334223 | P2X purinoceptor 5; Receptor for ATP that acts as a ligand-gated ion channel; Minor histocompatibility antigens | Proton-coupled amino acid transporter 2; Involved in a pH-dependent electrogenic neuronal transport and sequestration of small amino acids. Transports glycine and proline. Inhibited by sarcosine (By similarity); Belongs to the amino acid/polyamine transporter 2 family | 0.586 |
| PLA2G10 | IGFBP1 | ENSP00000393847 | ENSP00000275525 | Group 10 secretory phospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine | Insulin-like growth factor-binding protein 1; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration | 0.482 |
| PLA2G10 | SLC13A2 | ENSP00000393847 | ENSP00000392411 | Group 10 secretory phospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine | Solute carrier family 13 member 2; Cotransport of sodium ions and dicarboxylates such as succinate and citrate; Solute carriers | 0.641 |
| PLA2G10 | SLC36A2 | ENSP00000393847 | ENSP00000334223 | Group 10 secretory phospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine | Proton-coupled amino acid transporter 2; Involved in a pH-dependent electrogenic neuronal transport and sequestration of small amino acids. Transports glycine and proline. Inhibited by sarcosine (By similarity); Belongs to the amino acid/polyamine transporter 2 family | 0.642 |
| PLA2G10 | TNFSF11 | ENSP00000393847 | ENSP00000381775 | Group 10 secretory phospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine | Tumor necrosis factor ligand superfamily member 11; Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precu [...] | 0.534 |
| SLC13A2 | IGFBP1 | ENSP00000392411 | ENSP00000275525 | Solute carrier family 13 member 2; Cotransport of sodium ions and dicarboxylates such as succinate and citrate; Solute carriers | Insulin-like growth factor-binding protein 1; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration | 0.652 |
| SLC13A2 | PLA2G10 | ENSP00000392411 | ENSP00000393847 | Solute carrier family 13 member 2; Cotransport of sodium ions and dicarboxylates such as succinate and citrate; Solute carriers | Group 10 secretory phospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine | 0.641 |
| SLC13A2 | SLC36A2 | ENSP00000392411 | ENSP00000334223 | Solute carrier family 13 member 2; Cotransport of sodium ions and dicarboxylates such as succinate and citrate; Solute carriers | Proton-coupled amino acid transporter 2; Involved in a pH-dependent electrogenic neuronal transport and sequestration of small amino acids. Transports glycine and proline. Inhibited by sarcosine (By similarity); Belongs to the amino acid/polyamine transporter 2 family | 0.726 |
| SLC13A2 | TNFSF11 | ENSP00000392411 | ENSP00000381775 | Solute carrier family 13 member 2; Cotransport of sodium ions and dicarboxylates such as succinate and citrate; Solute carriers | Tumor necrosis factor ligand superfamily member 11; Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precu [...] | 0.600 |
| SLC1A7 | SLC36A2 | ENSP00000478639 | ENSP00000334223 | Amino acid transporter; Solute carrier family 1 member 7 | Proton-coupled amino acid transporter 2; Involved in a pH-dependent electrogenic neuronal transport and sequestration of small amino acids. Transports glycine and proline. Inhibited by sarcosine (By similarity); Belongs to the amino acid/polyamine transporter 2 family | 0.829 |
| SLC1A7 | SLC6A16 | ENSP00000478639 | ENSP00000338627 | Amino acid transporter; Solute carrier family 1 member 7 | Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5; Solute carrier family 6 member 16 | 0.552 |
| SLC1A7 | SLC6A18 | ENSP00000478639 | ENSP00000323549 | Amino acid transporter; Solute carrier family 1 member 7 | Sodium-dependent neutral amino acid transporter B(0)AT3; Functions as a sodium and chloride-dependent neutral amino acid transporter; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A18 subfamily | 0.810 |
| SLC1A7 | SLC6A19 | ENSP00000478639 | ENSP00000305302 | Amino acid transporter; Solute carrier family 1 member 7 | Sodium-dependent neutral amino acid transporter B(0)AT1; Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells. This uptake is sodium-dependent and chloride- independent; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A19 subfamily | 0.817 |
| SLC1A7 | SLC6A20 | ENSP00000478639 | ENSP00000346298 | Amino acid transporter; Solute carrier family 1 member 7 | Sodium- and chloride-dependent transporter XTRP3; Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N- methylated amino acids. Involved in the transport of glycine; Solute carriers | 0.812 |
| SLC36A2 | IGFBP1 | ENSP00000334223 | ENSP00000275525 | Proton-coupled amino acid transporter 2; Involved in a pH-dependent electrogenic neuronal transport and sequestration of small amino acids. Transports glycine and proline. Inhibited by sarcosine (By similarity); Belongs to the amino acid/polyamine transporter 2 family | Insulin-like growth factor-binding protein 1; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration | 0.627 |
| SLC36A2 | P2RX5 | ENSP00000334223 | ENSP00000225328 | Proton-coupled amino acid transporter 2; Involved in a pH-dependent electrogenic neuronal transport and sequestration of small amino acids. Transports glycine and proline. Inhibited by sarcosine (By similarity); Belongs to the amino acid/polyamine transporter 2 family | P2X purinoceptor 5; Receptor for ATP that acts as a ligand-gated ion channel; Minor histocompatibility antigens | 0.586 |
