node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BTLA | CD160 | ENSP00000333919 | ENSP00000235933 | B- and T-lymphocyte attenuator; Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response; CD molecules | CD160 antigen; Receptor showing broad specificity for both classical and non-classical MHC class I molecules | 0.796 |
BTLA | CD274 | ENSP00000333919 | ENSP00000370989 | B- and T-lymphocyte attenuator; Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response; CD molecules | Programmed cell death 1 ligand 1; Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production; Belongs to the immunoglobulin superfamily. BTN/MOG family | 0.710 |
BTLA | CTLA4 | ENSP00000333919 | ENSP00000303939 | B- and T-lymphocyte attenuator; Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response; CD molecules | Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28 | 0.752 |
BTLA | HAVCR2 | ENSP00000333919 | ENSP00000312002 | B- and T-lymphocyte attenuator; Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response; CD molecules | Hepatitis A virus cellular receptor 2; Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF- kappaB and NFAT promoter activities resulting in the los [...] | 0.750 |
BTLA | LAG3 | ENSP00000333919 | ENSP00000203629 | B- and T-lymphocyte attenuator; Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response; CD molecules | Lymphocyte activation gene 3 protein; Involved in lymphocyte activation. Binds to HLA class-II antigens; CD molecules | 0.764 |
BTLA | PTPN11 | ENSP00000333919 | ENSP00000340944 | B- and T-lymphocyte attenuator; Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response; CD molecules | Tyrosine-protein phosphatase non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at ’Tyr-722’ resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73; Protein tyrosine phosphatases, non-receptor type | 0.969 |
BTLA | PTPN6 | ENSP00000333919 | ENSP00000391592 | B- and T-lymphocyte attenuator; Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response; CD molecules | Tyrosine-protein phosphatase non-receptor type 6; Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis; Protein tyrosine phosphatases, non-receptor type | 0.945 |
BTLA | TNFRSF14 | ENSP00000333919 | ENSP00000347948 | B- and T-lymphocyte attenuator; Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response; CD molecules | Tumor necrosis factor receptor superfamily member 14; Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells; CD molecules | 0.999 |
BTLA | TNFSF14 | ENSP00000333919 | ENSP00000469049 | B- and T-lymphocyte attenuator; Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response; CD molecules | Tumor necrosis factor ligand superfamily member 14; Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus; CD molecules | 0.721 |
BTLA | VTCN1 | ENSP00000333919 | ENSP00000358470 | B- and T-lymphocyte attenuator; Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response; CD molecules | V-set domain-containing T-cell activation inhibitor 1; Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor- associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation; Immunoglobulin like domain containing | 0.961 |
CD160 | BTLA | ENSP00000235933 | ENSP00000333919 | CD160 antigen; Receptor showing broad specificity for both classical and non-classical MHC class I molecules | B- and T-lymphocyte attenuator; Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response; CD molecules | 0.796 |
CD160 | CD274 | ENSP00000235933 | ENSP00000370989 | CD160 antigen; Receptor showing broad specificity for both classical and non-classical MHC class I molecules | Programmed cell death 1 ligand 1; Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production; Belongs to the immunoglobulin superfamily. BTN/MOG family | 0.598 |
CD160 | CTLA4 | ENSP00000235933 | ENSP00000303939 | CD160 antigen; Receptor showing broad specificity for both classical and non-classical MHC class I molecules | Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28 | 0.675 |
CD160 | HAVCR2 | ENSP00000235933 | ENSP00000312002 | CD160 antigen; Receptor showing broad specificity for both classical and non-classical MHC class I molecules | Hepatitis A virus cellular receptor 2; Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF- kappaB and NFAT promoter activities resulting in the los [...] | 0.766 |
CD160 | LAG3 | ENSP00000235933 | ENSP00000203629 | CD160 antigen; Receptor showing broad specificity for both classical and non-classical MHC class I molecules | Lymphocyte activation gene 3 protein; Involved in lymphocyte activation. Binds to HLA class-II antigens; CD molecules | 0.803 |
CD160 | PTPN11 | ENSP00000235933 | ENSP00000340944 | CD160 antigen; Receptor showing broad specificity for both classical and non-classical MHC class I molecules | Tyrosine-protein phosphatase non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at ’Tyr-722’ resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73; Protein tyrosine phosphatases, non-receptor type | 0.402 |
CD160 | TNFRSF14 | ENSP00000235933 | ENSP00000347948 | CD160 antigen; Receptor showing broad specificity for both classical and non-classical MHC class I molecules | Tumor necrosis factor receptor superfamily member 14; Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells; CD molecules | 0.892 |
CD160 | TNFSF14 | ENSP00000235933 | ENSP00000469049 | CD160 antigen; Receptor showing broad specificity for both classical and non-classical MHC class I molecules | Tumor necrosis factor ligand superfamily member 14; Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus; CD molecules | 0.602 |
CD274 | BTLA | ENSP00000370989 | ENSP00000333919 | Programmed cell death 1 ligand 1; Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production; Belongs to the immunoglobulin superfamily. BTN/MOG family | B- and T-lymphocyte attenuator; Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response; CD molecules | 0.710 |
CD274 | CD160 | ENSP00000370989 | ENSP00000235933 | Programmed cell death 1 ligand 1; Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production; Belongs to the immunoglobulin superfamily. BTN/MOG family | CD160 antigen; Receptor showing broad specificity for both classical and non-classical MHC class I molecules | 0.598 |