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  • 11.0 [archived version]
STRINGSTRING
WTIP WTIP SCGB2B2 SCGB2B2 TRIM28 TRIM28 UBA2 UBA2 ZNF599 ZNF599 LSM14A LSM14A EFCAB13 EFCAB13 PAPLN PAPLN
"ZNF599" - Zinc finger protein 599 in Homo sapiens
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ZNF599Zinc finger protein 599; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family (588 aa)    
Predicted Functional Partners:
TRIM28
Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] (835 aa)
     
    0.903
EFCAB13
EF-hand calcium-binding domain-containing protein 13; EF-hand calcium binding domain 13 (973 aa)
       
 
  0.555
SCGB2B2
Secretoglobin family 2B member 2; Secretoglobins (96 aa)
           
  0.555
LSM14A
Protein LSM14 homolog A; Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs; LSm proteins (463 aa)
     
   
  0.515
UBA2
SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2; Ubiquitin like modifier activating enzymes (640 aa)
       
 
  0.491
WTIP
Wilms tumor protein 1-interacting protein; Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadheri [...] (430 aa)
       
 
  0.457
PAPLN
Papilin, proteoglycan like sulfated glycoprotein; Belongs to the papilin family (1251 aa)
           
  0.400
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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